GHRH and its analogues in central nervous system diseases

Bhat MA, Dhaneshwar S. <ArticleTitle Language="En">Neurodegenerative diseases: new hopes and perspectives. Curr Mol Med. 2024;24:1004–32.

Article  PubMed  CAS  Google Scholar 

Dugger BN, Dickson DW. Pathology of Neurodegenerative Diseases. Cold Spring Harb Perspect Biol. 2017;9.

Wareham LK, Liddelow SA, Temple S, Benowitz LI, Di Polo A, Wellington C, et al. Solving neurodegeneration: common mechanisms and strategies for new treatments. Mol Neurodegener. 2022;17:23.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Karran E, De Strooper B. The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics. Nat Rev Drug Discov. 2022;21:306–18.

Article  PubMed  CAS  Google Scholar 

Zefferino R, Di Gioia S, Conese M. Molecular links between endocrine, nervous and immune system during chronic stress. Brain Behav. 2021;11:e01960.

Article  PubMed  CAS  Google Scholar 

Donato J Jr., Kopchick JJ. New findings on brain actions of growth hormone and potential clinical implications. Rev Endocr Metab Disord. 2024;25:541–53.

Article  PubMed  Google Scholar 

Wasinski F, Frazao R, Donato J. Jr. Effects of growth hormone in the central nervous system. Arch Endocrinol Metab. 2019;63:549–56.

Article  PubMed  PubMed Central  Google Scholar 

Muller EE, Locatelli V, Cocchi D. Neuroendocrine control of growth hormone secretion. Physiol Rev. 1999;79:511–607.

Article  PubMed  CAS  Google Scholar 

Al-Samerria S, Radovick S. The Role of Insulin-like Growth Factor-1 (IGF-1) in the Control of Neuroendocrine Regulation of Growth. Cells. 2021;10.

Bianchi VE, Locatelli V, Rizzi L. Neurotrophic and Neuroregenerative Effects of GH/IGF1. Int J Mol Sci. 2017;18.

Liao F, Taishi P, Churchill L, Urza MJ, Krueger JM. Localized suppression of cortical growth hormone-releasing hormone receptors state-specifically attenuates electroencephalographic delta waves. J Neurosci. 2010;30:4151–9.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mezey G, Treszl A, Schally AV, Block NL, Vizkeleti L, Juhasz A, et al. Prognosis in human glioblastoma based on expression of ligand growth hormone-releasing hormone, pituitary-type growth hormone-releasing hormone receptor, its splicing variant receptors, EGF receptor and PTEN genes. J Cancer Res Clin Oncol. 2014;140:1641–9.

Article  PubMed  CAS  Google Scholar 

Gaylinn BD. Molecular and cell biology of the growth hormone-releasing hormone receptor. Growth Horm IGF Res. 1999;9(Suppl A):37–44.

Article  PubMed  CAS  Google Scholar 

Zhou F, Zhang H, Cong Z, Zhao LH, Zhou Q, Mao C, et al. Structural basis for activation of the growth hormone-releasing hormone receptor. Nat Commun. 2020;11:5205.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Akhter MS, Barabutis N. Suppression of reactive oxygen species in endothelial cells by an antagonist of growth hormone-releasing hormone. J Biochem Mol Toxicol. 2021;35:e22879.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Barabutis N, Akhter MS, Uddin MA, Kubra KT, Schally AV. GHRH Antagonists Protect Against Hydrogen Peroxide-Induced Breakdown of Brain Microvascular Endothelium Integrity. Horm Metab Res. 2020;52:336–239.

Article  PubMed  CAS  Google Scholar 

Granata R. Peripheral activities of growth hormone-releasing hormone. J Endocrinol Invest. 2016;39:721–7.

Article  PubMed  CAS  Google Scholar 

Barabutis N, Schally AV. Growth hormone-releasing hormone: extrapituitary effects in physiology and pathology. Cell Cycle. 2010;9:4110–6.

Article  PubMed  CAS  Google Scholar 

Scheltens P, De Strooper B, Kivipelto M, Holstege H, Chetelat G, Teunissen CE, et al. Alzheimer’s disease. Lancet. 2021;397:1577–90.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rostagno AA. Pathogenesis of Alzheimer’s Disease. Int J Mol Sci. 2022;24.

