Ström O, Borgström F, Kanis JA, Compston J, Cooper C, McCloskey EV, Jönsson B (2011) Osteoporosis: burden, health care provision and opportunities in the EU: a report prepared in collaboration with the international osteoporosis foundation (IOF) and the European federation of pharmaceutical industry associations (EFPIA). Arch Osteoporos 6:59–155. https://doi.org/10.1007/s11657-011-0060-1

Article  PubMed  Google Scholar 

Langdahl B, Ferrari S, Dempster DW (2016) Bone modeling and remodeling: potential as therapeutic targets for the treatment of osteoporosis. Ther Adv Musculoskelet Dis 8:225–235. https://doi.org/10.1177/1759720X16670154

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsukasaki M, Takayanagi H (2019) Osteoimmunology: evolving concepts in bone-immune interactions in health and disease. Nat Rev Immunol 19:626–642. https://doi.org/10.1038/s41577-019-0178-8

Article  CAS  PubMed  Google Scholar 

Ruscitti P, Cipriani P, Carubbi F, Liakouli V, Zazzeroni F, Di Benedetto P, Berardicurti O, Alesse E, Giacomelli R (2015) The role of IL-1β in the bone loss during rheumatic diseases. Mediators Inflamm 2015:782382. https://doi.org/10.1155/2015/782382

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Boyle WJ, Riggs BL (2000) The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res 15:2–12. https://doi.org/10.1359/jbmr.2000.15.1.2

Article  CAS  PubMed  Google Scholar 

Tanaka K, Hashizume M, Mihara M, Yoshida H, Suzuki M, Matsumoto Y (2014) Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model. Clin Exp Immunol 175:172–180. https://doi.org/10.1111/cei.12201

Article  CAS  PubMed  PubMed Central  Google Scholar 

Du D, Zhou Z, Zhu L, Hu X, Lu J, Shi C, Chen F, Chen A (2018) TNF-α suppresses osteogenic differentiation of MSCs by accelerating P2Y2 receptor in estrogen-deficiency induced osteoporosis. Bone 117:161–170. https://doi.org/10.1016/j.bone.2018.09.012

Article  CAS  PubMed  Google Scholar 

Liu H, Dong Y, Gao Y, Zhao L, Cai C, Qi D, Zhu M, Zhao L, Liu C, Guo F, Xiao J, Huang H (2019) Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss. J Cell Physiol 234:11009–11022. https://doi.org/10.1002/jcp.27924

Article  CAS  PubMed  Google Scholar 

Saxena Y, Routh S, Mukhopadhaya A (2021) Immunoporosis: role of innate immune cells in osteoporosis. Front Immunol 12:687037. https://doi.org/10.3389/fimmu.2021.687037

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu D, Cline-Smith A, Shashkova E, Perla A, Katyal A, Aurora R (2021) T-Cell mediated inflammation in postmenopausal osteoporosis. Front Immunol 12:687551. https://doi.org/10.3389/fimmu.2021.687551

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sapir-Koren R, Livshits G (2017) Postmenopausal osteoporosis in rheumatoid arthritis: the estrogen deficiency-immune mechanisms link. Bone 103:102–115. https://doi.org/10.1016/j.bone.2017.06.020

Article  PubMed  Google Scholar 

Blaschke M, Koepp R, Cortis J, Komrakova M, Schieker M, Hempel U, Siggelkow H (2018) IL-6, IL-1β, and TNF-α only in combination influence the osteoporotic phenotype in Crohn’s patients via bone formation and bone resorption. Adv Clin Exp Med 27:45–56. https://doi.org/10.17219/acem/67561

Article  PubMed  Google Scholar 

Shaiykova A, Pasquet A, Goujard C, Lion G, Durand E, Bayan T, Lachâtre M, Choisy P, Ajana F, Bourdic K, Viget N, Riff B, Quertainmont Y, Cortet B, Boufassa F, Chéret A (2018) Reduced bone mineral density among HIV-infected, virologically controlled young men: prevalence and associated factors. AIDS 32:2689–2696. https://doi.org/10.1097/QAD.0000000000002001

Article  PubMed  Google Scholar 

Hooi JKY, Lai WY, Ng WK, Suen MMY, Underwood FE, Tanyingoh D, Malfertheiner P, Graham DY, Wong VWS, Wu JCY, Chan FKL, Sung JJY, Kaplan GG, Ng SC (2017) Global prevalence of helicobacter pylori infection: systematic review and meta-analysis. Gastroenterology 153:420–429. https://doi.org/10.1053/j.gastro.2017.04.022

