Montero M, Yon L, Kikuyama S, Dufour S, Vaudry H. Molecular evolution of the growth hormone-releasing hormone/pituitary adenylate cyclase-activating polypeptide gene family. Functional implication in the regulation of growth hormone secretion. J Mol Endocrinol. 2000;25(2):157–68. https://doi.org/10.1677/jme.0.0250157
Giustina A, Veldhuis JD. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev. 1998;19(6):717–97. https://doi.org/10.1210/edrv.19.6.0353.
Article CAS PubMed Google Scholar
Bennett R. Growth hormone in musculoskeletal pain states. Curr Pain Headache Rep. 2005;9(5):331–8. https://doi.org/10.1007/s11916-005-0009-4.
Kiaris H, Schally AV, Kalofoutis A. Extrapituitary effects of the growth hormone-releasing hormone. Vitam Horm. 2005;70:1–24. https://doi.org/10.1016/s0083-6729(05)70001-7.
Article CAS PubMed Google Scholar
Barabutis N, Schally AV. Growth hormone-releasing hormone: extrapituitary effects in physiology and pathology. Cell Cycle. 2010;9(20):4110–6. https://doi.org/10.4161/cc.9.20.13787.
Article CAS PubMed Google Scholar
Granata R. Peripheral activities of growth hormone-releasing hormone. J Endocrinol Invest. 2016;39(7):721–7. https://doi.org/10.1007/s40618-016-0440-x.
Article CAS PubMed Google Scholar
Koskenniemi JJ, Virtanen HE, Wohlfahrt-Veje C, Löyttyniemi E, Skakkebaek NE, Juul A, Andersson AM, Main KM, Toppari J. Postnatal Changes in Testicular Position Are Associated With IGF-I and Function of Sertoli and Leydig Cells. J Clin Endocrinol Metab. 2018;103(4):1429–37. https://doi.org/10.1210/jc.2017-01889.
Henricks DM, Kouba AJ, Lackey BR, Boone WR, Gray SL. Identification of insulin-like growth factor I in bovine seminal plasma and its receptor on spermatozoa: influence on sperm motility. Biol Reprod. 1998;59(2):330–7. https://doi.org/10.1095/biolreprod59.2.330.
Article CAS PubMed Google Scholar
Asimakopoulos B, Tiptiri-Kourpeti A, Metallinou C. IGF-I and NGFβ enhance in vitro progressive motility and vitality of human spermatozoa. Reprod Med Biol. 2021;20(3):361–7. https://doi.org/10.1002/rmb2.12393.
Article CAS PubMed PubMed Central Google Scholar
Baumgarten SC, Armouti M, Ko C, Stocco C. IGF1R Expression in Ovarian Granulosa Cells Is Essential for Steroidogenesis, Follicle Survival, and Fertility in Female Mice. Endocrinology. 2017;158(7):2309–18. https://doi.org/10.1210/en.2017-00146.
Article CAS PubMed PubMed Central Google Scholar
Zhou P, Baumgarten SC, Wu Y, Bennett J, Winston N, Hirshfeld-Cytron J, Stocco C. IGF-I signaling is essential for FSH stimulation of AKT and steroidogenic genes in granulosa cells. Mol Endocrinol. 2013;27(3):511–23. https://doi.org/10.1210/me.2012-1307.
Article CAS PubMed PubMed Central Google Scholar
Neirijnck Y, Papaioannou MD, Nef S. The Insulin/IGF System in Mammalian Sexual Development and Reproduction. Int J Mol Sci. 2019;20(18). https://doi.org/10.3390/ijms20184440
Tenuta M, Carlomagno F, Cangiano B, Kanakis G, Pozza C, Sbardella E, Isidori AM, Krausz C, Gianfrilli D. Somatotropic-Testicular Axis: A crosstalk between GH/IGF-I and gonadal hormones during development, transition, and adult age. Andrology. 2021;9(1):168–84. https://doi.org/10.1111/andr.12918.
Article CAS PubMed Google Scholar
Metallinou C, Staneloudi C, Nikolettos K, Asimakopoulos B. NGF, EPO, and IGF-1 in the Male Reproductive System. J Clin Med. 2024;13(10). https://doi.org/10.3390/jcm13102918
Ghasemian Nafchi H, Azizi Y, Halvaei I. The role of growth factors in human sperm parameters: A review of in vitro studies. Int J Reprod Biomed. 2022;20(10):807–818. https://doi.org/10.18502/ijrm.v20i10.12265
Han L, Tian H, Guo X, Zhang L. Regulation of ovarian function by growth hormone: Potential intervention of ovarian aging. Front Endocrinol (Lausanne). 2022;13:1072313. https://doi.org/10.3389/fendo.2022.1072313.
Devesa J, Caicedo D. The Role of Growth Hormone on Ovarian Functioning and Ovarian Angiogenesis. Front Endocrinol (Lausanne). 2019;10:450. https://doi.org/10.3389/fendo.2019.00450.
Lucy MC. Growth hormone regulation of follicular growth. Reprod Fertil Dev. 2011;24(1):19–28. https://doi.org/10.1071/rd11903.
