Ahmed OM, Saleh AS, Ahmed EA, Ghoneim MM, Ebrahim HA, Abdelgawad MA, Abdel-Gabbar M (2023) Efficiency of bone marrow-derived mesenchymal stem cells and hesperetin in the treatment of streptozotocin-induced type 1 diabetes in wistar rats. Pharmaceuticals (Basel) 16

Al-Shahrour F, Carbonell J, Minguez P, Goetz S, Conesa A, Tárraga J, Medina I, Alloza E, Montaner D, Dopazo J (2008) Babelomics: advanced functional profiling of transcriptomics, proteomics and genomics experiments. Nucleic Acids Res 36:W341-346

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anastasi E, Campese AF, Bellavia D, Bulotta A, Balestri A, Pascucci M, Checquolo S, Gradini R, Lendahl U, Frati L et al (2003) Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes. J Immunol 171:4504–4511

Article  CAS  PubMed  Google Scholar 

Anderson KA, Ribar TJ, Lin F, Noeldner PK, Green MF, Muehlbauer MJ, Witters LA, Kemp BE, Means AR (2008) Hypothalamic CaMKK2 contributes to the regulation of energy balance. Cell Metab 7:377–388

Article  CAS  PubMed  Google Scholar 

Atalay M, Oksala NK, Laaksonen DE, Khanna S, Nakao C, Lappalainen J, Roy S, Hänninen O, Sen CK (2004) Exercise training modulates heat shock protein response in diabetic rats. J Appl Physiol 97:605–611

Article  CAS  PubMed  Google Scholar 

Auger C, Kajimura S (2023) Adipose tissue remodeling in pathophysiology. Annu Rev Pathol 18:71–93

Article  CAS  PubMed  Google Scholar 

Benioudakis ES, Karlafti E, Georgiou ED, Kalaitzaki A, Kaiafa G, Savopoulos C, Didangelos T (2023) Diabetes mellitus type 1 during COVID-19: psychological symptoms and eating attitudes. Curr Diabetes Rev 19:e160522204817

Article  CAS  PubMed  Google Scholar 

Berndt J, Kovacs P, Ruschke K, Klöting N, Fasshauer M, Schön MR, Körner A, Stumvoll M, Blüher M (2007) Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes. Diabetologia 50:1472–1480

Article  CAS  PubMed  Google Scholar 

Blagov AV, Summerhill VI, Sukhorukov VN, Popov MA, Grechko AV, Orekhov AN (2023) Type 1 diabetes mellitus: inflammation, mitophagy, and mitochondrial function. Mitochondrion 72:11–21

Article  CAS  PubMed  Google Scholar 

Burkart V, Germaschewski L, Schloot NC, Bellmann K, Kolb H (2008) Deficient heat shock protein 70 response to stress in leukocytes at onset of type 1 diabetes. Biochem Biophys Res Commun 369:421–425

Article  CAS  PubMed  Google Scholar 

Di Y, Pan W, Li X (2015) Serum myosin light chain kinase in type 2 diabetes mellitus: a cross-sectional study. Ann Clin Lab Sci 45:54–57

CAS  PubMed  Google Scholar 

Ergin S, Kherad N, Alagoz M (2022) RNA sequencing and its applications in cancer and rare diseases. Mol Biol Rep 49:2325–2333

Article  CAS  PubMed  PubMed Central  Google Scholar 

Frontera WR, Ochala J (2015) Skeletal muscle: a brief review of structure and function. Calcif Tissue Int 96:183–195

Article  CAS  PubMed  Google Scholar 

Ge Q, Feng F, Liu L, Chen L, Lv P, Ma S, Chen K, Yao Q (2020) RNA-Seq analysis of the pathogenesis of STZ-induced male diabetic mouse liver. J Diabetes Complications 34:107444

Article  PubMed  Google Scholar 

Gerazova-Efremova K, Dinevska-Kjovkarovska S, Miova B (2019) Heat-shock protein 70-mediated heat preconditioning attenuates hepatic carbohydrate and oxidative disturbances in rats with type 1 diabetes. Can J Diabetes 43:345–353

Article  PubMed  Google Scholar 

Götz S, García-Gómez JM, Terol J, Williams TD, Nagaraj SH, Nueda MJ, Robles M, Talón M, Dopazo J, Conesa A (2008) High-throughput functional annotation and data mining with the Blast2GO suite. Nucleic Acids Res 36:3420–3435

Article  PubMed  PubMed Central  Google Scholar 

Heidarisasan S, Ziamajidi N, Karimi J, Abbasalipourkabir R (2018) Effects of insulin-loaded chitosan-alginate nanoparticles on RAGE expression and oxidative stress status in the kidney tissue of rats with type 1 diabetes. Iran J Basic Med Sci 21:1035–1042

