Peripartum allopregnanolone blood concentrations and depressive symptoms: a systematic review and individual participant data meta-analysis

Trost S, Beauregard J, Chandra G, Njie F, Berry J, Harvey A, et al. Pregnancy-Related Deaths: Data from Maternal Mortality Review Committees in 36 US States, 2017–2019 Atlanta, GA: Centers for Disease Control and Prevention UDoHaHS; 2022. Available from: https://www.cdc.gov/reproductivehealth/maternal-mortality/erase-mm/data-mmrc.html.

Knight M, Bunch K, Tuffnell D, Patel R, Shakespeare J, Kotnis R, et al. Saving Lives, Improving Mothers’ Care - Lessons learned to inform maternity care from the UK and Ireland Confidential Enquiries into Maternal Deaths and Morbidity 2017-19 Oxford, UK: National Perinatal Epidemiology Unit, University of Oxford; 2021. https://www.npeu.ox.ac.uk/assets/downloads/mbrrace-uk/reports/maternal-report-2021/MBRRACE-UK_Maternal_Report_2021_-_FINAL_-_WEB_VERSION.pdf.

Liu X, Wang S, Wang G. Prevalence and Risk Factors of Postpartum Depression in Women: A Systematic Review and Meta-analysis. J Clin Nurs. 2022;31:2665–77.

Article  PubMed  Google Scholar 

Yonkers KA, Vigod S, Ross LE. Diagnosis, pathophysiology, and management of mood disorders in pregnant and postpartum women. Obstet Gynecol. 2011;117:961–77.

Article  PubMed  Google Scholar 

Field T. Postpartum depression effects on early interactions, parenting, and safety practices: a review. Infant Behav Dev. 2010;33:1–6.

Article  PubMed  Google Scholar 

Perry DF, Ettinger AK, Mendelson T, Le HN. Prenatal depression predicts postpartum maternal attachment in low-income Latina mothers with infants. Infant Behav Dev. 2011;34:339–50.

Article  PubMed  Google Scholar 

Dennis CL, McQueen K. The relationship between infant-feeding outcomes and postpartum depression: a qualitative systematic review. Pediatrics. 2009;123:e736–51.

Article  PubMed  Google Scholar 

Tuovinen S, Lahti-Pulkkinen M, Girchenko P, Lipsanen J, Lahti J, Heinonen K, et al. Maternal depressive symptoms during and after pregnancy and child developmental milestones. Depress Anxiety. 2018;35:732–41.

Article  PubMed  Google Scholar 

Leis JA, Heron J, Stuart EA, Mendelson T. Associations between maternal mental health and child emotional and behavioral problems: does prenatal mental health matter? J Abnorm Child Psychol. 2014;42:161–71.

Article  PubMed  Google Scholar 

Pearson RM, Evans J, Kounali D, Lewis G, Heron J, Ramchandani PG, et al. Maternal depression during pregnancy and the postnatal period: risks and possible mechanisms for offspring depression at age 18 years. JAMA Psychiatry. 2013;70:1312–9.

Article  PubMed  PubMed Central  Google Scholar 

Schweizer-Schubert S, Gordon JL, Eisenlohr-Moul TA, Meltzer-Brody S, Schmalenberger KM, Slopien R, et al. Steroid Hormone Sensitivity in Reproductive Mood Disorders: On the Role of the GABA(A) Receptor Complex and Stress During Hormonal Transitions. Front Med. 2020;7:479646.

Article  Google Scholar 

Antonoudiou P, Colmers PLW, Walton NL, Weiss GL, Smith AC, Nguyen DP, et al. Allopregnanolone Mediates Affective Switching Through Modulation of Oscillatory States in the Basolateral Amygdala. Biol Psychiatry. 2022;91:283–93.

Article  CAS  PubMed  Google Scholar 

Callachan H, Cottrell GA, Hather NY, Lambert JJ, Nooney JM, Peters JA. Modulation of the GABAA receptor by progesterone metabolites. Proc R Soc Lond B Biol Sci. 1987;231:359–69.

Article  CAS  PubMed  Google Scholar 

Avoli M, Krnjevic K. The Long and Winding Road to Gamma-Amino-Butyric Acid as Neurotransmitter. Can J Neurol Sci. 2016;43:219–26.

Article  PubMed  Google Scholar 

Parakala ML, Zhang Y, Modgil A, Chadchankar J, Vien TN, Ackley MA, et al. Metabotropic, but not allosteric, effects of neurosteroids on GABAergic inhibition depend on the phosphorylation of GABA(A) receptors. J Biol Chem. 2019;294:12220–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Semyanov A, Walker MC, Kullmann DM. GABA uptake regulates cortical excitability via cell type-specific tonic inhibition. Nat Neurosci. 2003;6:484–90.

