Shank3 deficiency alters midbrain GABAergic neuron morphology, GABAergic markers and synaptic activity in primary striatal neurons

Puts NAJ, Wodka EL, Harris AD, Crocetti D, Tommerdahl M, Mostofsky SH, Edden RAE. Reduced GABA and altered somatosensory function in children with autism spectrum disorder. Autism Res. 2017;10(4):608–19. https://doi.org/10.1002/aur.1691. Epub 2016 Sep 9.

Article  PubMed  Google Scholar 

Parrella NF, Hill AT, Dipnall LM, Loke YJ, Enticott PG, Ford TC. Inhibitory dysfunction and social processing difficulties in autism: a comprehensive narrative review. J Psychiatr Res. 2024;169:113–25. Epub 2023 Nov 18.

Article  PubMed  Google Scholar 

Havranek T, Bacova Z, Bakos J. Oxytocin, GABA, and dopamine interplay in autism. Endocr Regul. 2024;58(1):105–14. https://doi.org/10.2478/enr-2024-0012

Article  PubMed  Google Scholar 

Zhu Y, Li H, Zhou L, Wu JY, Rao Y. Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex. Neuron. 1999;23(3):473–85. https://doi.org/10.1016/s0896-6273(00)80801-6

Article  CAS  PubMed  Google Scholar 

Tang X, Jaenisch R, Sur M. The role of GABAergic signalling in neurodevelopmental disorders. Nat Rev Neurosci. 2021;22(5):290–307. https://doi.org/10.1038/s41583-021-00443-x. Epub 2021 Mar 26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bouarab C, Thompson B, Polter AM. VTA GABA neurons at the interface of stress and reward. Front Neural Circuits. 2019;13:78. https://doi.org/10.3389/fncir.2019.00078

Article  CAS  PubMed  PubMed Central  Google Scholar 

Root DH, Barker DJ, Estrin DJ, Miranda-Barrientos JA, Liu B, Zhang S, Wang HL, Vautier F, Ramakrishnan C, Kim YS, Fenno L, Deisseroth K, Morales M. Distinct signaling by ventral tegmental area glutamate, GABA, and combinatorial Glutamate-GABA neurons in motivated behavior. Cell Rep. 2020;32(9):108094. https://doi.org/10.1016/j.celrep.2020.108094

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chuhma N, Oh SJ, Rayport S. The dopamine neuron synaptic map in the striatum. Cell Rep. 2023;42(3):112204. https://doi.org/10.1016/j.celrep.2023.112204. Epub 2023 Mar 2. PMID: 36867530; PMCID: PMC10657204.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Faget L, Oriol L, Lee WC, Zell V, Sargent C, Flores A, Hollon NG, Ramanathan D, Hnasko TS. Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types. Nat Commun. 2024;15(1):4233. https://doi.org/10.1038/s41467-024-48340-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peça J, Feliciano C, Ting JT, Wang W, Wells MF, Venkatraman TN, Lascola CD, Fu Z, Feng G. Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature. 2011;472(7344):437–42. https://doi.org/10.1038/nature09965. Epub 2011 Mar 20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bey AL, Wang X, Yan H, Kim N, Passman RL, Yang Y, Cao X, Towers AJ, Hulbert SW, Duffney LJ, Gaidis E, Rodriguiz RM, Wetsel WC, Yin HH, Jiang YH. Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors. Transl Psychiatry. 2018;8(1):94. https://doi.org/10.1038/s41398-018-0142-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reichova A, Bacova Z, Bukatova S, Kokavcova M, Meliskova V, Frimmel K, Ostatnikova D, Bakos J. Abnormal neuronal morphology and altered synaptic proteins are restored by oxytocin in autism-related SHANK3 deficient model. Mol Cell Endocrinol. 2020;518:110924. https://doi.org/10.1016/j.mce.2020.110924. Epub 2020 Jun 30.

Article  CAS  PubMed  Google Scholar 

Bukatova S, Renczes E, Reichova A, Filo J, Sadlonova A, Mravec B, Ostatnikova D, Bakos J, Bacova Z. Shank3 deficiency is associated with altered profile of neurotransmission markers in pups and adult mice. Neurochem Res. 2021;46(12):3342–55. https://doi.org/10.1007/s11064-021-03435-6. Epub 2021 Aug 28.

