Vaduganathan, M., Mensah, G.A., Turco, J.V., Fuster, V., and Roth, G.A., The global burden of cardiovascular diseases and risk: A compass for future health, J. Am. Coll. Cardiol., 2022, vol. 80, no. 25, pp. 2361–2371. https://doi.org/10.1016/j.jacc.2022.11.005

Article  PubMed  Google Scholar 

World Health Organization, World Health Statistics 2023: Monitoring Health for the SDGs, Sustainable Development Goals, Geneva, 2023.

Google Scholar 

Perna, M. and Hewlings, S., Saturated fatty acid chain length and risk of cardiovascular disease: A systematic review, Nutrients, 2022, vol. 15, no. 1, p. 30. https://doi.org/10.3390/nu15010030

Article  CAS  PubMed  PubMed Central  Google Scholar 

Picard, F. and Steg, P.G., Cardiovascular disease risk reduction in mild-moderate hypertriglyceridemia: Integrating prescription of omega-3 with standard treatment, Curr. Atheroscler. Rep., 2021, vol. 23, no. 6, p. 27. https://doi.org/10.1007/s11883-021-00919-2

Article  CAS  PubMed  Google Scholar 

Abdelhamid, A.S., Martin, N., Bridges, C., Brainard, J.S., Wang, X., Brown, T.J., Hanson, S., Ji-moh, O.F., Ajabnoor, S.M., Deane, K.H., Song, F., and Hooper, L., Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease, Cochrane Database Syst. Rev., 2018, vol. 11, no. 11, p. CD012345. https://doi.org/10.1002/14651858.CD012345.pub3

Article  PubMed  Google Scholar 

Shi, Z., He, Z., and Wang, D.W., CYP450 epoxygenase metabolites, epoxyeicosatrienoic acids, as novel anti-inflammatory mediators, Molecules, 2022, vol. 27, no. 12, p. 3873. https://doi.org/10.3390/molecules27123873

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jamieson, K.L., Endo, T., Darwesh, A.M., Samokhvalov, V., and Seubert, J.M., Cytochrome P450-derived eicosanoids and heart function, Pharmacol. Ther., 2017, vol. 179, pp. 47–83. https://doi.org/10.1016/j.pharmthera.2017.05.005

Article  CAS  PubMed  Google Scholar 

Zhou, Y., Khan, H., Xiao, J., and Cheang, W.S., Effects of arachidonic acid metabolites on cardiovascular health and disease, Int. J. Mol. Sci., 2021, vol. 22, no. 21, p. 12029. https://doi.org/10.3390/ijms222112029

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yamaguchi, A., Botta, E., and Holinstat, M., Eicosanoids in inflammation in the blood and the vessel, Front. Pharmacol., 2022, vol. 13, p. 997403. https://doi.org/10.3389/fphar.2022.997403

Article  CAS  PubMed  PubMed Central  Google Scholar 

Calder, P.C., Eicosanoids, Essays Biochem., 2020, vol. 64, no. 3, pp. 423–441. https://doi.org/10.1042/EBC20190083

Article  CAS  PubMed  Google Scholar 

Wang, T., Fu, X., Chen, Q., Patra, J.K., Wang, D., Wang, Z., and Gai, Z., Arachidonic acid metabolism and kidney inflammation, Int. J. Mol. Sci., 2019, vol. 20, no. 15, p. 3683. https://doi.org/10.3390/ijms20153683

Article  CAS  PubMed  PubMed Central  Google Scholar 

Badimon, L., Vilahur, G., Rocca, B., and Patrono, C., The key contribution of platelet and vascular arachidonic acid metabolism to the pathophysiology of atherothrombosis, Cardiovasc. Res., 2021, vol. 117, no. 9, pp. 2001–2015. https://doi.org/10.1093/cvr/cvab003

Article  CAS  PubMed  Google Scholar 

Wang, B., Wu, L., Chen, J., Dong, L., Chen, C., Wen, Z., Hu, J., Fleming, I., and Wang, D.W., Metabolism pathways of arachidonic acids: Mechanisms and potential therapeutic targets, Signal Transduction Targeted Ther., 2021, vol. 6, no. 1, p. 94. https://doi.org/10.1038/s41392-020-00443-w

Article  CAS  Google Scholar 

Esser-von Bieren, J., Eicosanoids in tissue repair, Immunol. Cell Biol., 2019, vol. 97, no. 3, pp. 279–288. https://doi.org/10.1111/imcb.12226