Article  CAS  PubMed  Google Scholar 

Stell BM, Brickley SG, Tang CY, Farrant M, Mody I. Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors. Proc Natl Acad Sci USA. 2003;100:14439–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Crowley SK, Girdler SS. Neurosteroid, GABAergic and hypothalamic pituitary adrenal (HPA) axis regulation: what is the current state of knowledge in humans? Psychopharmacology. 2014;231:3619–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sarkar J, Wakefield S, MacKenzie G, Moss SJ, Maguire J. Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors. J Neurosci. 2011;31:18198–210.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Walton NL, Antonoudiou P, Maguire JL. Neurosteroid influence on affective tone. Neurosci Biobehav Rev. 2023;152:105327.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pisu MG, Concas L, Siddi C, Serra M, Porcu P. The Allopregnanolone Response to Acute Stress in Females: Preclinical and Clinical Studies. Biomolecules. 2022;12:1262.

Cook JB, Dumitru AM, O’Buckley TK, Morrow AL. Ethanol administration produces divergent changes in GABAergic neuroactive steroid immunohistochemistry in the rat brain. Alcohol Clin Exp Res. 2014;38:90–9.

Article  CAS  PubMed  Google Scholar 

Kanes S, Colquhoun H, Gunduz-Bruce H, Raines S, Arnold R, Schacterle A, et al. Brexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial. Lancet. 2017;390:480–9.

Article  CAS  PubMed  Google Scholar 

Meltzer-Brody S, Colquhoun H, Riesenberg R, Epperson CN, Deligiannidis KM, Rubinow DR, et al. Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials. Lancet. 2018;392:1058–70.

Article  CAS  PubMed  Google Scholar 

Deligiannidis KM, Citrome L, Huang MY, Acaster S, Fridman M, Bonthapally V, et al. Effect of Zuranolone on Concurrent Anxiety and Insomnia Symptoms in Women With Postpartum Depression. J Clin Psychiatry. 2023;84:22m14475.

Epperson CN, Rubinow DR, Meltzer-Brody S, Deligiannidis KM, Riesenberg R, Krystal AD, et al. Effect of brexanolone on depressive symptoms, anxiety, and insomnia in women with postpartum depression: Pooled analyses from 3 double-blind, randomized, placebo-controlled clinical trials in the HUMMINGBIRD clinical program. J Affect Disord. 2023;320:353–9.

Article  CAS  PubMed  Google Scholar 

Deligiannidis KM, Meltzer-Brody S, Gunduz-Bruce H, Doherty J, Jonas J, Li S, et al. Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial. JAMA Psychiatry. 2021;78:951–9.

Article  PubMed  Google Scholar 

Deligiannidis KM, Meltzer-Brody S, Maximos B, Peeper EQ, Freeman M, Lasser R, et al. Zuranolone for the Treatment of Postpartum Depression. Am J Psychiatry. 2023;180:668–75.

Article  PubMed  Google Scholar 

Osborne LM, Betz JF, Yenokyan G, Standeven LR, Payne JL. The Role of Allopregnanolone in Pregnancy in Predicting Postpartum Anxiety Symptoms. Front Psychol. 2019;10:1033.

Article  PubMed  PubMed Central  Google Scholar 

Nappi RE, Petraglia F, Luisi S, Polatti F, Farina C, Genazzani AR. Serum allopregnanolone in women with postpartum “blues”. Obstet Gynecol. 2001;97:77–80.

CAS  PubMed  Google Scholar 

Hellgren C, Akerud H, Skalkidou A, Backstrom T, Sundstrom-Poromaa I. Low serum allopregnanolone is associated with symptoms of depression in late pregnancy. Neuropsychobiology. 2014;69:147–53.

Article  CAS  PubMed  Google Scholar 

Epperson CN, Gueorguieva R, Czarkowski KA, Stiklus S, Sellers E, Krystal JH, et al. Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study. Psychopharmacology. 2006;186:425–33.

Article  CAS  PubMed  Google Scholar 

Deligiannidis KM, Sikoglu EM, Shaffer SA, Frederick B, Svenson AE, Kopoyan A, et al. GABAergic neuroactive steroids and resting-state functional connectivity in postpartum depression: a preliminary study. J Psychiatr Res. 2013;47:816–28.

Article  PubMed  PubMed Central  Google Scholar 

Maguire J, Mody I. GABA(A)R plasticity during pregnancy: relevance to postpartum depression. Neuron. 2008;59:207–13.

Article  CAS  PubMed  PubMed Central 

留言 (0)

沒有登入
gif