Exosomes Derived from Endoplasmic Reticulum Stressed Hepatocellular Carcinoma Cells Enhance the Antitumor Immunity of Dendritic Cells

El-Serag, H.B. 2012. Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology 142 (1264–1273): e1.

Google Scholar 

Garg, A.D., D.V. Krysko, P. Vandenabeele, and P. Agostinis. 2012. The emergence of phox-ER stress induced immunogenic apoptosis. Oncoimmunology 1: 786–788.

Article  PubMed  PubMed Central  Google Scholar 

Peters, M., S. Wellek, H.P. Dienes, T. Junginger, J. Meyer, K.H. Meyer Zum Buschendfelde, et al. 1994. Epidemiology of hepatocellular carcinoma. Evaluation of viral and other risk factors in a low-endemic area for hepatitis B and C. Zeitschrift fur Gastroenterologie 32: 146–151.

PubMed  Google Scholar 

Miller, J.F., and M. Sadelain. 2015. The journey from discoveries in fundamental immunology to cancer immunotherapy. Cancer Cell 27: 439–449.

Article  PubMed  Google Scholar 

Yu, L.Y., J. Tang, C.M. Zhang, W.J. Zeng, H. Yan, M.P. Li, et al. 2017. New immunotherapy strategies in breast cancer. International journal of environmental research and public health 14: 14.

Article  Google Scholar 

Moris, D., E.W. Beal, J. Chakedis, R.A. Burkhart, C. Schmidt, M. Dillhoff, et al. 2017. Role of exosomes in treatment of hepatocellular carcinoma. Surgical oncology 26: 219–228.

Article  PubMed  Google Scholar 

Palmer, D.H., R.S. Midgley, N. Mirza, E.E. Torr, F. Ahmed, J.C. Steele, et al. 2009. A phase II study of adoptive immunotherapy using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinoma. Hepatology 49: 124–132.

Article  PubMed  Google Scholar 

Butterfield, L.H., A. Ribas, V.B. Dissette, Y. Lee, J.Q. Yang, P. De la Rocha, et al. 2006. A phase I/II trial testing immunization of hepatocellular carcinoma patients with dendritic cells pulsed with four alpha-fetoprotein peptides. Clinical cancer research : An official journal of the American Association for Cancer Research 12: 2817–2825.

Article  PubMed  Google Scholar 

Zeng, Y., H. Feng, M.W. Graner, and E. Katsanis. 2003. Tumor-derived, chaperone-rich cell lysate activates dendritic cells and elicits potent antitumor immunity. Blood 101: 4485–4491.

Article  PubMed  Google Scholar 

Pusztai, L., T. Karn, A. Safonov, M.M. Abu-Khalaf, and G. Bianchini. 2016. New strategies in breast cancer: Immunotherapy. Clinical cancer research : An official journal of the American Association for Cancer Research 22: 2105–2110.

Article  PubMed  Google Scholar 

Ma, Y., G.V. Shurin, D.W. Gutkin, and M.R. Shurin. 2012. Tumor associated regulatory dendritic cells. Seminars in cancer biology 22: 298–306.

Article  PubMed  PubMed Central  Google Scholar 

Ueno, H., E. Klechevsky, R. Morita, C. Aspord, T. Cao, T. Matsui, et al. 2007. Dendritic cell subsets in health and disease. Immunological eviews 219: 118–142.

Google Scholar 

Osorio, F., C. Fuentes, M.N. Lopez, F. Salazar-Onfray, and F.E. Gonzalez. 2015. Role of dendritic cells in the induction of lymphocyte tolerance. Frontiers in mmunology 6: 535.

Google Scholar 

Fan, L., G. Sun, T. Ma, F. Zhong, Y. Lei, X. Li, et al. 2013. Melatonin reverses tunicamycin-induced endoplasmic reticulum stress in human hepatocellular carcinoma cells and improves cytotoxic response to doxorubicin by increasing CHOP and decreasing survivin. Journal of ineal research 55: 184–194.

Google Scholar 

Graner, M.W., K.O. Lillehei, and E. Katsanis. 2014. Endoplasmic reticulum chaperones and their roles in the immunogenicity of cancer vaccines. Frontiers in ncology 4: 379.

Google Scholar 

Chen, W., J. Wang, C. Shao, S. Liu, Y. Yu, Q. Wang, et al. 2006. Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells. European ournal of immunology 36: 1598–1607.

Article  Google Scholar 

Lee, B.R., S.Y. Chang, E.H. Hong, B.E. Kwon, H.M. Kim, Y.J. Kim, et al. 2014. Elevated endoplasmic reticulum stress reinforced immunosuppression in the tumor microenvironment via myeloid-derived suppressor cells. Oncotarget 5: 12331–12345.

Article  PubMed  PubMed Central  Google Scholar 

Montico B, Nigro A, Casolaro V, Dal Col J. 2018. Immunogenic apoptosis as a novel tool for anticancer vaccine development. International Journal of Molecular Sciences 19 (2): 594.

Hodge, J.W., C.T. Garnett, B. Farsaci, C. Palena, K.Y. Tsang, S. Ferrone, et al. 2013. Chemotherapy-induced immunogenic modulation of tumor cells enhances killing by cytotoxic T lymphocytes and is distinct from immunogenic cell death. International ournal of cancer 133: 624–636.

Article  Google Scholar 

Lv, L.H., Y.L. Wan, Y. Lin, W. Zhang, M. Yang, G.L. Li, et al. 2012. Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell antitumor responses in vitro. The Journal of Biological chemistry 287: 15874–15885.

