Iwama S, Welt CK, Romero CJ, Radovick S, Caturegli P. Isolated prolactin deficiency associated with serum autoantibodies against prolactin-secreting cells. J Clin Endocrinol Metab. 2013;98(10):3920–5.

Article  PubMed Central  Google Scholar 

Benson CT. Prolactin Medscape: Medscape; 2023. Available from: https://emedicine.medscape.com/article/124526-overview?form=fpf. Accessed 27 Dec 2023.

Amin M, Gragnoli C. The prolactin receptor gene (PRLR) is linked and associated with the risk of polycystic ovarian syndrome. J Ovarian Res. 2023;16(1):222.

Article  PubMed Central  Google Scholar 

Le JA, Wilson HM, Shehu A, Mao J, Devi YS, Halperin J, et al. Generation of mice expressing only the long form of the prolactin receptor reveals that both isoforms of the receptor are required for normal ovarian function. Biol Reprod. 2012;86(3):86.

Article  Google Scholar 

Baumgard LH, Hausman GJ, Sanz Fernandez MV. Insulin: pancreatic secretion and adipocyte regulation. Domest Anim Endocrinol. 2016;54:76–84.

Article  Google Scholar 

Macotela Y, Triebel J, Clapp C. Time for a New Perspective on Prolactin in Metabolism. Trends Endocrinol Metab. 2020;31(4):276–86.

Article  Google Scholar 

Zhang Z, Piro AL, Allalou A, Alexeeff SE, Dai FF, Gunderson EP, et al. Prolactin and Maternal Metabolism in Women With a Recent GDM Pregnancy and Links to Future T2D: The SWIFT Study. J Clin Endocrinol Metab. 2022;107(9):2652–65.

Article  PubMed Central  Google Scholar 

Fleenor DE, Freemark M. Prolactin induction of insulin gene transcription: roles of glucose and signal transducer and activator of transcription 5. Endocrinology. 2001;142(7):2805–10.

Article  Google Scholar 

Mráziková L, Neprašová B, Mengr A, Popelová A, Strnadová V, Holá L, et al. Lipidized Prolactin-Releasing Peptide as a New Potential Tool to Treat Obesity and Type 2 Diabetes Mellitus: Preclinical Studies in Rodent Models. Front Pharmacol. 2021;12:779962.

Article  PubMed Central  Google Scholar 

Kooijman R, Gerlo S, Coppens A, Hooghe-Peters EL. Growth hormone and prolactin expression in the immune system. Ann N Y Acad Sci. 2000;917:534–40.

Article  Google Scholar 

Gregory LC, Cionna C, Cerbone M, Dattani MT. Identification of genetic variants and phenotypic characterization of a large cohort of patients with congenital hypopituitarism and related disorders. Genet Med. 2023;25(9):100881.

Article  Google Scholar 

Aitkenhead H, Heales SJ. Establishment of paediatric age-related reference intervals for serum prolactin to aid in the diagnosis of neurometabolic conditions affecting dopamine metabolism. Ann Clin Biochem. 2013;50(Pt 2):156–8.

Article  Google Scholar 

Davis SW, Castinetti F, Carvalho LR, Ellsworth BS, Potok MA, Lyons RH, et al. Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes. Mol Cell Endocrinol. 2010;323(1):4–19.

Article  Google Scholar 

Procter AM, Phillips JA 3rd, Cooper DN. The molecular genetics of growth hormone deficiency. Hum Genet. 1998;103(3):255–72.

Article  Google Scholar 

Mukherjee A, Ryder WD, Jöstel A, Shalet SM. Prolactin deficiency is independently associated with reduced insulin-like growth factor I status in severely growth hormone-deficient adults. J Clin Endocrinol Metab. 2006;91(7):2520–5.

Article  Google Scholar 

Veldhuis JD. Changes in pituitary function with ageing and implications for patient care. Nat Rev Endocrinol. 2013;9(4):205–15.

Article  PubMed Central  Google Scholar 

Alatzoglou KS, Dattani MT. Genetic forms of hypopituitarism and their manifestation in the neonatal period. Early Hum Dev. 2009;85(11):705–12.

Article  Google Scholar 

Bosch IAL, Katugampola H, Dattani MT. Congenital Hypopituitarism During the Neonatal Period: Epidemiology, Pathogenesis, Therapeutic Options, and Outcome. Front Pediatr. 2020;8:600962.

Article  Google Scholar 

Blum WF, Klammt J, Amselem S, Pfäffle HM, Legendre M, Sobrier ML, et al. Screening a large pediatric cohort with GH deficiency for mutations in genes regulating pituitary development and GH secretion: Frequencies, phenotypes and growth outcomes. EBioMedicine. 2018;36:390–400.

Article  PubMed Central  Google Scholar 

Kelberman D, Dattani MT. Genetics of septo-optic dysplasia. Pituitary. 2007;10(4):393–407.

Article  Google Scholar 

Turton JP, Reynaud R, Mehta A, Torpiano J, Saveanu A, Woods KS, et al. Novel mutations within the POU1F1 gene associated with variable combined pituitary hormone deficiency. J Clin Endocrinol Metab. 2005;90(8):4762–70.

Article  Google Scholar 

Toledano Y, Lubetsky A, Shimon I. Acquired prolactin deficiency in patients with disorders of the hypothalamic-pituitary axis. J Endocrinol Invest. 2007;30(4):268–73.