PubMed  PubMed Central  Google Scholar 

Kedra D, Seroussi E, Fransson I, Trifunovic J, Clark M, Lagercrantz J, Blennow E, Mehlin H, Dumanski J (1997) The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13. Hum Genet 100:611–619

Article  CAS  PubMed  Google Scholar 

Korányi L, Hegedüs E, Péterfal E, Kurucz I (2004) The role of hsp60 and hsp70 kDa heat shock protein families in different types of diabetes mellitus. Orv Hetil 145:467–472

PubMed  Google Scholar 

Li X, Wang CY (2021) From bulk, single-cell to spatial RNA sequencing. Int J Oral Sci 13:36

Article  PubMed  PubMed Central  Google Scholar 

Li W, Huang E, Gao S (2017) Type 1 diabetes mellitus and cognitive impairments: a systematic review. J Alzheimers Dis 57:29–36

Article  CAS  PubMed  Google Scholar 

Lin H, Ma X, Sun Y, Peng H, Wang Y, Thomas SS, Hu Z (2022) Decoding the transcriptome of denervated muscle at single-nucleus resolution. J Cachexia Sarcopenia Muscle 13:2102–2117

Article  PubMed  PubMed Central  Google Scholar 

Lindholm ME, Huss M, Solnestam BW, Kjellqvist S, Lundeberg J, Sundberg CJ (2014) The human skeletal muscle transcriptome: sex differences, alternative splicing, and tissue homogeneity assessed with RNA sequencing. FASEB J 28:4571–4581

Article  CAS  PubMed  Google Scholar 

Liu HK, Hung TM, Huang HC, Lee IJ, Chang CC, Cheng JJ, Lin LC, Huang C (2015) Bai-Hu-Jia-Ren-Shen-Tang Decoction reduces fatty liver by activating AMP-activated protein kinase in vitro and in vivo. Evid Based Complement Altern Med 2015:651734

Article  Google Scholar 

Lu HF, Lai YH, Huang HC, Lee IJ, Lin LC, Liu HK, Tien HH, Huang C (2020) Ginseng-plus-Bai-Hu-Tang ameliorates diet-induced obesity, hepatic steatosis, and insulin resistance in mice. J Ginseng Res 44:238–246

Article  PubMed  Google Scholar 

Ma L, Mondal AK, Murea M, Sharma NK, Tönjes A, Langberg KA, Das SK, Franks PW, Kovacs P, Antinozzi PA et al (2011) The effect of ACACB cis-variants on gene expression and metabolic traits. PLoS ONE 6:e23860

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maniyadath B, Zhang Q, Gupta RK, Mandrup S (2023) Adipose tissue at single-cell resolution. Cell Metab 35:386–413

Article  CAS  PubMed  PubMed Central  Google Scholar 

Matsukawa T, Yagi T, Uchida T, Sakai M, Mitsushima M, Naganuma T, Yano H, Inaba Y, Inoue H, Yanagida K et al. (2023) Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models. JCI Insight 8

Min T, Bain SC (2023) Emerging drugs for the treatment of type 1 diabetes mellitus: a review of phase 2 clinical trials. Expert Opin Emerg Drugs 28:1–15

Article  PubMed  Google Scholar 

Misra S, Shukla AK (2023) Teplizumab: Type 1 diabetes mellitus preventable? Eur J Clin Pharmacol 79:609–616

Article  CAS  PubMed  Google Scholar 

Moriggi M, Belloli S, Barbacini P, Murtaj V, Torretta E, Chaabane L, Canu T, Penati S, Malosio ML, Esposito A et al. (2021) Skeletal muscle proteomic profile revealed gender-related metabolic responses in a diet-induced obesity animal model. Int J Mol Sci 22

Petersen MC, Shulman GI (2018) Mechanisms of insulin action and insulin resistance. Physiol Rev 98:2133–2223

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rasouli M, Jafari-Khataylou Y, Ashrafi-Helan J (2018) Carbenoxolone could deteriorate streptozotocin-induced diabetes through induction of heat shock protein 70 and IFN-γ in C57BL/6 Mice. Iran J Allergy Asthma Immunol 17:564–573

PubMed  Google Scholar 

Redondo MJ, Morgan NG (2023) Heterogeneity and endotypes in type 1 diabetes mellitus. Nat Rev Endocrinol 19:542–554

Article  PubMed  Google Scholar 

Riancho JA, Vázquez L, García-Pérez MA, Sainz J, Olmos JM, Hernández JL, Pérez-López J, Amado JA, Zarrabeitia MT, Cano A et al (2011) Association of ACACB polymorphisms with obesity and diabetes. Mol Genet Metab 104:670–676