De Hert M, Correll CU, Bobes J, Cetkovich-Bakmas M, Cohen DAN, Asai I, et al. Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care. World Psychiatry. 2011;10:52–77.

Article  PubMed  Google Scholar 

Simon J, Wienand D, Park AL, Wippel C, Mayer S, Heilig D, et al. Excess resource use and costs of physical comorbidities in individuals with mental health disorders: A systematic literature review and meta-analysis. Eur Neuropsychopharmacol. 2023;66:14–27.

Article  CAS  PubMed  Google Scholar 

Vieta E. Staging and psychosocial early intervention in bipolar disorder. Lancet Psychiatry. 2015;2:483–5.

Article  PubMed  Google Scholar 

Liu NH, Daumit GL, Dua T, Aquila R, Charlson F, Cuijpers P, et al. Excess mortality in persons with severe mental disorders: a multilevel intervention framework and priorities for clinical practice, policy and research agendas. World Psychiatry. 2017;16:30–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hayes JF, Miles J, Walters K, King M, Osborn DP. A systematic review and meta-analysis of premature mortality in bipolar affective disorder. Acta Psychiatr Scand. 2015;131:417–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chan JKN, Tong CHY, Wong CSM, Chen EYH, Chang WC. Life expectancy and years of potential life lost in bipolar disorder: systematic review and meta-analysis. Br J Psychiatry. 2022;221:567–76.

Article  PubMed  Google Scholar 

Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6:e1000097.

Article  PubMed  PubMed Central  Google Scholar 

Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA. 2000;283:2008–12.

Article  CAS  PubMed  Google Scholar 

American Psychiatric Association (APA). Diagnostic and Statistical Manual of Mental Disorders – DSM-IVTR. 4th edition. American Psychiatric Association; Washington DC, 2000.

World Health Organization (WHO). The ICD-10 Classification of Mental and Behavioural Disorders – Diagnostic Criteria for Research. World Health Association. Genève, 1993.

Agustí A, Celli BR, Criner GJ, Halpin D, Anzueto A, Barnes P, et al. Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary. Eur Respir J. 2023;61:2300239.

Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Available at: https://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.

Herzog R, Álvarez-Pasquin MJ, Díaz C, Del Barrio JL, Estrada JM, Gil Á. Are healthcare workers’ intentions to vaccinate related to their knowledge, beliefs and attitudes? A systematic review. BMC Public Health. 2013;13:154.

Article  PubMed  PubMed Central  Google Scholar 

Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60.

Article  PubMed  PubMed Central  Google Scholar 

Higgins JP, Thompson SG. Controlling the risk of spurious findings from meta-regression. Stat Med. 2004;23:1663–82.

Article  PubMed  Google Scholar 

R Core Team. R: a language and environment for statistical computing. Published online 2021. Accessed December 26, 2023. https://www.R-project.org/.

Viechtbauer W. Conducting meta-analyses in R with the metafor package. J Stat Softw. 2010;36:1–48.

Balduzzi S, Rücker G, Schwarzer G. How to perform a meta-analysis with R: a practical tutorial. Evid Based Ment Health. 2019;22:153–60.

Article  PubMed  PubMed Central  Google Scholar 

Harrer M, Cuijpers P, Furukawa TA, Ebert DD Doing Meta-Analysis With R: A Hands-On Guide. 1st ed. Chapman & Hall/CRC Press; 2021.

Barcella CA, Polcwiartek C, Mohr GH, Hodges G, Søndergaard K, Niels Bang C, et al. Severe mental illness is associated with increased mortality and severe course of COVID-19. Acta Psychiatr Scand. 2021;144:82–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bendayan R, Kraljevic Z, Shaari S, Das-Munshi J, Leipold L, Chaturvedi J, et al. Mapping multimorbidity in individuals with schizophrenia and bipolar disorders: evidence from the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLAM BRC) case register. BMJ Open. 2022;12:e054414.

Article  PubMed  PubMed Central  Google Scholar 

Carney CP, Jones LE. Medical comorbidity in women and men with bipolar disorders: a population-based controlled study. Psychosom Med. 2006;68:684–91.

