Inhibition of Mitochondrial Succinate Dehydrogenase with Dimethyl Malonate Promotes M2 Macrophage Polarization by Enhancing STAT6 Activation

Murray, P.J. 2017. Macrophage polarization. Annual Review of Physiology 79: 541–566.

Article  CAS  PubMed  Google Scholar 

Motwani, M.P., and D.W. Gilroy. 2015. Macrophage development and polarization in chronic inflammation. Seminars in Immunology 27: 257–266.

Article  PubMed  Google Scholar 

Cao, M., Z. Wu, Q. Lou, W. Lu, J. Zhang, Q. Li, et al. 2019. Dectin-1-induced RIPK1 and RIPK3 activation protects host against candida albicans infection. Cell Death and Differentiation 26: 2622–2636.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu, Y.C., X.B. Zou, Y.F. Chai, and Y.M. Yao. 2014. Macrophage polarization in inflammatory diseases. International Journal of Biological Sciences 10: 520–529.

Article  PubMed  PubMed Central  Google Scholar 

Szanto, A., B.L. Balint, Z.S. Nagy, E. Barta, B. Dezso, A. Pap, et al. 2010. STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells. Immunity 33: 699–712.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Girodet, P.O., D. Nguyen, J.D. Mancini, M. Hundal, X. Zhou, E. Israel, et al. 2016. Alternative macrophage activation is increased in asthma. American Journal of Respiratory Cell and Molecular Biology 55: 467–475.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wynn, T.A., and K.M. Vannella. 2016. Macrophages in tissue repair, regeneration, and fibrosis. Immunity 44: 450–462.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abdelaziz, M.H., S.F. Abdelwahab, J. Wan, W. Cai, W. Huixuan, C. Jianjun, et al. 2020. Alternatively activated macrophages; a double-edged sword in allergic asthma. Journal of Translational Medicine 18: 58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee, Y.G., J.J. Jeong, S. Nyenhuis, E. Berdyshev, S. Chung, R. Ranjan, et al. 2015. Recruited alveolar macrophages, in response to airway epithelial-derived monocyte chemoattractant protein 1/CCl2, regulate airway inflammation and remodeling in allergic asthma. American Journal of Respiratory Cell and Molecular Biology 52: 772–784.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zasłona, Z., S. Przybranowski, C. Wilke, N. van Rooijen, S. Teitz-Tennenbaum, J.J. Osterholzer, et al. 2014. Resident alveolar macrophages suppress, whereas recruited monocytes promote, allergic lung inflammation in murine models of asthma. The Journal of Immunology 193: 4245–4253.

Article  PubMed  Google Scholar 

Italiani, P., and D. Boraschi. 2014. From monocytes to M1/M2 macrophages: Phenotypical vs. Functional Differentiation. Front Immunol 5: 514.

PubMed  Google Scholar 

Galván-Peña, S., and L.A. O’Neill. 2014. Metabolic reprograming in macrophage polarization. Frontiers in Immunology 5: 420.

PubMed  PubMed Central  Google Scholar 

Ryan, D.G., M.P. Murphy, C. Frezza, H.A. Prag, E.T. Chouchani, L.A. O’Neill, et al. 2019. Coupling Krebs cycle metabolites to signalling in immunity and cancer. Nature Metabolism 1: 16–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

O’Neill, L.A., R.J. Kishton, and J. Rathmell. 2016. A guide to immunometabolism for immunologists. Nature Reviews Immunology 16: 553–565.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mills, E.L., B. Kelly, A. Logan, A.S.H. Costa, M. Varma, C.E. Bryant, et al. 2016. Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages. Cell 167: 457-470.e13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tannahill, G.M., A.M. Curtis, J. Adamik, E.M. Palsson-McDermott, A.F. McGettrick, G. Goel, et al. 2013. Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature 496: 238–242.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rubic, T., G. Lametschwandtner, S. Jost, S. Hinteregger, J. Kund, N. Carballido-Perrig, et al. 2008. Triggering the succinate receptor GPR91 on dendritic cells enhances immunity. Nature Immunology 9: 1261–1269.

Article  CAS  PubMed  Google Scholar 

O’Neill, L.A.J., and M.N. Artyomov. 2019. Itaconate: The poster child of metabolic reprogramming in macrophage function. Nature Reviews Immunology 19: 273–281.

Article  CAS  PubMed  Google Scholar 

Murphy, M.P., and L.A.J. O’Neill. 2018. Krebs cycle reimagined: The emerging roles of succinate and itaconate as signal transducers. Cell 174: 780–784.

Article  CAS  PubMed  Google Scholar 

Peace, C.G., and L.A. O’Neill. 2022. The role of itaconate in host defense and inflammation. Journal of Clinical Investigation 132: e148548.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ryan, D.G., and L.A.J. O’Neill. 2020. Krebs Cycle Reborn in Macrophage Immunometabolism. Annual Review of Immunology 38: 289–313.

Article  CAS  PubMed  Google Scholar 

Lampropoulou, V., A. Sergushichev, M. Bambouskova, S. Nair, E.E. Vincent, E. Loginicheva, et al. 2016. Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation. Cell Metabolism 24: 158–166.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, F., W.A.M. Elgaher, M. Winterhoff, K. Büssow, F.H. Waqas, E. Graner, et al. 2022. Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism. Nature Metabolism 4: 534–546.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hooftman, A., C.G. Peace, D.G. Ryan, E.A. Day, M. Yang, A.F. McGettrick, et al. 2023. Macrophage fumarate hydratase restrains mtRNA-mediated interferon production. Nature 615: 490–498.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zecchini, V., V. Paupe, I. Herranz-Montoya, J. Janssen, I.M.N. Wortel, J.L. Morris, et al. 2023. Fumarate induces vesicular release of mtDNA to drive innate immunity. Nature 615: 499–506.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Humphries, F., L. Shmuel-Galia, N. Ketelut-Carneiro, S. Li, B. Wang, V.V. Nemmara, et al. 2020. Succination inactivates gasdermin D and blocks pyroptosis. Science 369: 1633–1637.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, Y., N. Li, X. Zhang, and T. Horng. 2021. Mitochondrial metabolism regulates macrophage biology. Journal of Biological Chemistry 297: 100904.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sharma, P., R. Chakraborty, L. Wang, B. Min, M.L. Tremblay, T. Kawahara, et al. 2008. Redox regulation of interleukin-4 signaling. Immunity 29: 551–564.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu, J.Y., T.W. Huang, Y.T. Hsieh, Y.F. Wang, C.C. Yen, G.L. Lee, et al. 2020. Cancer-derived succinate promotes macrophage polarization and cancer metastasis via succinate receptor. Molecular Cell 77: 213-227.e5.

Article  CAS  PubMed 

留言 (0)

沒有登入
gif