Identification of genetic loci enriched in obese or lean T2D cases in the Korean population

Ahn Y, Lee H, Cho YS (2020) Identification of Genetic Variants for Female Obesity and evaluation of the causal role of genetically defined obesity in polycystic ovarian syndrome. Diabetes Metab Syndr Obes 13:4311–4322

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15:539–553

Article  CAS  PubMed  Google Scholar 

Casana E, Jimenez V, Sacristan V, Munoz S, Jambrina C, Rodo J, Garcia M, Mallol C, Leon X, Franckhauser S et al (2021) BMP7 overexpression in adipose tissue induces white adipogenesis and improves insulin sensitivity in ob/ob mice. Int J Obes (Lond) 45:449–460

Article  CAS  PubMed  Google Scholar 

Cauchi S, Choquet H, Gutierrez-Aguilar R, Capel F, Grau K, Proenca C, Dina C, Duval A, Balkau B, Marre M et al (2008a) Effects of TCF7L2 polymorphisms on obesity in European populations. Obes (Silver Spring) 16:476–482

Article  CAS  Google Scholar 

Cauchi S, Nead KT, Choquet H, Horber F, Potoczna N, Balkau B, Marre M, Charpentier G, Froguel P, Meyre D (2008b) The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies. BMC Med Genet 9:45

Article  PubMed  PubMed Central  Google Scholar 

Chan JC, Malik V, Jia W, Kadowaki T, Yajnik CS, Yoon KH, Hu FB (2009) Diabetes in Asia: epidemiology, risk factors, and pathophysiology. JAMA 301:2129–2140

Article  CAS  PubMed  Google Scholar 

Cheng L, Zhuang H, Ju H, Yang S, Han J, Tan R, Hu Y (2019) Exposing the Causal Effect of Body Mass Index on the risk of type 2 diabetes Mellitus: a mendelian randomization study. Front Genet 10:94

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cho YS, Go MJ, Kim YJ, Heo JY, Oh JH, Ban HJ, Yoon D, Lee MH, Kim DJ, Park M et al (2009) A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet 41:527–534

Article  CAS  PubMed  Google Scholar 

Cho YS, Lee JY, Park KS, Nho CW (2012) Genetics of type 2 diabetes in east Asian populations. Curr Diab Rep 12:686–696

Article  PubMed  Google Scholar 

Christiansen CE, Arathimos R, Pain O, Molokhia M, Bell JT, Lewis CM (2023) Stratified genome-wide association analysis of type 2 diabetes reveals subgroups with genetic and environmental heterogeneity. Hum Mol Genet 32:2638–2645

Article  CAS  PubMed  PubMed Central  Google Scholar 

Corbin LJ, Richmond RC, Wade KH, Burgess S, Bowden J, Smith GD, Timpson NJ (2016) BMI as a modifiable risk factor for type 2 diabetes: refining and understanding causal estimates using mendelian randomization. Diabetes 65:3002–3007

Article  CAS  PubMed  Google Scholar 

Daitoku H, Hatta M, Matsuzaki H, Aratani S, Ohshima T, Miyagishi M, Nakajima T, Fukamizu A (2004) Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A 101:10042–10047

Article  CAS  PubMed  PubMed Central  Google Scholar 

DeForest N, Majithia AR (2022) Genetics of type 2 diabetes: implications from large-scale studies. Curr Diab Rep 22:227–235

Article  CAS  PubMed  PubMed Central  Google Scholar 

Freeman AM, Acevedo LA, Pennings N (2023) Insulin resistance. StatPearls. Treasure Island (FL) ineligible companies. Disclosure: Luis Acevedo declares no relevant financial relationships with ineligible companies. Nicholas Pennings declares no relevant financial relationships with ineligible companies., Retrieved August 17, 2023 from https://www.ncbi.nlm.nih.gov/books/NBK507839/

Goyal R, Singhal M, Jialal I (2023) Type 2 diabetes. StatPearls. Treasure Island (FL) ineligible companies. Disclosure: Mayank Singhal declares no relevant financial relationships with ineligible companies. Ishwarlal Jialal declares no relevant financial relationships with ineligible companies., Retrieved Jun 23, 2023 from https://www.ncbi.nlm.nih.gov/books/NBK513253/

