Multi-trait Genome-Wide Analysis Identified 20 Novel Loci for Sarcopenia-Related Traits in UK Biobank

Patel HP, Syddall HE, Jameson K, Robinson S, Denison H, Roberts HC, Edwards M et al (2013) Prevalence of sarcopenia in community-dwelling older people in the UK using the European working group on sarcopenia in older people (EWGSOP) definition: findings from the Hertfordshire cohort study (HCS). Age Ageing 42:378–384

Article  PubMed  PubMed Central  Google Scholar 

Volpi E, Nazemi R, Fujita S (2004) Muscle tissue changes with aging. Curr Opin Clin Nutr Metab Care 7:405–410

Article  CAS  PubMed  PubMed Central  Google Scholar 

Klimentidis YC, Bea JW, Thompson P, Klimecki WT, Hu C, Wu G, Nicholas JS et al (2016) Genetic variant in ACVR2B is associated with lean mass. Med Sci Sports Exerc 48:1270–1275

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pei YF, Hu WZ, Yang XL, Wei XT, Feng GJ, Zhang H, Shen H et al (2019) Two functional variants at 6p21.1 were associated with lean mass. Skeletal Muscle 9:28

Article  PubMed  PubMed Central  Google Scholar 

Medina-Gomez C, Kemp JP, Dimou NL, Kreiner E, Chesi A, Zemel BS, Bønnelykke K et al (2017) Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus. Nat Commun 8:121

Article  PubMed  PubMed Central  Google Scholar 

Willems SM, Wright DJ, Day FR, Trajanoska K, Joshi PK, Morris JA, Matteini AM et al (2017) Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness. Nat Commun 8:16015

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sarnowski C, Chen H, Biggs ML, Wassertheil-Smoller S, Bressler J, Irvin MR, Ryan KA et al (2021) Identification of novel and rare variants associated with handgrip strength using whole genome sequence data from the NHLBI Trans-omics in precision medicine (TOPMed) program. PLoS ONE 16:e0253611

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jones G, Trajanoska K, Santanasto AJ, Stringa N, Kuo C-L, Atkins JL, Lewis JR et al (2021) Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women. Nat Commun 12:654

Article  CAS  PubMed  PubMed Central  Google Scholar 

Timmins IR, Zaccardi F, Nelson CP, Franks PW, Yates T, Dudbridge F (2020) Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival. Commun Biol 3:634

Article  PubMed  PubMed Central  Google Scholar 

Ben-Avraham D, Karasik D, Verghese J, Lunetta KL, Smith JA, Eicher JD, Vered R et al (2017) The complex genetics of gait speed: genome-wide meta-analysis approach. Aging 9:209–246

Article  PubMed  PubMed Central  Google Scholar 

Manini TM, Buford TW, Kairalla JA, McDermott MM, Fragoso CAV, Fielding RA, Hsu F et al (2018) Meta-analysis identifies mitochondrial DNA sequence variants associated with walking speed. GeroScience 40:497–511

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bulik-Sullivan B, Finucane HK, Anttila V, Gusev A, Day FR, Loh PR, Consortium R et al (2015) An atlas of genetic correlations across human diseases and traits. Nat Genet 47:1236–1241

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bulik-Sullivan BK, Loh P-R, Finucane HK, Ripke S, Yang J, Patterson N, Consortium SWGotPG et al (2015) LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet 47:291–295

Article  CAS  PubMed  PubMed Central  Google Scholar 

Turley P, Walters RK, Maghzian O, Okbay A, Lee JJ, Fontana MA, Nguyen-Viet TA et al (2018) Multi-trait analysis of genome-wide association summary statistics using MTAG. Nat Genet 50:229–237

Article  CAS  PubMed  PubMed Central  Google Scholar 

Watanabe K, Taskesen E, Van Bochoven A, Posthuma D (2017) Functional mapping and annotation of genetic associations with FUMA. Nature Commun 8(1):1826

Article  Google Scholar 

Taillon-Miller P, Bauer-Sardiña I, Saccone NL, Putzel J, Laitinen T, Cao A, Kere J et al (2000) Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28. Nat Genet 25:324–328

Article  CAS  PubMed  Google Scholar 

Chang D, Nalls MA, Hallgrímsdóttir IB, Hunkapiller J, Van Der Brug M, Cai F, Consortium IPsDG et al (2017) A meta-analysis of genome-wide association studies identifies 17 new Parkinson’s disease risk loci. Nat Genet 49:1511–1516

Article  CAS  PubMed  PubMed Central  Google Scholar 

Michailidou K, Lindström S, Dennis J, Beesley J, Hui S, Kar S, Lemaçon A et al (2017) Association analysis identifies 65 new breast cancer risk loci. Nature 551:92–94

Article  CAS  PubMed  PubMed Central  Google Scholar 

Milne RL, Kuchenbaecker KB, Michailidou K, Beesley J, Kar S, Lindström S, Hui S et al (2017) Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Nat Genet 49:1767–1778

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nicolae DL, Gamazon E, Zhang W, Duan S, Dolan ME, Cox NJ (2010) Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS. PLoS Genet 6:e1000888

Article  PubMed  PubMed Central  Google Scholar 

Gusev A, Lee SH, Trynka G, Finucane H, Vilhjálmsson BJ, Xu H, Zang C et al (2014) Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. Am J Hum Genet 95:535–552

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barbeira AN, Dickinson SP, Bonazzola R, Zheng J, Wheeler HE, Torres JM, Torstenson ES et al (2018) Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics. Nat Commun 9:1825

Article  PubMed  PubMed Central  Google Scholar 

Consortium G, Laboratory DACCLAWG, Group SMgAW, groups EGe, Fund NC, NIH/NCI, NIH/NHGRI et al (2017) Genetic effects on gene expression across human tissues. Nature 550:204–213

Article  Google Scholar 

Ward LD, Kellis M (2016) HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease. Nucleic Acids Res 44:D877–D881

Article  CAS  PubMed  Google Scholar 

Canela-Xandri O, Rawlik K, Tenesa A (2018) An atlas of genetic associations in UK Biobank. Nat Genet 50:1593–1599

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mullin BH, Tickner J, Zhu K, Kenny J, Mullin S, Brown SJ, Dudbridge F et al (2020) Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts. Genome Biol 21:80

Article  CAS  PubMed  PubMed Central  Google Scholar 

Savage DB, Agostini M, Barroso I, Gurnell M, Luan J, Meirhaeghe A, Harding A-H et al (2002) Digenic inheritance of severe insulin resistance in a human pedigree. Nat Genet 31:379–384

Article  CAS  PubMed  Google Scholar 

Savage DB, Zhai L, Ravikumar B, Choi CS, Snaar JE, McGuire AC, Wou SE et al (2008) A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice. PLoS Med 5(1):e27

Article  PubMed  PubMed Central  Google Scholar 

Shafiee G, Asgari Y, Soltani A, Larijani B, Heshmat R (2018) Identification of candidate genes and proteins in aging skeletal muscle (sarcopenia) using gene expression and structural analysis. PeerJ 6:e5239

Article 

留言 (0)

沒有登入
gif