Article  PubMed  PubMed Central  Google Scholar 

van der Pol, E., A.N. Boing, P. Harrison, A. Sturk, and R. Nieuwland. 2012. Classification, functions, and clinical relevance of extracellular vesicles. Pharmacological eviews 64: 676–705.

Google Scholar 

Rao, Q., B. Zuo, Z. Lu, X. Gao, A. You, C. Wu, et al. 2016. Tumor-derived exosomes elicit tumor suppression in murine hepatocellular carcinoma models and humans in vitro. Hepatology 64: 456–472.

Article  PubMed  Google Scholar 

Wolfers, J., A. Lozier, G. Raposo, A. Regnault, C. Thery, C. Masurier, et al. 2001. Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nature medicine 7: 297–303.

Article  PubMed  Google Scholar 

Dai, S., X. Zhou, B. Wang, Q. Wang, Y. Fu, T. Chen, et al. 2006. Enhanced induction of dendritic cell maturation and HLA-A*0201-restricted CEA-specific CD8(+) CTL response by exosomes derived from IL-18 gene-modified CEA-positive tumor cells. Journal of Molecular Medicine 84: 1067–1076.

Article  PubMed  Google Scholar 

Liu, J., L. Fan, H. Yu, J. Zhang, Y. He, D. Feng, et al. 2019. Endoplasmic reticulum stress causes liver cancer cells to release exosomal miR-23a-3p and up-regulate programmed death ligand 1 expression in macrophages. Hepatology 70: 241–258.

Article  PubMed  Google Scholar 

Li, R., F. Fang, M. Jiang, C. Wang, J. Ma, W. Kang, et al. 2017. STAT3 and NF-kappaB are simultaneously suppressed in dendritic cells in lung cancer. Scientific Reports 7: 45395.

Article  PubMed  PubMed Central  Google Scholar 

Blom, K.G., M.R. Qazi, J.B. Matos, B.D. Nelson, J.W. DePierre, and M. Abedi-Valugerdi. 2009. Isolation of murine intrahepatic immune cells employing a modified procedure for mechanical disruption and functional characterization of the B, T and natural killer T cells obtained. Clinical and Experimental mmunology 155: 320–329.

Article  Google Scholar 

Adamowicz, J., T. Kloskowski, J. Tworkiewicz, M. Pokrywczynska, and T. Drewa. 2012. Urine is a highly cytotoxic agent: Does it influence stem cell therapies in urology? Transplantation roceedings 44: 1439–1441.

Article  Google Scholar 

Wang, L., Y. Huang, X. Wang, and Y. Chen. 2019. Label-Free LC-MS/MS proteomics analyses reveal proteomic changes accompanying MSTN KO in C2C12 Cells. BioMed Research International 2019: 7052456.

PubMed  PubMed Central  Google Scholar 

Langenkamp, A., M. Messi, A. Lanzavecchia, and F. Sallusto. 2000. Kinetics of dendritic cell activation: Impact on priming of TH1, TH2 and nonpolarized T cells. Nature mmunology 1: 311–316.

Google Scholar 

Felzmann, T., K.G. Huttner, S.K. Breuer, D. Wimmer, G. Ressmann, D. Wagner, et al. 2005. Semi-mature IL-12 secreting dendritic cells present exogenous antigen to trigger cytolytic immune responses. Cancer Immunology, mmunotherapy : CII 54: 769–780.

Article  Google Scholar 

Fucikova, J., P. Kralikova, A. Fialova, T. Brtnicky, L. Rob, J. Bartunkova, et al. 2011. Human tumor cells killed by anthracyclines induce a tumor-specific immune response. Cancer esearch 71: 4821–4833.

Article  Google Scholar 

Clarke, H.J., J.E. Chambers, E. Liniker, and S.J. Marciniak. 2014. Endoplasmic reticulum stress in malignancy. Cancer Cell 25: 563–573.

Article  PubMed  Google Scholar 

Brewer, J.W., and J.A. Diehl. 2000. PERK mediates cell-cycle exit during the mammalian unfolded protein response. Proceedings of the National Academy of Sciences of the United States of America 97: 12625–12630.

Article  PubMed  PubMed Central  Google Scholar 

Andre, F., N.E. Schartz, M. Movassagh, C. Flament, P. Pautier, P. Morice, et al. 2002. Malignant effusions and immunogenic tumour-derived exosomes. Lancet 360: 295–305.

Article  PubMed  Google Scholar 

Hickman-Miller, H.D., and W.H. Hildebrand. 2004. The immune response under stress: The role of HSP-derived peptides. Trends in mmunology 25: 427–433.

Article  Google Scholar 

Spisek, R., A. Charalambous, A. Mazumder, D.H. Vesole, S. Jagannath, and M.V. Dhodapkar. 2007. Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: Therapeutic implications. Blood 109: 4839–4845.

Article  PubMed  PubMed Central  Google Scholar 

Rakoff-Nahoum, S., and R. Medzhitov. 2009. Toll-like receptors and cancer. Nature Reviews ancer 9: 57–63.

Article  Google Scholar 

Zitvogel, L., O. Kepp, and G. Kroemer. 2011. Immune parameters affecting the efficacy of chemotherapeutic regimens. Nature Reviews Clinical Oncology 8: 151–160.

Article  PubMed 

留言 (0)

沒有登入
gif