This study was supported by the Key Research and Development Program of the Ministry of Science and Technology (2022YFF1202901; 2023YFC3403400), the National Natural Science Foundation of China (82171404), the Natural Science Foundation of Guangdong Province of China (2023A1515011529), the Science and Technology Planning Project of Guangzhou City (2023A03J0181, 2024A04J6481), the Fundamental Research Funds for the Central Universities (22yklj04), Shanghai Frontiers Science Center for Biomacromolucules and Precision Medicine, the Double First-Class Initiative Fund of ShanghaiTech University, Shanghai Local College Capacity Building Project (22010202700) and the Research Start-up Founds of Sun Yat-sen University (Funded Talent[2020]18).