Fibroblast Growth Factor 21 Confers Protection Against Asthma Through Inhibition of NLRP3 Inflammasome Activation

Shin, Y.H., J. Hwang, R. Kwon, S.W. Lee, M.S. Kim, J.I. Shin, and D.K. Yon. 2023. Global, regional, and national burden of allergic disorders and their risk factors in 204 countries and territories, from 1990 to 2019: A systematic analysis for the Global Burden of Disease Study 2019. Allergy 78: 2232–2254.

Article  CAS  PubMed  Google Scholar 

Russell, R.J., L.P. Boulet, C.E. Brightling, I.D. Pavord, C. Porsbjerg, D. Dorscheid, A. Sverrild. 2024. The airway epithelium: an orchestrator of inflammation, a key structural barrier and a therapeutic target in severe asthma. European Respiratory Journal 63(4):2301397. https://doi.org/10.1183/13993003.13901397-13992023

Pelaia, C., G. Pelaia, A. Maglio, C. Tinello, L. Gallelli, N. Lombardo, R. Terracciano, and A. Vatrella. 2023. Pathobiology of Type 2 Inflammation in Asthma and Nasal Polyposis. Journal of Clinical Medicine 12: 3371.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nishimura, T., Y. Nakatake, M. Konishi, and N. Itoh. 2000. Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochimica et Biophysica Acta 1492: 203–206.

Article  CAS  PubMed  Google Scholar 

Cuevas-Ramos, D., P. Almeda-Valdes, C.A. Aguilar-Salinas, G. Cuevas-Ramos, A.A. Cuevas-Sosa, and F.J. Gomez-Perez. 2009. The role of fibroblast growth factor 21 (FGF21) on energy balance, glucose and lipid metabolism. Current Diabetes Review 5: 216–220.

Article  CAS  Google Scholar 

Beenken, A., and M. Mohammadi. 2009. The FGF family: Biology, pathophysiology and therapy. Nature Reviews. Drug Discovery 8: 235–253.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tillman, E.J., and T. Rolph. 2020. FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases. Front Endocrinol (Lausanne) 11: 601290.

Article  PubMed  Google Scholar 

Liang, Y., Q. Chen, Y. Chang, J. Han, J. Yan, Z. Chen, and J. Zhou. 2024. Critical role of FGF21 in diabetic kidney disease: From energy metabolism to innate immunity. Frontiers in Immunology 15: 1333429.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li, L., H. Wang, S. Pang, L. Wang, Z. Fan, C. Ma, S. Yang, J. Banda, Q. Hui, F. Lv, et al. 2023. rhFGF-21 accelerates corneal epithelial wound healing through the attenuation of oxidative stress and inflammatory mediators in diabetic mice. Journal of Biological Chemistry 299: 105127.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang, X., Q. Wu, Y.K. Opoku, Y. Zou, D. Wang, C. Hu, and G. Ren. 2022. Fibroblast growth factor 21 attenuates the progression of hyperuricemic nephropathy through inhibiting inflammation, fibrosis and oxidative stress. Basic & Clinical Pharmacology & Toxicology 131: 474–486.

Article  CAS  Google Scholar 

Yan, F., L. Yuan, F. Yang, G. Wu, and X. Jiang. 2022. Emerging roles of fibroblast growth factor 21 in critical disease. Frontiers in Cardiovascular Medicine 9: 1053997.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu, Y., Y. Shen, S. Zhang, N. Wang, L. Luo, X. Zhu, X. Xu, W. Cong, L. Jin, and Z. Zhu. 2022. Suppression of Cutibacterium acnes-Mediated Inflammatory Reactions by Fibroblast Growth Factor 21 in Skin. International Journal of Molecular Sciences 23: 3589.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ouyang, R., X. Zhao, R. Zhang, J. Yang, S. Li, and D. Deng. 2022. FGF21 attenuates high uric acid-induced endoplasmic reticulum stress, inflammation and vascular endothelial cell dysfunction by activating Sirt1. Molecular Medicine Reports 25: 35.

Article  CAS  PubMed  Google Scholar 

Broz, P., and V.M. Dixit. 2016. Inflammasomes: Mechanism of assembly, regulation and signalling. Nature Reviews Immunology 16: 407–420.

Article  CAS  PubMed  Google Scholar 

Que, X., S. Zheng, Q. Song, H. Pei, and P. Zhang. 2024. Fantastic voyage: The journey of NLRP3 inflammasome activation. Genes Dis 11: 819–829.

