Transcriptome signatures of the medial prefrontal cortex underlying GABAergic control of resilience to chronic stress exposure

Morris HM, Hashimoto T, Lewis DA. Alterations in somatostatin mRNA expression in the dorsolateral prefrontal cortex of subjects with schizophrenia or schizoaffective disorder. Cereb Cortex. 2008;18:1575–87.

Article  PubMed  Google Scholar 

Sibille E, Morris HM, Kota RS, Lewis DA. GABA-related transcripts in the dorsolateral prefrontal cortex in mood disorders. Int J Neuropsychopharmacol. 2011;14:721–34.

Article  PubMed  CAS  Google Scholar 

Tripp A, Kota RS, Lewis DA, Sibille E. Reduced somatostatin in subgenual anterior cingulate cortex in major depression. Neurobiol Dis. 2011;42:116–24.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fee C, Banasr M, Sibille E. Somatostatin-positive gamma-aminobutyric acid interneuron deficits in depression: cortical microcircuit and therapeutic perspectives. Biol Psychiatry. 2017;82:549–59.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Davies P, Katzman R, Terry RD. Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa. Nature. 1980;288:279–80.

Article  PubMed  CAS  Google Scholar 

Chen Y, Hunter E, Arbabi K, Guet-McCreight A, Consens M, Felsky D, et al. Robust differences in cortical cell type proportions across healthy human aging inferred through cross-dataset transcriptome analyses. Neurobiol Aging. 2023;125:49–61.

Article  PubMed  CAS  Google Scholar 

Mathys H, Peng Z, Boix CA, Victor MB, Leary N, Babu S, et al. Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer’s disease pathology. Cell. 2023;186:4365–4385 e4327.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jefferson SJ, Feng M, Chon U, Guo Y, Kim Y, Luscher B. Disinhibition of somatostatin interneurons confers resilience to stress in male but not female mice. Neurobiol Stress. 2020;13:100238.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lin LC, Sibille E. Somatostatin, neuronal vulnerability and behavioral emotionality. Mol Psychiatry. 2015;20:377–87.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lyu J, Nagarajan R, Kambali M, Wang M, Rudolph U. Selective inhibition of somatostatin-positive dentate hilar interneurons induces age-related cellular changes and cognitive dysfunction. PNAS Nexus. 2023;2:pgad134.

Article  PubMed  PubMed Central  Google Scholar 

Luscher B, Maguire JL, Rudolph U, Sibille E. GABA(A) receptors as targets for treating affective and cognitive symptoms of depression. Trends Pharmacol Sci. 2023;44:586–600.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Schmid LC, Mittag M, Poll S, Steffen J, Wagner J, Geis HR, et al. Dysfunction of somatostatin-positive interneurons associated with memory deficits in an Alzheimer’s disease model. Neuron. 2016;92:114–25.

Article  PubMed  CAS  Google Scholar 

Rudy B, Fishell G, Lee S, Hjerling-Leffler J. Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons. Dev Neurobiol. 2011;71:45–61.

Article  PubMed  PubMed Central  Google Scholar 

Chiu CQ, Lur G, Morse TM, Carnevale NT, Ellis-Davies GC, Higley MJ. Compartmentalization of GABAergic inhibition by dendritic spines. Science. 2013;340:759–62.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yao Z, van Velthoven CTJ, Nguyen TN, Goldy J, Sedeno-Cortes AE, Baftizadeh F, et al. A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation. Cell. 2021;184:3222–3241 e3226.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Booker SA, Vida I. Morphological diversity and connectivity of hippocampal interneurons. Cell and tissue research. 2018;373:619–41.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Joffe ME, Maksymetz J, Luschinger JR, Dogra S, Ferranti AS, Luessen DJ, et al. Acute restraint stress redirects prefrontal cortex circuit function through mGlu(5) receptor plasticity on somatostatin-expressing interneurons. Neuron. 2022;110:1068–1083 e1065.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chiu CQ, Martenson JS, Yamazaki M, Natsume R, Sakimura K, Tomita S, et al. Input-specific NMDAR-dependent potentiation of dendritic GABAergic inhibition. Neuron. 2018;97:368–377 e363.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fuchs T, Jefferson SJ, Hooper A, Yee PH, Maguire J, Luscher B. Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state. Mol Psychiatry. 2017;22:920–30.

Article  PubMed  CAS  Google Scholar 

LaPlant Q, Chakravarty S, Vialou V, Mukherjee S, Koo JW, Kalahasti G, et al. Role of nuclear factor kappaB in ovarian hormone-mediated stress hypersensitivity in female mice. Biol Psychiatry. 2009;65:874–80.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Labonte B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, et al. Sex-specific transcriptional signatures in human depression. Nat Med. 2017;23:1102–11.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ, et al. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell. 2007;131:391–404.

Article  PubMed  CAS  Google Scholar 

Nestler EJ, Russo SJ. Neurobiological basis of stress resilience. Neuron. 2024;112:1911–29.

Article  PubMed  CAS  Google Scholar 

Jiang T, Feng M, Hutson A, Guo Y, Luscher B. Sex-specific GABAergic microcircuits that switch vulnerability into resilience to stress and reverse the effects of chronic stress exposure. Mol Psychiatry. https://doi.org/10.1038/s41380-024-02835-8.

Schweizer C, Balsiger S, Bluethmann H, Mansuy IM, Fritschy JM, Mohler H, et al. The gamma 2 subunit of GABA(A) receptors is required for maintenance of receptors at mature synapses. Mol Cell Neurosci. 2003;24:442–50.

Article  PubMed  CAS  Google Scholar 

Whitten WK. Occurence of anoestrus in mice caged in groups. J Endocrinol. 1959;18:102–7.

Article  PubMed  CAS  Google Scholar 

Shen Q, Lal R, Luellen BA, Earnheart JC, Andrews AM, Luscher B. Gamma-aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression. Biol Psychiatry. 2010;68:512–20.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Isingrini E, Camus V, Le Guisquet AM, Pingaud M, Devers S, Belzung C. Association between repeated unpredictable chronic mild stress (UCMS) procedures with a high fat diet: a model of fluoxetine resistance in mice. PLoS ONE. 2010;5:e10404.

Article  PubMed  PubMed Central  Google Scholar 

Feng M, Crowley NA, Patel A, Guo Y, Bugni SE, Luscher B. Reversal of a treatment-resistant, depression-related brain state with the Kv7 Channel Opener Retigabine. Neuroscience. 2019;406:109–25.

Article  PubMed  CAS  Google Scholar 

Chen S. Ultrafast one‐pass FASTQ data preprocessing, quality control, and deduplication using fastp. iM

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