Dhadde SB, Durg S, Potadar PP (2014) Piroxicam attenuates 3-nitropropionic acid-induced brain oxidative stress and behavioral alteration in mice. Toxicol Mech Methods 24(9):672–678

Article  PubMed  Google Scholar 

Sandhir R, Yadav A, Mehrotra A, Sunkaria A, Singh A, Sharma S (2014) Curcumin nanoparticles attenuate neurochemical and neurobehavioral deficits in experimental model of Huntington’s disease. NeuroMol Med 16(1):106–118

Article  CAS  Google Scholar 

Bhatt R, Singh D, Prakash A, Mishra N (2015) Development, characterization and nasal delivery of rosmarinic acid-loaded solid lipid nanoparticles for the effective management of Huntington’s disease. Drug Deliv 22(7):931–939

Article  CAS  PubMed  Google Scholar 

Veldman MB, Rios-Galdamez Y, Lu XH, Gu X, Qin W, Li S, Yang XW, Lin S (2015) The N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington’s disease model. Mol Neurodegener 10(1):1–6

Article  Google Scholar 

Kumar P, Kalonia H, Kumar A (2010) Huntington’s disease: pathogenesis to animal models. Pharmacol Rep 62(1):1–4

Article  CAS  PubMed  Google Scholar 

Frank S (2010) Tetrabenazine: the first approved drug for the treatment of chorea in US patients with Huntington disease. Neuropsychiatr Dis Treat 6:657

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bjørklund G, Dadar M, Martins N, Chirumbolo S, Goh BH, Smetanina K, Lysiuk R (2018) Brief challenges on medicinal plants: an eye-opening look at ageing-related disorders. Basic Clin Pharmacol Toxicol 122(6):539–558

Article  PubMed  Google Scholar 

Panzarini E, Mariano S, Tacconi S, Carata E, Tata AM, Dini L (2020) Novel therapeutic delivery of nanocurcumin in central nervous system related disorders. Nanomaterials 11(1):2

Article  PubMed  PubMed Central  Google Scholar 

Cárdenas-Rodríguez N, Bandala C, Vanoye-Carlo A, Ignacio-Mejia I, Gómez-Manzo S, Hernandez-Cruz EY, Pedraza-Chaverri J, Carmona-Aparicio L, Hernandez-Ochoa B (2021) Use of antioxidants for the neuro-therapeutic management of COVID-19. Antioxidants 10(6):971

Article  PubMed  PubMed Central  Google Scholar 

Etman SM, Elnaggar YS, Abdelmonsif DA, Abdallah OY (2018) Oral brain-targeted microemulsion for enhanced piperine delivery in Alzheimer’s disease therapy: in vitro appraisal, in vivo activity, and nanotoxicity. AAPS PharmSciTech 19(8):3698–3711

Article  CAS  PubMed  Google Scholar 

Ren T, Zuo Z (2019) Role of piperine in CNS diseases: pharmacodynamics, pharmacokinetics and drug interactions. Expert Opin Drug Metab Toxicol 15(10):849–867

Article  CAS  PubMed  Google Scholar 

Shao B, Cui C, Ji H, Tang J, Wang Z, Liu H, Qin M, Li X, Wu L (2015) Enhanced oral bioavailability of piperine by self-emulsifying drug delivery systems: in vitro, in vivo and in situ intestinal permeability studies. Drug Deliv 22(6):740–747

Article  CAS  PubMed  Google Scholar 

Lee SH, Kim HY, Back SY, Han HK (2018) Piperine-mediated drug interactions and formulation strategy for piperine: recent advances and future perspectives. Expert Opin Drug Metab Toxicol 14(1):43–57

Article  CAS  PubMed  Google Scholar 

Zaini E, Riska D, Oktavia MD, Ismed F, Fitriani L (2020) Improving dissolution rate of piperine by multicomponent crystal formation with saccharin. Res J Pharm Technolo 13(4):1928–1932

Article  Google Scholar 

Quijia CR, Chorilli M (2020) Characteristics, biological properties and analytical methods of piperine: a review. Crit Rev Anal Chem 50(1):62–77

Article  CAS  PubMed  Google Scholar 

Elzoghby AO, Helmy MW, Samy WM, Elgindy NA (2013) Spray-dried casein-based micelles as a vehicle for solubilization and controlled delivery of flutamide: formulation, characterization, and in vivo pharmacokinetics. Eur J Pharm Biopharm 84(3):487–496

