Zhu, J., K. Li, L. Yu, Y. Chen, Y. Cai, J. Jin, et al. 2021. Targeting phosphatidylinositol 3-kinase gamma (PI3Kgamma): Discovery and development of its selective inhibitors. Medicinal Research Reviews 41:1599–1621.
Article CAS PubMed Google Scholar
Nürnberg, Beer-Hammer. 2019. Function, Regulation and Biological Roles of PI3Kγ Variants. Biomolecules 9: 427.
Article PubMed PubMed Central Google Scholar
Bauer, T. M., M. R. Patel, and J. R. Infante. 2015. Targeting PI3 kinase in cancer. Pharmacology & Therapeutics 146:53–60.
Jiang, Y., W. Xiong, L. Jia, L. Xu, Y. Cai, Y. Chen, et al. 2022. Developing a Naive Bayesian Classification Model with PI3Kgamma structural features for virtual screening against PI3Kgamma: Combining molecular docking and pharmacophore based on multiple PI3Kgamma conformations. European Journal of Medicinal Chemistry 244:114824.
Article CAS PubMed Google Scholar
Jia, L., L. Wang, Y. Jiang, L. Xu, Y. Cai, Y. Chen, et al. 2022. Exploring PI3Kgamma binding preference with Eganelisib, Duvelisib, and Idelalisib via energetic, pharmacophore and dissociation pathway analyses. Computers in Biology and Medicine 147:105642.
Article CAS PubMed Google Scholar
Jingyu, Zhu, Hou Tingjun, and Mao Xinliang. 2015. Discovery of selective phosphatidylinositol 3-kinase inhibitors to treat hematological malignancies. Drug Discovery Today 20:988–994.
Cushing, T. D., D. P. Metz, et al. 2012. PI3Kδ and PI3Kγ as Targets for Autoimmune and Inflammatory Diseases. Journal of Medicinal Chemistry 55:8559–8581.
Article CAS PubMed Google Scholar
Xiong, W. D., L. Jia, Y. F. Cai, Y. Chen, J. Jin, and J. Y. Zhu. 2023. Investigation Into The Anti-inflammation and PI3K? Inhibitory Preference of Eganelisib. Progress in Biochemistry and Biophysics 50:1971–1981.
Williams, O., B. Houseman, T. Kunkel, et al. 2010. Discovery of dual inhibitors of the immune cell PI3Ks p110d and p110g: a prototype for new anti-inflammatory drugs. Chemistry & Biology 17:123–134.
Lanahan, S. M., M. P. Wymann, and C. L. Lucas. 2022. The role of PI3Kgamma in the immune system: New insights and translational implications. Nature Reviews Immunology 22:687–700.
Article CAS PubMed PubMed Central Google Scholar
Henau, O. D., M. Rausch, D. Winkler, L. F. Campesato, C. Liu, D. H. Cymerman, et al. 2016. Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells. Nature 539:443–447.
Article PubMed PubMed Central Google Scholar
Kaneda, M. M., K. S. Messer, N. Ralainirina, H. Li, C. J. Leem, S. Gorjestani, et al. 2016. PI3Kγ is a molecular switch that controls immune suppression. Nature 539:437–442.
Article CAS PubMed PubMed Central Google Scholar
Cirillo, D., M. Diceglie, and M. Nazaré. 2023. Isoform-selective targeting of PI3K: Time to consider new opportunities? Trends in Pharmacological Sciences 44:601–621.
Article CAS PubMed Google Scholar
Papi, A., C. Brightling, S.E. Pedersen, and H.K. Reddel. 2018. Asthma. The Lancet 391:783–800.
Akar-Ghibril, N., T. Casale, A. Custovic, and W. Phipatanakul. 2020. Allergic Endotypes and Phenotypes of Asthma. The Journal of Allergy and Clinical Immunology: In Practice 8:429–440.
Gandhi, N. A., B. L. Bennett, N. Graham, G. Pirozzi, N. Stahl, and G. D. Yancopoulos. 2016. Targeting key proximal drivers of type 2 inflammation in disease. Nature Reviews. Drug Discovery 15:35–50.
Article CAS PubMed Google Scholar
Barberis, L., and E. Hirsch. 2008. Targeting phosphoinositide 3-kinase gamma to fight inflammation and more. Thrombosis and Haemostasis 99:279–285.
