Lauritano D, Moreo G, Della Vella F et al (2019) Oral health status and need for oral care in an aging population: a systematic review. Int J Environ Res Public Heal 16:4558–4580. https://doi.org/10.3390/ijerph16224558

Article  Google Scholar 

Foltyn P (2015) Ageing, dementia and oral health. Aust Dent J 60:86–94. https://doi.org/10.1111/adj.12287

Article  PubMed  Google Scholar 

Stewart R, Weyant RJ, Garcia ME et al (2013) Adverse oral health and cognitive decline: the health, aging and body composition study. J Am Geriatr Soc 61:177–184. https://doi.org/10.1111/jgs.12094

Article  PubMed  PubMed Central  Google Scholar 

Axelsson P, Nyström B, Lindhe J (2004) The long-term effect of a plaque control program on tooth mortality, caries and periodontal disease in adults: results after 30 years of maintenance. J Clin Periodontol 31:749–757. https://doi.org/10.1111/j.1600-051X.2004.00563.x

Article  CAS  PubMed  Google Scholar 

Cohen S, Berman LH, Blanco L et al (2006) A demographic analysis of vertical root fractures. J Endod 32:1160–1163. https://doi.org/10.1016/j.joen.2006.07.008

Article  PubMed  Google Scholar 

Fratzl P, Weinkamer R (2007) Nature’s hierarchical materials. Prog Mater Sci 52:1263–1334. https://doi.org/10.1016/j.pmatsci.2007.06.001

Article  CAS  Google Scholar 

An B, Wagner HD (2016) Role of microstructure on fracture of dentin. J Mech Behav Biomed Mater 59:527–537. https://doi.org/10.1016/j.jmbbm.2016.03.008

Article  CAS  PubMed  Google Scholar 

Bar-On B, Wagner HD (2012) Enamel and dentin as multi-scale bio-composites. J Mech Behav Biomed Mater 12:174–183. https://doi.org/10.1016/j.jmbbm.2012.03.007

Article  CAS  PubMed  Google Scholar 

Bertassoni LE (2017) Dentin on the nanoscale: hierarchical organization, mechanical behavior and bioinspired engineering. Dent Mater 33:637–649. https://doi.org/10.1016/j.dental.2017.03.008

Article  PubMed  PubMed Central  Google Scholar 

Nanci A (2014) Ten Cate’s oral histology: development, structure, and function. Mosby, St Louis

Google Scholar 

Fratzl P, Gupta HS, Paschalis EP et al (2004) Structure and mechanical quality of the collagen-mineral nano-composite in bone. J Mater Chem 14:2115–2123. https://doi.org/10.1039/b402005g

Article  CAS  Google Scholar 

Landis WJ, Hodgens KJ, Arena J et al (1996) Structural relations between collagen and mineral in bone as determined by high voltage electron microscopic tomography. Microsc Res Tech 33:192–202. https://doi.org/10.1002/(SICI)1097-0029(19960201)33:2%3c192::AID-JEMT9%3e3.0.CO;2-V

Article  CAS  PubMed  Google Scholar 

Jäger I, Fratzl P (2000) Mineralized collagen fibrils: a mechanical model with a staggered arrangement of mineral particles. Biophys J 79:1737–1746. https://doi.org/10.1016/S0006-3495(00)76426-5

Article  PubMed  PubMed Central  Google Scholar 

Weinkamer R, Fratzl P (2016) Solving conflicting functional requirements by hierarchical structuring—examples from biological materials. MRS Bull 41:667–671. https://doi.org/10.1557/mrs.2016.168

Article  Google Scholar 

Garberoglio R, Brännström M (1976) Scanning electron microscopic investigation of human dentinal tubules. Arch Oral Biol 21:355–362. https://doi.org/10.1016/S0003-9969(76)80003-9

Article  CAS  PubMed  Google Scholar 

Ryou H, Romberg E, Pashley DH et al (2011) Nanoscopic dynamic mechanical properties of intertubular and peritubular dentin. J Mech Behav Biomed Mater 7:3–16. https://doi.org/10.1016/j.jmbbm.2011.08.010