Liao F, Zhang TJ, Mahan TE, Jiang H, Holtzman DM. Effects of growth hormone-releasing hormone on sleep and brain interstitial fluid amyloid-beta in an APP transgenic mouse model. Brain Behav Immun. 2015;47:163–71.

Article  PubMed  CAS  Google Scholar 

Vitiello MV, Moe KE, Merriam GR, Mazzoni G, Buchner DH, Schwartz RS. Growth hormone releasing hormone improves the cognition of healthy older adults. Neurobiol Aging. 2006;27:318–23.

Article  PubMed  CAS  Google Scholar 

Baker LD, Barsness SM, Borson S, Merriam GR, Friedman SD, Craft S, et al. Effects of growth hormone-releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial. Arch Neurol. 2012;69:1420–9.

Article  PubMed  PubMed Central  Google Scholar 

Friedman SD, Baker LD, Borson S, Jensen JE, Barsness SM, Craft S, et al. Growth hormone-releasing hormone effects on brain gamma-aminobutyric acid levels in mild cognitive impairment and healthy aging. JAMA Neurol. 2013;70:883–90.

Article  PubMed  PubMed Central  Google Scholar 

Baum HB, Katznelson L, Sherman JC, Biller BM, Hayden DL, Schoenfeld DA, et al. Effects of physiological growth hormone (GH) therapy on cognition and quality of life in patients with adult-onset GH deficiency. J Clin Endocrinol Metab. 1998;83:3184–9.

PubMed  CAS  Google Scholar 

Deijen JB, de Boer H, Blok GJ, van der Veen EA. Cognitive impairments and mood disturbances in growth hormone deficient men. Psychoneuroendocrinology. 1996;21:313–22.

Article  PubMed  CAS  Google Scholar 

Papadakis MA, Grady D, Black D, Tierney MJ, Gooding GA, Schambelan M, et al. Growth hormone replacement in healthy older men improves body composition but not functional ability. Ann Intern Med. 1996;124:708–16.

Article  PubMed  CAS  Google Scholar 

Soares CN, Musolino NR, Cunha Neto M, Caires MA, Rosenthal MC, Camargo CP, et al. Impact of recombinant human growth hormone (RH-GH) treatment on psychiatric, neuropsychological and clinical profiles of GH deficient adults. A placebo-controlled trial. Arq Neuropsiquiatr. 1999;57:182–9.

Article  PubMed  CAS  Google Scholar 

Friedlander AL, Butterfield GE, Moynihan S, Grillo J, Pollack M, Holloway L, et al. One year of insulin-like growth factor I treatment does not affect bone density, body composition, or psychological measures in postmenopausal women. J Clin Endocrinol Metab. 2001;86:1496–503.

PubMed  CAS  Google Scholar 

Deak F, Sonntag WE. Aging, synaptic dysfunction, and insulin-like growth factor (IGF)-1. J Gerontol Biol Sci Med Sci. 2012;67:611–25.

Article  Google Scholar 

Gomez JM. Growth hormone and insulin-like growth factor-I as an endocrine axis in Alzheimer’s disease. Endocr Metab Immune Disord Drug Targets. 2008;8:143–51.

Article  PubMed  CAS  Google Scholar 

Lichtenwalner RJ, Forbes ME, Bennett SA, Lynch CD, Sonntag WE, Riddle DR. Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis. Neuroscience. 2001;107:603–13.

Article  PubMed  CAS  Google Scholar 

Markowska AL, Mooney M, Sonntag WE. Insulin-like growth factor-1 ameliorates age-related behavioral deficits. Neuroscience. 1998;87:559–69.

Article  PubMed  CAS  Google Scholar 

Ramsey MM, Weiner JL, Moore TP, Carter CS, Sonntag WE. Growth hormone treatment attenuates age-related changes in hippocampal short-term plasticity and spatial learning. Neuroscience. 2004;129:119–27.

Article  PubMed  CAS 

留言 (0)

沒有登入
gif