Article CAS PubMed Google Scholar
Ghigo, A., F. Damilano, L. Braccini, and E. Hirsch. 2010. PI3K inhibition in inflammation: Toward tailored therapies for specific diseases. BioEssays 32:185–196.
Article CAS PubMed Google Scholar
Xiong, W., L. Jia, J. Liang, Y. Cai, Y. Chen, Y. Nie, et al. 2022. Investigation into the anti-airway inflammatory role of the PI3Kgamma inhibitor JN-PK1: An in vitro and in vivo study. International Immunopharmacology 111:109102.
Article CAS PubMed Google Scholar
Campa, C. C., R. L. Silva, J. P. Margaria, T. Pirali, M. S. Mattos, L. R. Kraemer, et al. 2018. Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis. Nature Communications 9:5232.
Article CAS PubMed PubMed Central Google Scholar
Xu, C. Y., S. Y. Chen, Y. Deng, J. F. Song, J. H. Li, X. Chen, et al. 2021. Distinct roles of PI3Kδ and PI3Kγ in a toluene diisocyanate-induced murine asthma model. Toxicology 454:152747.
Article CAS PubMed Google Scholar
Saito, Y., M. Takeda, J. Nishikawa, Y. Konno, M. Tamaki, M. Itoga, et al. 2014. The effect of pharmacological PI3Kγ inhibitor on eotaxin-induced human eosinophil functions. Pulmonary Pharmacology & Therapeutics 27:164–169.
Xiong, W., L. Jia, Y. Cai, Y. Chen, M. Gao, J. Jin, et al. 2023. Evaluation of the anti-inflammatory effects of PI3Kδ/γ inhibitors for treating acute lung injury. Immunobiology 228:152753.
Article CAS PubMed Google Scholar
Zhu, J. Y., D. Sun, X. T. Li, L. Jia, Y. F. Cai, Y. Chen, et al. 2023. Developing new PI3Kγ inhibitors by combining pharmacophore modeling, molecular dynamic simulation, molecular docking, fragment-based drug design, and virtual screening. Computational Biology and Chemistry 104:107879.
Article CAS PubMed Google Scholar
Zhu, J., K. Li, L. Xu, Y. Cai, Y. Chen, X. Zhao, et al. 2022. Discovery of novel selective PI3Kgamma inhibitors through combining machine learning-based virtual screening with multiple protein structures and bio-evaluation. Journal of Advanced Research 36:1–13.
Xue, L., C. Li, G. Ge, S. Zhang, L. Tian, Y. Wang, et al. 2021. Jia-Wei-Yu-Ping-Feng-San Attenuates Group 2 Innate Lymphoid Cell-Mediated Airway Inflammation in Allergic Asthma. Frontiers in Pharmacology 12:703724.
Article CAS PubMed PubMed Central Google Scholar
Dong, L., Y. Wang, T. Zheng, Y. Pu, Y. Ma, X. Qi, et al. 2021. Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice. Stem Cell Research & Therapy 12:4.
Liang, X., M. Deng, F. Zou, Z. Qi, C. Wang, J. Liu, et al. 2023. Discovery of Pyrazolo[1,5-a]pyrimidine derivative as a potent and selective PI3Kγ/δ dual inhibitor. European Journal of Medicinal Chemistry 260:115768.
Article CAS PubMed Google Scholar
Schneble, N., C. Schmidt, R. Bauer, J. P. Müller, S. Monajembashi, and R. Wetzker. 2017. Phosphoinositide 3-kinase γ ties chemoattractant- and adrenergic control of microglial motility. Molecular and Cellular Neuroscience 78:1–8.
Article CAS PubMed Google Scholar
Orecchioni, M., Y. Ghosheh, A.B. Pramod, and K. Ley. 2019. Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated Macrophages. Front Immunol 10:1084.
Article CAS PubMed PubMed Central Google Scholar
Zhu, L., Q. Zhao, T. Yang, W. Ding, and Y. Zhao. 2015. Cellular metabolism and macrophage functional polarization. International Reviews of Immunology 34:82–100.
Peace, C. G., and L. A. O’Neill. 2022. The role of itaconate in host defense and inflammation. The Journal of Clinical Investigation 132:e148548.
留言 (0)