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goldberg M, Kulkarni AB, Young M et al (2011) Dentin: structure, composition and mineralization. Front Biosci-Elit 3:711–735. https://doi.org/10.2741/e281

Article  Google Scholar 

Solheim T (1992) Amount of secondary dentin as an indicator of age. Eur J Oral Sci 100:193–199. https://doi.org/10.1111/j.1600-0722.1992.tb01740.x

Article  CAS  Google Scholar 

Meinl A, Tangl S, Pernicka E et al (2007) On the applicability of secondary dentin formation to radiological age estimation in young adults. J Forensic Sci 52:438–441. https://doi.org/10.1111/j.1556-4029.2006.00377.x

Article  PubMed  Google Scholar 

Montoya C, Arango-Santander S, Peláez-Vargas A et al (2015) Effect of aging on the microstructure, hardness and chemical composition of dentin. Arch Oral Biol 60:1811–1820. https://doi.org/10.1016/j.archoralbio.2015.10.002

Article  CAS  PubMed  Google Scholar 

Kinney JH, Nalla RK, Ja P et al (2005) Age-related transparent root dentin: mineral concentration, crystallite size, and mechanical properties. Biomaterials 26:3363–3376. https://doi.org/10.1016/j.biomaterials.2004.09.004

Article  CAS  PubMed  Google Scholar 

Arola D, Reprogel RK (2005) Effects of aging on the mechanical behavior of human dentin. Biomaterials 26:4051–4061. https://doi.org/10.1016/j.biomaterials.2004.10.029

Article  CAS  PubMed  Google Scholar 

Ivancik J, Majd H, Bajaj D et al (2012) Contributions of aging to the fatigue crack growth resistance of human dentin. Acta Biomater 8:2737–2746. https://doi.org/10.1016/j.actbio.2012.03.046

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nazari A, Bajaj D, Zhang D et al (2009) Aging and the reduction in fracture toughness of human dentin. J Mech Behav Biomed Mater 2:550–559. https://doi.org/10.1016/j.jmbbm.2009.01.008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koester KJ, Ager JW, Ritchie RO (2008) The effect of aging on crack-growth resistance and toughening mechanisms in human dentin. Biomaterials 29:1318–1328. https://doi.org/10.1016/j.biomaterials.2007.12.008

Article  CAS  PubMed  Google Scholar 

Shinno Y, Ishimoto T, Saito M et al (2016) Comprehensive analyses of how tubule occlusion and advanced glycation end-products diminish strength of aged dentin. Sci Rep 6:1–10. https://doi.org/10.1038/srep19849

Article  CAS  Google Scholar 

Sakurai S (2017) Recent developments in polymer applications of synchrotron small-angle X-ray scattering. Polym Int 66:237–249. https://doi.org/10.1002/pi.5136

Article  CAS  Google Scholar 

Zaslansky P, Maerten A, Fratzl P (2013) Apatite alignment and orientation at the Angstrom and nanometer length scales shed light on the adaptation of dentine to whole tooth mechanical function. Bioinspir Biomim Nanobiomater 2:194–202. https://doi.org/10.1680/bbn.13.00007

Article  CAS  Google Scholar 

Seidel R, Gourrier A, Kerschnitzki M et al (2012) Synchrotron 3D SAXS analysis of bone nanostructure. Bioinspir Biomim Nanobiomater 1:123–131. https://doi.org/10.1680/bbn.11.00014

Article  Google Scholar 

Kinney JH, Pople JA, Marshall GW et al (2001) Collagen orientation and crystallite size in human dentin: a small angle X-ray scattering study. Calcif Tissue Int 69:31–37. https://doi.org/10.1007/s00223-001-0006-5

Article  CAS  PubMed  Google Scholar 

Märten A, Fratzl P, Paris O et al (2010) On the mineral in collagen of human crown dentine. Biomaterials 31:5479–5490. https://doi.org/10.1016/j.biomaterials.2010.03.030

Article  CAS  PubMed