Guey LT, Kravic J, Melander O, Burtt NP, Laramie JM, Lyssenko V, Jonsson A, Lindholm E, Tuomi T, Isomaa B et al (2011) Power in the phenotypic extremes: a simulation study of power in discovery and replication of rare variants. Genet Epidemiol 35:236–246

Article  PubMed  Google Scholar 

Hatzfeld M, Nachtsheim C (1996) Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins. J Cell Sci 109(Pt 11):2767–2778

Article  CAS  PubMed  Google Scholar 

He L, Naik K, Meng S, Cao J, Sidhaye AR, Ma A, Radovick S, Wondisford FE (2012) Transcriptional co-activator p300 maintains basal hepatic gluconeogenesis. J Biol Chem 287:32069–32077

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu FB (2011) Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care 34:1249–1257

Article  PubMed  PubMed Central  Google Scholar 

Imamura M, Maeda S (2011) Genetics of type 2 diabetes: the GWAS era and future perspectives [Review]. Endocr J 58:723–739

Article  CAS  PubMed  Google Scholar 

Jeyaratnaganthan N, Hojlund K, Kroustrup JP, Larsen JF, Bjerre M, Levin K, Beck-Nielsen H, Frago S, Hassan AB, Flyvbjerg A et al (2010) Circulating levels of insulin-like growth factor-II/mannose-6-phosphate receptor in obesity and type 2 diabetes. Growth Horm IGF Res 20:185–191

Article  CAS  PubMed  Google Scholar 

Kim YJ, Cho YS (2023) Genetic association study identifies genetic variants for non-alcoholic fatty liver without comorbidities in the Korean population. Genes Genomics 45:847–854

Article  CAS  PubMed  Google Scholar 

Kim JY, Cho YS (2024) Identification of shared genetic risks underlying metabolic syndrome and its related traits in the Korean population. Front Genet 15:1417262

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim YJ, Go MJ, Hu C, Hong CB, Kim YK, Lee JY, Hwang JY, Oh JH, Kim DJ, Kim NH et al (2011) Large-scale genome-wide association studies in East asians identify new genetic loci influencing metabolic traits. Nat Genet 43:990–995

Article  CAS  PubMed  Google Scholar 

Kim Y, Han BG, KoGES g (2017) Cohort profile: the Korean genome and epidemiology study (KoGES) consortium. Int J Epidemiol 46:e20

Article  PubMed  Google Scholar 

Kong S, Cho YS (2019) Identification of female-specific genetic variants for metabolic syndrome and its component traits to improve the prediction of metabolic syndrome in females. BMC Med Genet 20:99

Article  PubMed  PubMed Central  Google Scholar 

Lee JW, Brancati FL, Yeh HC (2011) Trends in the prevalence of type 2 diabetes in asians versus whites: results from the United States National Health Interview Survey, 1997–2008. Diabetes Care 34:353–357

Article  PubMed  PubMed Central  Google Scholar 

Lee KL, Silvestre MP, AlSaud NH, Fogelholm M, Raben A, Poppitt SD (2021) Investigating IGF-II and IGF2R serum markers as predictors of body weight loss following an 8-week acute weight loss intervention: PREVIEW sub-study. Obes Res Clin Pract 15:42–48

Article  PubMed  Google Scholar 

Lee Y, Kim YA, Seo JH (2022) Causal Association of Obesity and dyslipidemia with type 2 diabetes: a two-sample mendelian randomization study. Genes (Basel) 13(12):2407

Article  CAS  PubMed  Google Scholar 

Li J, Wei J, Xu P, Yan M, Li J, Chen Z, Jin T (2016) Impact of diabetes-related gene polymorphisms on the clinical characteristics of type 2 diabetes Chinese Han population. Oncotarget 7:85464–85471

Article  PubMed  PubMed Central  Google Scholar 

Li K, Qiu C, Sun P, Liu DC, Wu TJ, Wang K, Zhou YC, Chang XA, Yin Y, Chen F et al (2019) Ets1-Mediated acetylation of FoxO1 is critical for gluconeogenesis regulation during feed-fast cycles. Cell Rep 26:2998–3010 e2995

Article  CAS  PubMed  Google Scholar 

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