Article  Google Scholar 

Uzun I, Karaca Z, Hacioğlu A, Unluhizarci K, Kelestimur F. The diagnosis and prevalence of hypoprolactinemia in patients with panhypopituitarism and the effects on depression and sexual functions. Pituitary. 2024;27(3):277.

Article  PubMed Central  Google Scholar 

Krysiak R, Kowalcze K, Okopień B. Sexual function and depressive symptoms in young women with hypoprolactinaemia. Clin Endocrinol (Oxf). 2020;93(4):482–8.

Article  Google Scholar 

Oseko F, Nakano A, Morikawa K, Endo J, Taniguchi A, Usui T. Effects of chronic bromocriptine-induced hypoprolactinemia on plasma testosterone responses to human chorionic gonadotropin stimulation in normal men. Fertil Steril. 1991;55(2):355–7.

Article  Google Scholar 

Rastrelli G, Corona G, Maggi M. The role of prolactin in andrology: what is new? Rev Endocr Metab Disord. 2015;16(3):233–48.

Article  Google Scholar 

Gács G, Sólyom J, Jakabfi P, Fehér T. Does hypoprolactinaemia affect adrenal androgen levels in children with hypopituitarism? Horm Metab Res. 1989;21(9):529–30.

Article  Google Scholar 

Macotela Y, Ruiz-Herrera X, Vázquez-Carrillo DI, Ramírez-Hernandez G. Martínez de la Escalera G, Clapp C The beneficial metabolic actions of prolactin. Front Endocrinol (Lausanne). 2022;13:1001703.

Article  Google Scholar 

Ruiz-Herrera X, de Los Ríos EA, Díaz JM, Lerma-Alvarado RM, Martínez de la Escalera L, López-Barrera F, et al. Prolactin Promotes Adipose Tissue Fitness and Insulin Sensitivity in Obese Males. Endocrinology 2017;158(1):56–68.

Holstad M, Sandler S. Prolactin protects against diabetes induced by multiple low doses of streptozotocin in mice. J Endocrinol. 1999;163(2):229–34.

Article  Google Scholar 

Park S, Kim DS, Daily JW, Kim SH. Serum prolactin concentrations determine whether they improve or impair β-cell function and insulin sensitivity in diabetic rats. Diabetes Metab Res Rev. 2011;27(6):564–74.

Article  Google Scholar 

Yu J, Xiao F, Zhang Q, Liu B, Guo Y, Lv Z, et al. PRLR regulates hepatic insulin sensitivity in mice via STAT5. Diabetes. 2013;62(9):3103–13.

Article  PubMed Central  Google Scholar 

Ponce AJ, Galván-Salas T, Lerma-Alvarado RM, Ruiz-Herrera X, Hernández-Cortés T, Valencia-Jiménez R, et al. Low prolactin levels are associated with visceral adipocyte hypertrophy and insulin resistance in humans. Endocrine. 2020;67(2):331–43.

Article  Google Scholar 

Krysiak R, Kowalcze K, Okopień B. Cardiometabolic profile of young women with hypoprolactinemia. Endocrine. 2022;78(1):135–41.

Article  PubMed Central  Google Scholar 

Maseroli E, Verde N, Cipriani S, Rastrelli G, Alfaroli C, Ravelli SA, et al. Low prolactin level identifies hypoactive sexual desire disorder women with a reduced inhibition profile. J Endocrinol Invest. 2023;46(12):2481–92.

Article  PubMed Central  Google Scholar 

Pellegrini I, Lebrun JJ, Ali S, Kelly PA. Expression of prolactin and its receptor in human lymphoid cells. Mol Endocrinol. 1992;6(7):1023–31.

Google Scholar 

Dimitrov S, Lange T, Fehm HL, Born J. A regulatory role of prolactin, growth hormone, and corticosteroids for human T-cell production of cytokines. Brain Behav Immun. 2004;18(4):368–74.

Article  Google Scholar 

Gala RR, Shevach EM. Identification by analytical flow cytometry of prolactin receptors on immunocompetent cell populations in the mouse. Endocrinology. 1993;133(4):1617–23.

Article  Google Scholar 

Sheng HZ, Westphal H. Early steps in pituitary organogenesis. Trends Genet. 1999;15(6):236–40.

Article  Google Scholar 

Gregory LC, Dattani MT. The Molecular Basis of Congenital Hypopituitarism and Related Disorders. J Clin Endocrinol Metab. 2020;105(6):e2103.

Article  Google Scholar 

Shields R, Mangla R, Almast J, Meyers S. Magnetic resonance imaging of sellar and juxtasellar abnormalities in the paediatric population: an imaging review. Insights Imaging. 2015;6(2):241–60.

Article  PubMed Central  Google Scholar 

Kawamura K, Kouki T, Kawahara G, Kikuyama S. Hypophyseal development in vertebrates from amphibians to mammals. Gen Comp Endocrinol. 2002;126(2):130–5.

Article  Google Scholar 

Osumi-Yamashita N, Ninomiya Y, Doi H, Eto K. The contribution of both forebrain and midbrain crest cells to the mesenchyme in the frontonasal mass of mouse embryos. Dev Biol. 1994;164(2):409–19.

Article  Google Scholar 

Treier M, Rosenfeld MG. The hypothalamic-pituitary axis: co-development of two organs. Curr Opin Cell Biol. 1996;8(6):833–43.