Article  CAS  PubMed  Google Scholar 

Swanson, K.V., M. Deng, and J.P. Ting. 2019. The NLRP3 inflammasome: Molecular activation and regulation to therapeutics. Nature Reviews Immunology 19: 477–489.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kodi, T., R. Sankhe, A. Gopinathan, K. Nandakumar, and A. Kishore. 2024. New Insights on NLRP3 Inflammasome: Mechanisms of Activation, Inhibition, and Epigenetic Regulation. Journal of Neuroimmune Pharmacology 19: 7.

Article  PubMed  PubMed Central  Google Scholar 

Xu, S., D. Wang, L. Tan, and J. Lu. 2024. The role of NLRP3 inflammasome in type 2 inflammation related diseases. Autoimmunity 57: 2310269.

Article  PubMed  Google Scholar 

Theofani, E., M. Semitekolou, I. Morianos, K. Samitas, and G. Xanthou. 2019. Targeting NLRP3 Inflammasome Activation in Severe Asthma. Journal of Clinical Medicine 8: 1615.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sebag, S.C., O.M. Koval, J.D. Paschke, C.J. Winters, O.A. Jaffer, R. Dworski, F.S. Sutterwala, M.E. Anderson, and I.M. Grumbach. 2017. Mitochondrial CaMKII inhibition in airway epithelium protects against allergic asthma. JCI Insight 2: e88297.

Article  PubMed  PubMed Central  Google Scholar 

Rossios, C., S. Pavlidis, U. Hoda, C.H. Kuo, C. Wiegman, K. Russell, K. Sun, M.J. Loza, F. Baribaud, A.L. Durham, et al. 2018. Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma. The Journal of Allergy and Clinical Immunology 141: 560–570.

Article  CAS  PubMed  Google Scholar 

Simpson, J.L., S. Phipps, K.J. Baines, K.M. Oreo, L. Gunawardhana, and P.G. Gibson. 2014. Elevated expression of the NLRP3 inflammasome in neutrophilic asthma. European Respiratory Journal 43: 1067–1076.

Article  PubMed  Google Scholar 

Eisenbarth, S.C., O.R. Colegio, W. O’Connor, F.S. Sutterwala, and R.A. Flavell. 2008. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature 453: 1122–1126.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim, S.R., D.I. Kim, S.H. Kim, H. Lee, K.S. Lee, S.H. Cho, and Y.C. Lee. 2014. NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation. Cell Death & Disease 5: e1498.

Article  CAS  Google Scholar 

Ma, M., G. Li, M. Qi, W. Jiang, and R. Zhou. 2021. Inhibition of the Inflammasome Activity of NLRP3 Attenuates HDM-Induced Allergic Asthma. Frontiers in Immunology 12: 718779.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lunding, L.P., D.B. Skouras, C. Vock, C.A. Dinarello, and M. Wegmann. 2022. The NLRP3 inflammasome inhibitor, OLT1177((R)), ameliorates experimental allergic asthma in mice. Allergy 77: 1035–1038.

Article  CAS  PubMed  Google Scholar 

Chen, S., L. Yao, P. Huang, Q. He, H. Guan, Y. Luo, Z. Zou, S. Wei, G. Peng, J. Yan, et al. 2019. Blockade of the NLRP3/Caspase-1 Axis Ameliorates Airway Neutrophilic Inflammation in a Toluene Diisocyanate-Induced Murine Asthma Model. Toxicological Sciences 170: 462–475.

Article  CAS  PubMed  Google Scholar 

Tang, Y., Y. Zhao, Y. Guan, L. Xue, J. Guo, T. Zhao, Y. Guan, S. Tong, and C. Che. 2024. Silencing TRIM8 alleviates allergic asthma and suppressing Th2 differentiation through inhibiting NF-kappaB/NLRP3 signaling pathway. Immunology Letters 270: 106923.

Article  CAS  PubMed  Google Scholar 

Zhan, W., H. Zhang, Y. Su, and L. Yin. 2024. TRIM47 promotes HDM-induced bronchial epithelial pyroptosis by regulating NEMO ubiquitination to activate NF-kappaB/NLRP3 signaling. Cell Biology International 48: 1138–1147.

Article  CAS  PubMed  Google Scholar 

Wang, Y., D. Zhang, T. Liu, J.F. Wang, J.X. Wu, J.P. Zhao, J.W. Xu, J.T. Zhang, and L. Dong. 2021. FSTL1 aggravates OVA-induced inflammatory responses by activating the NLRP3/IL-1beta signaling pathway in mice and macrophages. Inflammation Research 70: 777–787.

Article  CAS  PubMed 

留言 (0)

沒有登入
gif