Article  CAS  PubMed  Google Scholar 

Zhang, T., Au Yeung, S.L., and Schooling, C.M., Associations of arachidonic acid synthesis with cardiovascular risk factors and relation to ischemic heart disease and stroke: A univariable and multivariable Mendelian randomization study, Nutrients, 2021, vol. 13, no. 5, p. 1489. https://doi.org/10.3390/nu13051489

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, T., Zhao, J.V., and Schooling, C.M., The associations of plasma phospholipid arachidonic acid with cardiovascular diseases: A Mendelian randomization study, EBioMedicine, 2021, vol. 63, p. 103189. https://doi.org/10.1016/j.ebiom.2020.103189

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumar, A., Behl, T., Jamwal, S., Kaur, I., Sood, A., and Kumar, P., Exploring the molecular approach of COX and LOX in Alzheimer’s and Parkinson’s disorder, Mol. Biol. Rep., 2020, vol. 47, no. 12, pp. 9895–9912. https://doi.org/10.1007/s11033-020-06033-x

Article  CAS  PubMed  Google Scholar 

Wang, D. and Dubois, R.N., Eicosanoids and cancer, Nat. Rev. Cancer, 2010, vol. 10, no. 3, pp. 181–193. https://doi.org/10.1038/nrc2809

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wallace, J.L., Eicosanoids in the gastrointestinal tract, Br. J. Pharmacol., 2019, vol. 176, no. 8, pp. 1000–1008. https://doi.org/10.1111/bph.14178

Article  CAS  PubMed  Google Scholar 

Westphal, C., Konkel, A., and Schunck, W.H., Cytochrome p450 enzymes in the bioactivation of polyunsaturated Fatty acids and their role in cardiovascular disease, Adv. Exp. Med. Biol., 2015, vol. 851, pp. 151–187. https://doi.org/10.1007/978-3-319-16009-2_6

Article  CAS  PubMed  Google Scholar 

Pavek, P. and Dvorak, Z., Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues, Curr. Drug Metab., 2008, vol. 9, no. 2, pp. 129–143. https://doi.org/10.2174/138920008783571774

Article  CAS  PubMed  Google Scholar 

Chaudhary, K.R., Batchu, S.N., and Seubert, J.M., Cytochrome P450 enzymes and the heart, IUBMB Life, 2009, vol. 61, no. 10, pp. 954–960. https://doi.org/10.1002/iub.241

Article  CAS  PubMed  Google Scholar 

Serhan, C.N. and Petasis, N.A., Resolvins and protectins in inflammation resolution, Chem. Rev., 2011, vol. 111, no. 10, pp. 5922–5943. https://doi.org/10.1021/cr100396c

Article  CAS  PubMed  PubMed Central  Google Scholar 

Onodera, T., Fukuhara, A., Shin, J., Hayakawa, T., Otsuki, M., and Shimomura, I., Eicosapentaenoic acid and 5-HEPE enhance macrophage-mediated Treg induction in mice, Sci. Rep., 2017, vol. 7, no. 1, p. 4560. https://doi.org/10.1038/s41598-017-04474-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Colombero, C., Cardenas, S., Venara, M., Martin, A., Pennisi, P., Barontini, M., and Nowicki, S., Cytochrome 450 metabolites of arachidonic acid (20‑HETE, 11,12-EET and 14,15-EET) promote pheochromocytoma cell growth and tumor associated angiogenesis, Biochimie, 2020, vols. 171–172, pp. 147–157. https://doi.org/10.1016/j.biochi.2020.02.014

Article  CAS  PubMed  Google Scholar 

Xu, X., Zhang, X.A., and Wang, D.W., The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases, Adv. Drug Delivery Rev., 2011, vol. 63, no. 8, pp. 597–609. https://doi.org/10.1016/j.addr.2011.03.006

Article  CAS  Google Scholar 

Alsaad, A.M., Zordoky, B.N., Tse, M.M., and El-Kadi, A.O., Role of cytochrome P450-mediated arachidonic acid metabolites in the pathogenesis of cardiac hypertrophy, Drug Metab. Rev., 2013, vol. 45, no. 2, pp. 173–195. https://doi.org/10.3109/03602532.2012.754460

Article  CAS  PubMed  Google Scholar 

Shoieb, S.M., Dakarapu, R., Falck, J.R., and El-Kadi, A.O.S., Novel synthetic analogues of 19(S/R)-hydroxyeicosatetraenoic acid exhibit noncompetitive inhibitory effect on the activity of cytochrome P450 1A1 and 1B1, Eur. J. Drug Metab. Pharmacokinet., 2021, vol. 46, no. 5, pp. 613–624. https://doi.org/10.1007/s13318-021-00699-9