Article  PubMed  Google Scholar 

Chen PH, Tsai SY, Pan CH, Chen YL, Su SS, Chen CC, et al. Prevalence and 5-year trend of incidence for medical illnesses after the diagnosis of bipolar disorder: A nationwide cohort study. Aust N Z J Psychiatry. 2022;56:1164–76.

Article  PubMed  Google Scholar 

Hossain S, Mainali P, Bhimanadham NN, Imran S, Ahmad N, Patel RS. Medical and psychiatric comorbidities in bipolar disorder: insights from national inpatient population-based study. Cureus. 2019;11:e5636.

PubMed  PubMed Central  Google Scholar 

Kilbourne AM, Cornelius JR, Han X, Pincus HA, Shad M, Salloum I, et al. Burden of general medical conditions among individuals with bipolar disorder. Bipolar Disord. 2004;6:368–73.

Article  PubMed  Google Scholar 

Patel RS, Virani S, Saeed H, Nimmagadda S, Talukdar J, Youssef NA. Gender differences and comorbidities in U.S. adults with bipolar disorder. Brain Sci. 2018;8:168.

Article  PubMed  PubMed Central  Google Scholar 

Perugi G, Quaranta G, Belletti S, Casalini F, Mosti N, Toni C, et al. General medical conditions in 347 bipolar disorder patients: clinical correlates of metabolic and autoimmune-allergic diseases. J Affect Disord. 2015;170:95–103.

Article  PubMed  Google Scholar 

Schoepf D, Heun R. Bipolar disorder and comorbidity: increased prevalence and increased relevance of comorbidity for hospital-based mortality during a 12.5-year observation period in general hospital admissions. J Affect Disord. 2014;169:170–8.

Article  PubMed  Google Scholar 

Yang SY, Liao YT, Liu HC, Chen WJ, Chen CC, Kuo CJ. Antipsychotic drugs, mood stabilizers, and risk of pneumonia in bipolar disorder: a nationwide case-control study. J Clin Psychiatry. 2013;74:e79–86.

Article  CAS  PubMed  Google Scholar 

Smith DJ, Martin D, McLean G, Langan J, Guthrie B, Mercer SW. Multimorbidity in bipolar disorder and undertreatment of cardiovascular disease: a cross sectional study. BMC Med. 2013;11:263.

Article  PubMed  PubMed Central  Google Scholar 

Munoli RN, Praharaj SK, Sharma PS. Co-morbidity in bipolar disorder: a retrospective study. Indian J Psychol Med. 2014;36:270–5.

Article  PubMed  PubMed Central  Google Scholar 

Attar R, Valentin JB, Andell P, Nielsen RE, Jensen SE. Major adverse cardiovascular events following acute coronary syndrome in patients with bipolar disorder. Int J Cardiol. 2022;363:1–5.

Article  PubMed  Google Scholar 

Bodén R, Molin E, Jernberg T, Kieler H, Lindahl B, Sundström J. Higher mortality after myocardial infarction in patients with severe mental illness: a nationwide cohort study. J Intern Med. 2015;277:727–36.

Article  PubMed  Google Scholar 

Fleetwood K, Wild SH, Smith DJ, Mercer SW, Licence K, Sudlow CLM, et al. Severe mental illness and mortality and coronary revascularisation following a myocardial infarction: a retrospective cohort study. BMC Med. 2021;19:67.

Article  PubMed  PubMed Central  Google Scholar 

Heiberg IH, Jacobsen BK, Balteskard L, Bramness JG, Naess Ø, Ystrom E, et al. Undiagnosed cardiovascular disease prior to cardiovascular death in individuals with severe mental illness. Acta Psychiatr Scand. 2019;139:558–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heiberg IH, Nesvåg R, Balteskard L, Bramness JG, Hultman CM, Naess Ø, et al. Diagnostic tests and treatment procedures performed prior to cardiovascular death in individuals with severe mental illness. Acta Psychiatr Scand. 2020;141:439–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hsu JH, Chien IC, Lin CH. Increased risk of chronic obstructive pulmonary disease in patients with bipolar disorder: a population-based study. J Affect Disord. 2017;220:43–48.

Article  PubMed