Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants

Submission history

Received: 21 December 2021

Accepted: 19 January 2022

Acknowledgments

We acknowledge the study participants for their generous contributions; the OHSU COVID-19 serology study team and the OHSU occupational health department for recruitment and sample acquisition; and the OHSU clinical laboratory under the direction of Dr. Donna Hansel and Xuan Qin for SARS-Co-2 testing and reporting.

Funding: This study was funded by a grant from the M.J. Murdock Charitable Trust (MEC), an unrestricted grant from the Oregon Health & Science University (OHSU) Foundation (MEC), the National Institutes of Health training grant T32HL083808 (TAB), Oregon Health & Science University Innovative IDEA grant 1018784 (FGT), and National Institutes of Health grant R01AI145835 (WBM).

Author contributions: Conceptualization: TAB, HCL, ZLL, WBM, MEC, FGT. Cohort recruitment: ZLL, DS, BW, WBM, MEC. Sample acquisition and preparation: ZLL, DXL, DS, BW, JYL, WBM, MEC. Laboratory analysis: TAB, SKM, GG. Statistical analysis and visualization: TAB, JYL. Funding acquisition: TAB, WBM, MEC, FGT. Supervision: WBM, MEC, FGT. Writing – original draft: TAB. Writing – review and editing: all authors

Competing interests: The authors declare that they have no competing interests.

Data and materials availability: All data needed to support the conclusions of the paper are available in the paper or the supplementary materials.

This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. This license does not apply to figures/photos/artwork or other content included in the article that is credited to a third party; obtain authorization from the rights holder before using such material.

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