Article CAS PubMed Google Scholar
Arvat E, Gianotti L, Giordano R, Broglio F, Maccario M, Lanfranco F, Muccioli G, Papotti M, Graziani A, Ghigo E, Deghenghi R. Growth hormone-releasing hormone and growth hormone secretagogue-receptor ligands: focus on reproductive system. Endocrine. 2001;14(1):35–43. https://doi.org/10.1385/endo:14:1:035.
Article CAS PubMed Google Scholar
Chhabra Y, Waters MJ, Brooks AJ. Role of the growth hormone-IGF-1 axis in cancer. Expert Rev Endocrinol Metab. 2011;6(1):71–84. https://doi.org/10.1586/eem.10.73.
Article CAS PubMed Google Scholar
Basu R, Kopchick JJ. GH and IGF1 in cancer therapy resistance. Endocr Relat Cancer. 2023;30(9). https://doi.org/10.1530/erc-22-0414
Rekasi Z, Varga JL, Schally AV, Halmos G, Armatis P, Groot K, Czompoly T. Antagonists of growth hormone-releasing hormone and vasoactive intestinal peptide inhibit tumor proliferation by different mechanisms: evidence from in vitro studies on human prostatic and pancreatic cancers. Endocrinology. 2000;141(6):2120–8. https://doi.org/10.1210/endo.141.6.7511.
Article CAS PubMed Google Scholar
Rekasi Z, Czompoly T, Schally AV, Halmos G. Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancers. Proc Natl Acad Sci U S A. 2000;97(19):10561–6. https://doi.org/10.1073/pnas.180313297.
Article CAS PubMed PubMed Central Google Scholar
Bagno LL, Kanashiro-Takeuchi RM, Suncion VY, Golpanian S, Karantalis V, Wolf A, Wang B, Premer C, Balkan W, Rodriguez J, Valdes D, Rosado M, Block NL, Goldstein P, Morales A, Cai RZ, Sha W, Schally AV, Hare JM. Growth hormone-releasing hormone agonists reduce myocardial infarct scar in swine with subacute ischemic cardiomyopathy. J Am Heart Assoc. 2015;4(4). https://doi.org/10.1161/jaha.114.001464
Louzada RA, Blandino-Rosano M, Flores S, Lubaczeuski C, Cui T, Sha W, Cai R, Schally AV, Bernal-Mizrachi E. GHRH agonist MR-409 protects β-cells from streptozotocin-induced diabetes. Proc Natl Acad Sci U S A. 2023;120(25):e2209810120. https://doi.org/10.1073/pnas.2209810120.
Article CAS PubMed PubMed Central Google Scholar
Carro E, Seoane LM, Señaris R, Casanueva FF, Dieguez C. Leptin increases in vivo GH responses to GHRH and GH-releasing peptide-6 in food-deprived rats. Eur J Endocrinol. 2000;142(1):66–70. https://doi.org/10.1530/eje.0.1420066.
Article CAS PubMed Google Scholar
Thounaojam MC, Powell FL, Patel S, Gutsaeva DR, Tawfik A, Smith SB, Nussbaum J, Block NL, Martin PM, Schally AV, Bartoli M. Protective effects of agonists of growth hormone-releasing hormone (GHRH) in early experimental diabetic retinopathy. Proc Natl Acad Sci U S A. 2017;114(50):13248–53. https://doi.org/10.1073/pnas.1718592114.
Article CAS PubMed PubMed Central Google Scholar
Ye R, Wang HL, Zeng DW, Chen T, Sun JJ, Xi QY, Zhang YL. GHRH expression plasmid improves osteoporosis and skin damage in aged mice. Growth Horm IGF Res. 2021;60–61:101429. https://doi.org/10.1016/j.ghir.2021.101429.
Article CAS PubMed Google Scholar
VadakkadathMeethal S, Atwood CS. The role of hypothalamic-pituitary-gonadal hormones in the normal structure and functioning of the brain. Cell Mol Life Sci. 2005;62(3):257–70. https://doi.org/10.1007/s00018-004-4381-3.
Veldhuis JD. Neuroendocrine facets of human puberty. Neurobiol Aging, 2003;24 Suppl 1:S93-S119; discussion S121–2. https://doi.org/10.1016/s0197-4580(03)00058-7
Chesnokova V, Zhou C, Ben-Shlomo A, Zonis S, Tani Y, Ren SG, Melmed S. Growth hormone is a cellular senescence target in pituitary and nonpituitary cells. Proc Natl Acad Sci U S A. 2013;110(35):E3331–9. https://doi.org/10.1073/pnas.1310589110.
Article PubMed PubMed Central Google Scholar
Xu XQ, Emerald BS, Goh EL, Kannan N, Miller LD, Gluckman PD, Liu ET, Lobie PE. Gene expression profiling to identify oncogenic determinants of autocrine human growth hormone in human mammary carcinoma. J Biol Chem. 2005;280(25):23987–4003. https://doi.org/10.1074/jbc.M503869200.
Article CAS PubMed Google Scholar
Hull KL, Harvey S. Growth hormone and reproduction: a review of endocrine and autocrine/paracrine interactions. Int J Endocrinol. 2014;2014:234014.
留言 (0)