Article  CAS  PubMed  Google Scholar 

Mihalj D, Borbelyova V, Pirnik Z, Bacova Z, Ostatnikova D, Bakos J. Shank3 deficiency results in a reduction in GABAergic postsynaptic puncta in the olfactory brain areas. Neurochem Res. 2024;49(4):1008–16. https://doi.org/10.1007/s11064-023-04097-2. Epub 2024 Jan 6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhandage AK, Friedrich LM, Kanatani S, Jakobsson-Björkén S, Escrig-Larena JI, Wagner AK, Chambers BJ, Barragan A. GABAergic signaling in human and murine NK cells upon challenge with toxoplasma gondii. J Leukoc Biol. 2021;110(4):617–28. https://doi.org/10.1002/JLB.3HI0720-431R. Epub 2021 May 24.

Article  CAS  PubMed  Google Scholar 

Arsenault J, Gholizadeh S, Niibori Y, Pacey LK, Halder SK, Koxhioni E, Konno A, Hirai H, Hampson DR. FMRP expression levels in mouse central nervous system neurons determine behavioral phenotype. Hum Gene Ther. 2016;27(12):982–96. https://doi.org/10.1089/hum.2016.090

Article  CAS  PubMed  PubMed Central  Google Scholar 

Du Z, Tertrais M, Courtand G, Leste-Lasserre T, Cardoit L, Masmejean F, Halgand C, Cho YH, Garret M. Differential alteration in expression of striatal GABAAR subunits in mouse models of Huntington’s disease. Front Mol Neurosci. 2017;10:198. https://doi.org/10.3389/fnmol.2017.00198

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yoon S, Choi YC, Lee S, Jeong Y, Yoon J, Baek K. Induction of growth arrest by mir-542-3p that targets survivin. FEBS Lett. 2010;584(18):4048–52. https://doi.org/10.1016/j.febslet.2010.08.025

Article  CAS  PubMed  Google Scholar 

Bottermann M, Foss S, Caddy SL, Clift D, van Tienen LM, Vaysburd M, Cruickshank J, O’Connell K, Clark J, Mayes K, Higginson K, Lode HE, McAdam MB, Sandlie I, Andersen JT, James LC. Complement C4 prevents viral infection through capsid inactivation. Cell Host Microbe. 2019;25(4):617–e6297. https://doi.org/10.1016/j.chom.2019.02.016

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sato M, Nakai N, Fujima S, Choe KY, Takumi T. Social circuits and their dysfunction in autism spectrum disorder. Mol Psychiatry. 2023;28(8):3194–206. https://doi.org/10.1038/s41380-023-02201-0. Epub 2023 Aug 24.

Article  PubMed  PubMed Central  Google Scholar 

Cai J, Tong Q. Anatomy and function of ventral tegmental area glutamate neurons. Front Neural Circuits. 2022;16:867053. https://doi.org/10.3389/fncir.2022.867053

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chowdhury S, Matsubara T, Miyazaki T, Ono D, Fukatsu N, Abe M, Sakimura K, Sudo Y, Yamanaka A. GABA neurons in the ventral tegmental area regulate non-rapid eye movement sleep in mice. Elife. 2019;8:e44928. https://doi.org/10.7554/eLife.44928

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gantz SC, Bunzow JR, Williams JT. Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor. Neuron. 2013;78(5):807–12. https://doi.org/10.1016/j.neuron.2013.04.013

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morales M, Margolis EB. Ventral tegmental area: cellular heterogeneity, connectivity and behaviour. Nat Rev Neurosci. 2017;18(2):73–85. https://doi.org/10.1038/nrn.2016.165

Article  CAS  PubMed  Google Scholar 

Wang YZ, Perez-Rosello T, Smukowski SN, Surmeier DJ, Savas JN. Neuron type-specific proteomics reveals distinct Shank3 proteoforms in iSPNs and dSPNs lead to striatal synaptopathy in Shank3B-/- mice. Mol Psychiatry. 2024 Mar 14. https://doi.org/10.1038/s41380-024-02493-w. Epub ahead of print. Erratum in: Mol Psychiatry. 2024 Mar 28. https://doi.org/10.1038/s41380-024-02543-3.

Li W, Pozzo-Miller L. Dysfunction of the corticostriatal pathway in autism spectrum disorders. J Neurosci Res. 2020;98(11):2130–47. https://doi.org/10.1002/jnr.24560. Epub 2019 Nov 22.

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