Article  CAS  PubMed  Google Scholar 

Yokoyama M (2014) Polymeric micelles as drug carriers: their lights and shadows. J Drug Target 22(7):576–583

Article  CAS  PubMed  Google Scholar 

Wijiani N, Isadiartuti D, Rijal MA, Yusuf H (2020) Characterization and dissolution study of micellar curcumin-spray dried powder for oral delivery. Int J Nanomed 15:1787

Article  CAS  Google Scholar 

Tripathi AK, Ray AK, Mishra SK (2022) Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials. Beni-Suef Univ J Basic Appl Sci 11(1):16

Article  PubMed  PubMed Central  Google Scholar 

Mustafai A, Zubair M, Hussain A, Ullah A (2023) Recent progress in proteins-based micelles as drug delivery carriers. Polymers 15(4):836

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Liu L, Yuan M, Guo R (2013) Preparation and characterization of casein-stabilized gold nanoparticles for catalytic applications. Colloids Surf A 20(417):18–25

Article  Google Scholar 

Pateiro M, Gómez B, Munekata PE, Barba FJ, Putnik P, Kovačević DB, Lorenzo JM (2021) Nanoencapsulation of promising bioactive compounds to improve their absorption, stability, functionality and the appearance of the final food products. Molecules 26(6):1547

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elzoghby AO, El-Fotoh WS, Elgindy NA (2011) Casein-based formulations as promising controlled release drug delivery systems. J Control Release 153(3):206–216

Article  CAS  PubMed  Google Scholar 

Kumar V, Singh C, Singh A (2022) Neuroprotective potential of hydroalcoholic extract of Centella asiatica against 3-nitropropionic acid-induced Huntington’s like symptoms in adult zebrafish. Rejuvenation Res 25(6):260–274

Article  CAS  PubMed  Google Scholar 

Khanji AN, Michaux F, Petit J, Salameh D, Rizk T, Jasniewski J, Banon S (2018) Structure, gelation, and antioxidant properties of curcumin-doped casein micelle powder produced by spray-drying. Food Funct 9(2):971–981

Article  CAS  PubMed  Google Scholar 

Puri V, Chaudhary KR, Singh A, Singh C (2022) Inhalation potential of N-acetylcysteine loaded PLGA nanoparticles for the management of tuberculosis: in vitro lung deposition and efficacy studies. Curr Res Pharmacol Drug Discov 18:100084

Article  Google Scholar 

Khatak S, Mehta M, Awasthi R, Paudel KR, Singh SK, Gulati M, Hansbro NG, Hansbro PM, Dua K, Dureja H (2020) Solid lipid nanoparticles containing anti-tubercular drugs attenuate the Mycobacterium marinum infection. Tuberculosis 1(125):102008

Article  Google Scholar 

Imam SS, Alshehri S, Altamimi MA, Hussain A, Qamar W, Gilani SJ, Zafar A, Alruwaili NK, Alanazi S, Almutairy BK (2021) Formulation of piperine–chitosan-coated liposomes: characterization and in vitro cytotoxic evaluation. Molecules 26(11):3281

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wiprich MT, Zanandrea R, Altenhofen S, Bonan CD (2020) Influence of 3-nitropropionic acid on physiological and behavioral responses in zebrafish larvae and adults. Comp Biochem Physiol C: Toxicol Pharmacol 1(234):108772

Google Scholar 

Arora S, Kumar V, Kapil L, Agrawal AK, Singh A, Singh C (2023) Piperine loaded metal organic frameworks reverse doxorubicin induced chemobrain in adult zebrafish. J Control Release 1(355):259–272

Article  Google Scholar 

Sataa NS, Bakar NA, Hodin NA, Ramlan NF, Ibrahim WN (2020) Behavioral responses of Javanese medaka (Oryzias javanicus) versus zebrafish (Danio rerio) in open field test. Res Sq 23:1–24

Google Scholar 

Stewart A, Cachat JM, Suciu C, Hart PC, Gaikwad S, Utterback E, DiLeo J, Kalueff AV (2011) Intraperitoneal injection as a method of psychotropic drug delivery in adult zebrafish. In: Zebrafish neurobehavioral protocols. Humana Press, pp 169–179

Gupta T, Mullins MC (2010) Dissection of organs from the adult zebrafish. JoVE (J Visual Exp) 37:e1717

Google Scholar 

Wills E (1966) Mechanisms of lipid peroxide formation in animal tissues. Biochem J 99(3):667

Article  CAS  PubMed  PubMed Central  Google Scholar