Article  PubMed  Google Scholar 

Robinson K, Atherton JC (2021) The spectrum of Helicobacter-mediated diseases. Annu Rev Pathol 16:123–144. https://doi.org/10.1146/annurev-pathol-032520-024949

Article  CAS  PubMed  Google Scholar 

Dincă AL, Meliț LE, Mărginean CO (2022) Old and new aspects of H. pylori-associated inflammation and gastric cancer. Children (Basel) 9:1083. https://doi.org/10.3390/children9071083

Article  PubMed  Google Scholar 

Bagheri V, Memar B, Momtazi AA, Sahebkar A, Gholamin M, Abbaszadegan MR (2018) Cytokine networks and their association with Helicobacter pylori infection in gastric carcinoma. J Cell Physiol 233:2791–2803. https://doi.org/10.1002/jcp.25822

Article  CAS  PubMed  Google Scholar 

Kanis JA (2002) Diagnosis of osteoporosis and assessment of fracture risk. Lancet 359:1929–1936. https://doi.org/10.1016/S0140-6736(02)08761-5

Article  PubMed  Google Scholar 

Kakehasi AM, Rodrigues CB, Carvalho AV, Barbosa AJ (2009) Chronic gastritis and bone mineral density in women. Dig Dis Sci 54:819–824. https://doi.org/10.1007/s10620-008-0417-5

Article  PubMed  Google Scholar 

Kim HW, Kim YH, Han K, Nam GE, Kim GS, Han BD, Lee A, Ahn JY, Ko BJ (2014) Atrophic gastritis: a related factor for osteoporosis in elderly women. PLoS ONE 9:e101852. https://doi.org/10.1371/journal.pone.0101852

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mizuno S, Matsui D, Watanabe I, Ozaki E, Kuriyama N, Watanabe Y (2015) Serologically determined gastric mucosal condition is a predictive factor for osteoporosis in Japanese men. Dig Dis Sci 60:2063–2069. https://doi.org/10.1007/s10620-015-3576-1

Article  CAS  PubMed  Google Scholar 

Ye YF, Chen YH, Hong D, Jiesisibieke ZL, Tung TH, Zhang MX (2022) Association of Helicobacter pylori infection with osteoporosis risk in a physical examination population. Arch Osteoporos 17:35. https://doi.org/10.1007/s11657-022-01074-0

Article  PubMed  Google Scholar 

Kim TJ, Lee H, Min YW, Min BH, Lee JH, Rhee PL, Kim JJ (2021) Cohort study of Helicobacter pylori infection and the risk of incident osteoporosis in women. J Gastroenterol Hepatol 36:657–663. https://doi.org/10.1111/jgh.15181

Article  PubMed  Google Scholar 

Wang T, Li X, Zhang Q, Ge B, Zhang J, Yu L, Cai T, Zhang Y, Xiong H (2019) Relationship between Helicobacter pylori infection and osteoporosis: a systematic review and meta-analysis. BMJ Open 9:e027356. https://doi.org/10.1136/bmjopen-2018-027356

Article  PubMed  PubMed Central  Google Scholar 

Gennari L, Merlotti D, Figura N, Mingiano C, Franci MB, Lucani B, Picchioni T, Alessandri M, Campagna MS, Gonnelli S, Bianciardi S, Materozzi M, Caffarelli C, Gonnelli S, Nuti R (2021) Infection by CagA-positive Helicobacter pylori strains and bone fragility: a prospective cohort study. J Bone Miner Res 36:80–89. https://doi.org/10.1002/jbmr.4162

Article  CAS  PubMed  Google Scholar 

Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T (2010) Cohort profile: research on osteoarthritis/osteoporosis against disability (ROAD) study. Int J Epidemiol 39:988–995. https://doi.org/10.1093/ije/dyp276

Article  PubMed  Google Scholar 

Inoue I, Yoshimura N, Iidaka T, Horii C, Muraki S, Oka H, Kawaguchi H, Akune T, Maekita T, Mure K, Nakamura K, Tanaka S, Ichinose M (2023) Trends in the prevalence of atrophic gastritis and Helicobacter pylori infection over a 10-year period in Japan: the ROAD study 2005–2015. Mol Clin Oncol 19:53. https://doi.org/10.3892/mco.2023.2649

Article  PubMed  PubMed Central  Google Scholar 

Ichinose M, Miki K, Furihata C, Kageyama T, Hayashi R, Niwa H, Oka H, Matsushima T, Takahashi K (1982) Radioimmunoassay of serum group I and group II pepsinogens in normal controls and patients with va