Unfer V, Kandaraki E, Pkhaladze L, Roseff S, Vazquez-Levin MH, Laganà AS et al (2024) When one size does not fit all: reconsidering PCOS etiology, diagnosis, clinical subgroups, and subgroup-specific treatments. Endocr Metabolic Sci. 14:100159

Choudhari R, Tayade S, Tiwari A, Satone P (2024) Diagnosis, management, and Associated comorbidities of Polycystic Ovary Syndrome: a narrative review. Cureus 16(4):e58733

PubMed  PubMed Central  Google Scholar 

Stein IF, Leventhal ML (1935) Amenorrhea associated with bilateral polycystic ovaries. Am J Obstet Gynecol. 29(2):181–191

Revised (2003) consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41– 7

Teede HJ, Misso ML, Costello MF, Dokras A, Laven J, Moran L et al (2018) Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertil Steril 110(3):364–379

Article  PubMed  PubMed Central  Google Scholar 

Teede HJ, Tay CT, Laven J, Dokras A, Moran LJ, Piltonen TT et al (2023) Recommendations from the 2023 International evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. Fertil Steril 120(4):767–793

Article  PubMed  Google Scholar 

de Zegher F, Ibáñez L (2024) Leader vs follower in the tango of polycystic ovary syndrome: insulin resistance vs androgen excess. Acta Obstet Gynecol Scand 103(8):1680–1681

Article  PubMed  PubMed Central  Google Scholar 

Wen X, Wang L, Bai E (2024) Metabolic characteristics of different phenotypes in reproductive-aged women with polycystic ovary syndrome. Front Endocrinol. 2024-July-23;15.

Myers SH, Russo M, Dinicola S, Forte G, Unfer V (2023) Questioning PCOS phenotypes for reclassification and tailored therapy. Trends Endocrinol Metab 34(11):694–703

Article  PubMed  CAS  Google Scholar 

Fish LS, Busby DM (1996) The delphi method. Res Methods Family Therapy 469:482

Google Scholar 

Ramezani Tehrani F, Rashidi H, Bahri Khomami M, Tohidi M, Azizi F (2014) The prevalence of metabolic disorders in various phenotypes of polycystic ovary syndrome: a community based study in Southwest of Iran. Reproductive Biology Endocrinol 12(1):89 2014/09/16;

Article  Google Scholar 

Farhadi-Azar M, Behboudi-Gandevani S, Rahmati M, Mahboobifard F, Khalili Pouya E, Ramezani Tehrani F et al (2022) The prevalence of polycystic ovary syndrome, its phenotypes and cardio-metabolic features in a Community Sample of Iranian Population: Tehran lipid and glucose study. Frontiers in Endocrinology. 2022-March-01;13.

Krentowska A, Kowalska I (2022) Metabolic syndrome and its components in different phenotypes of polycystic ovary syndrome. Diabetes Metab Res Rev 38(1):e3464

Article  PubMed  Google Scholar 

Moghetti P, Tosi F, Bonin C, Di Sarra D, Fiers T, Kaufman JM et al (2013) Divergences in insulin resistance between the different phenotypes of the polycystic ovary syndrome. J Clin Endocrinol Metab 98(4):E628–E637

Article  PubMed  CAS  Google Scholar 

Tosi F, Villani M, Migazzi M, Faccin G, Garofalo S, Fiers T et al (2021) Insulin-mediated substrate use in women with different phenotypes of PCOS: the role of androgens. J Clin Endocrinol Metab 106(9):e3414–e25

Article  PubMed  Google Scholar 

Zhao H, Zhang J, Cheng X, Nie X, He B (2023) Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment. J Ovarian Res. 16(1):9

Mumusoglu S, Yildiz BO (2020) Polycystic ovary syndrome phenotypes and prevalence: Differential impact of diagnostic criteria and clinical versus unselected population. Curr Opin Endocr Metabolic Res 2020(06/01/):12:66–71

Article  Google Scholar 

Myers SH, Montanino Oliva M, Nordio M, Unfer V (2024) PCOS phenotype focus: phenotype D under the magnifying glass. Arch Gynecol Obstet 309(6):2307–2313

Article  PubMed  Google Scholar 

Barnes R (2014) The pathogenesis of polycystic ovary syndrome: lessons from ovarian stimulation studies. J Endocrinol Investig 21(9):567–579

Article  Google Scholar 

Attia GM, Alharbi OA, Aljohani RM (2023) The impact of irregular menstruation on Health: a review of the literature. Cureus 15(11):e49146

PubMed  PubMed Central  Google Scholar 

Myers SH, Forte G, Unfer V (2024) Has the name PCOS run its course? Arch Gynecol Obstet 310(3):1761–1762

Article  PubMed  Google Scholar 

Livadas S, Yildiz BO, Mastorakos G, Gambineri A, Pignatelli D, Giorgino F et al (2024) European survey of diagnosis and management of the polycystic ovary syndrome: full report on the ESE PCOS Special Interest Group’s 2023 Questionnaire. Eur J Endocrinol 191(2):134–143

Article  PubMed  Google Scholar 

Bizuneh AD, Joham AE, Teede H, Mousa A, Earnest A, Hawley JM et al (2025) Evaluating the diagnostic accuracy of androgen measurement in polycystic ovary syndrome: a systematic review and diagnostic meta-analysis to inform evidence-based guidelines. Hum Reprod Updat 31(1):48-63

Tosi F, Bonora E, Moghetti P (2017) Insulin resistance in a large cohort of women with polycystic ovary syndrome: a comparison between euglycaemic-hyperinsulinaemic clamp and surrogate indexes. Hum Reprod 32(12):2515–2521

Article  PubMed  CAS  Google Scholar 

Barber TM, Hanson P, Weickert MO, Franks S (2019) Obesity and polycystic ovary syndrome: implications for Pathogenesis and Novel Management Strategies. Clin Med Insights Reprod Health 13:1179558119874042

Article  PubMed  PubMed Central  Google Scholar 

Unfer V, Dinicola S, Russo MAPCOS, Paradox (2023) Does Inositol Therapy find a rationale in all the different phenotypes? Int J Mol Sci. 24(7):6213

Brennan L, Teede H, Skouteris H, Linardon J, Hill B, Moran L (2017) Lifestyle and behavioral management of polycystic ovary syndrome. J Women’s Health. 26(8):836–848

Gibson-Helm M, Teede H, Dunaif A, Dokras A (2017) Delayed diagnosis and a lack of Information Associated with Dissatisfaction in Women with Polycystic Ovary Syndrome. J Clin Endocrinol Metab 102(2):604–612

PubMed  Google Scholar 

Bodepudi R, Seher S, Khan SA, Emmanuel S, Shantha Kumar V, Nerella R et al (2023) Myoinositol Versus Metformin in the treatment of polycystic ovarian syndrome: a systematic review. Cureus 15(7):e41748

PubMed  PubMed Central  Google Scholar 

Fatima K, Jamil Z, Faheem S, Adnan A, Javaid SS, Naeem H et al (2023) Effects of myo-inositol vs. metformin on hormonal and metabolic parameters in women with PCOS: a meta-analysis. Ir J Med Sci 192(6):2801–2808

Article  PubMed  CAS  Google Scholar 

Moretti C, Bonomi M, Dionese P, Federici S, Fulghesu AM, Giannelli J et al (2024) Inositols and female reproduction disorders: a consensus statement from the working group of the Club of the Italian Society of Endocrinology (SIE)-Women’s endocrinology. J Endocrinol Invest 47(9):2111–2141

Article  PubMed  Google Scholar