Neurotensin-neurotensin receptor 2 signaling in adipocytes suppresses food intake through regulating ceramide metabolism

Halaas, J. L. et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269, 543–546 (1995).

Article  CAS  PubMed  Google Scholar 

Kershaw, E. E. & Flier, J. S. Adipose tissue as an endocrine organ. J. Clin. Endocrinol. Metab. 89, 2548–2556 (2004).

Article  CAS  PubMed  Google Scholar 

Kong, X. et al. Brown adipose tissue controls skeletal muscle function via the secretion of myostatin. Cell Metab. 28, 631–643.e3 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin, Y. et al. The chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte/IL-33/type 2 innate immunity circuit. Sci. Immunol. 6, eabg9698 (2021).

Article  CAS  PubMed  Google Scholar 

Checler, F., Barelli, H., Kitabgi, P. & Vincent, J. P. Neurotensin metabolism in various tissues of central and peripheral origins: ubiquitous involvement of a novel neurotensin degrading metalloendopeptidase. Biochimie 70, 75–82 (1988).

Article  CAS  PubMed  Google Scholar 

Checler, F., Mazella, J., Kitabgi, P. & Vincent, J. P. High-affinity receptor sites and rapid proteolytic inactivation of neurotensin in primary cultured neurons. J. Neurochem. 47, 1742–1748 (1986).

Article  CAS  PubMed  Google Scholar 

Tschumi, C. W. & Beckstead, M. J. Diverse actions of the modulatory peptide neurotensin on central synaptic transmission. Eur. J. Neurosci. 49, 784–793 (2019).

Article  PubMed  Google Scholar 

Kurt, G. et al. Time to drink: Activating lateral hypothalamic area neurotensin neurons promotes intake of fluid over food in a time-dependent manner. Physiol. Behav. 247, 113707 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Evers, B. M. et al. Characterization of promoter elements required for cell-specific expression of the neurotensin/neuromedin N gene in a human endocrine cell line. Mol. Cell. Biol. 15, 3870–3881 (1995).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hwang, J. I., Kim, D. K., Kwon, H. B., Vaudry, H. & Seong, J. Y. Phylogenetic history, pharmacological features, and signal transduction of neurotensin receptors in vertebrates. Ann. N. Y. Acad. Sci. 1163, 169–178 (2009).

Article  CAS  PubMed  Google Scholar 

Geisler, S., Berod, A., Zahm, D. S. & Rostene, W. Brain neurotensin, psychostimulants, and stress–emphasis on neuroanatomical substrates. Peptides 27, 2364–2384 (2006).

Article  CAS  PubMed  Google Scholar 

Leckstrom, A., Kim, E. R., Wong, D. & Mizuno, T. M. Xenin, a gastrointestinal peptide, regulates feeding independent of the melanocortin signaling pathway. Diabetes 58, 87–94 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cooke, J. H. et al. Peripheral and central administration of xenin and neurotensin suppress food intake in rodents. Obesity 17, 1135–1143 (2009).

Article  CAS  PubMed  Google Scholar 

Mazella, J. et al. The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor. J. Biol. Chem. 273, 26273–26276 (1998).

Article  CAS  PubMed  Google Scholar 

Kim, J. T. et al. Neurotensin receptor 3/Sortilin contributes to tumorigenesis of neuroendocrine tumors through augmentation of cell adhesion and migration. Neoplasia 20, 175–181 (2018).

Article  CAS  PubMed  Google Scholar 

Devader, C. et al. Increased brain neurotensin and NTSR2 lead to weak nociception in NTSR3/Sortilin knockout mice. Front. Neurosci. 10, 542 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Ratner, C. et al. Effects of peripheral neurotensin on appetite regulation and its role in gastric bypass surgery. Endocrinology 157, 3482–3492 (2016).

Article  CAS  PubMed  Google Scholar 

Levine, A. S., Kneip, J., Grace, M. & Morley, J. E. Effect of centrally administered neurotensin on multiple feeding paradigms. Pharmacol. Biochem. Behav. 18, 19–23 (1983).

Article  CAS  PubMed  Google Scholar 

Woodworth, H. L. et al. Lateral hypothalamic neurotensin neurons orchestrate dual weight loss behaviors via distinct mechanisms. Cell Rep. 21, 3116–3128 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim, E. R., Leckstrom, A. & Mizuno, T. M. Impaired anorectic effect of leptin in neurotensin receptor 1-deficient mice. Behav. Brain Res. 194, 66–71 (2008).

Article  CAS  PubMed  Google Scholar 

Remaury, A. et al. Targeted inactivation of the neurotensin type 1 receptor reveals its role in body temperature control and feeding behavior but not in analgesia. Brain Res. 953, 63–72 (2002).

Article  CAS  PubMed  Google Scholar 

Ramirez-Virella, J. & Leinninger, G. M. The role of central neurotensin in regulating feeding and body weight. Endocrinology 162, bqab038 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Li, J. et al. Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells. Cell Metab. 33, 1449–1465.e6 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu, C., Yi, C., Fu, W., Xiong, X. & Li, J. Metabolitin regulates intestinal fat absorption via lymphatic endothelial cells derived neurotensin. J. Hepatol. 79, e37–e39 (2023).

Article  CAS  PubMed  Google Scholar 

Liu, C. X. X. & Li, Jin Regulation of atherosclerosis development by neurotensin derived from lymphatic endothelial cells in mice. Arterioscler. Thromb. Vasc. Biol. 43, 1743–1745 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu, C. & Li, J. The physiological functions of lymphangiocrine signals. Trends Endocrinol. Metab. 34, 319–320 (2023).

Article  CAS  PubMed  Google Scholar 

Roh, H. C. et al. Simultaneous transcriptional and epigenomic profiling from specific cell types within heterogeneous tissues in vivo. Cell Rep. 18, 1048–1061 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi, R. H., Tatum, S. M., Symons, J. D., Summers, S. A. & Holland, W. L. Ceramides and other sphingolipids as drivers of cardiovascular disease. Nat. Rev. Cardiol. 18, 701–711 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sassa, T., Hirayama, T. & Kihara, A. Enzyme activities of the ceramide synthases CERS2-6 are regulated by phosphorylation in the c-terminal region. J. Biol. Chem. 291, 7477–7487 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Laviad, E. L. et al. Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate. J. Biol. Chem. 283, 5677–5684 (2008).

Article  CAS  PubMed 

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