Polycystic ovary syndrome as a metabolic disease

Lizneva, D. et al. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertil. Steril. 106, 6–15 (2016).

Article  PubMed  Google Scholar 

Bozdag, G., Mumusoglu, S., Zengin, D., Karabulut, E. & Yildiz, B. O. The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis. Hum. Reprod. 31, 2841–2855 (2016).

Article  PubMed  Google Scholar 

Azziz, R. et al. Polycystic ovary syndrome. Nat. Rev. Dis. Prim. 2, 16057 (2016).

Article  PubMed  Google Scholar 

Riestenberg, C., Jagasia, A., Markovic, D., Buyalos, R. P. & Azziz, R. Health care-related economic burden of polycystic ovary syndrome in the United States: pregnancy-related and long-term health consequences. J. Clin. Endocrinol. Metab. 107, 575–585 (2022).

Article  PubMed  Google Scholar 

Ruddenklau, A. & Campbell, R. E. Neuroendocrine impairments of polycystic ovary syndrome. Endocrinology 160, 2230–2242 (2019).

Article  CAS  PubMed  Google Scholar 

Moore, A. M. Impaired steroid hormone feedback in polycystic ovary syndrome: evidence from preclinical models for abnormalities within central circuits controlling fertility. Clin. Endocrinol. 97, 199–207 (2022).

Article  CAS  Google Scholar 

Garg, A., Patel, B., Abbara, A. & Dhillo, W. S. Treatments targeting neuroendocrine dysfunction in polycystic ovary syndrome (PCOS). Clin. Endocrinol. 97, 156–164 (2022).

Article  CAS  Google Scholar 

Cimino, I. et al. Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion. Nat. Commun. 7, 10055 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dewailly, D., Barbotin, A. L., Dumont, A., Catteau-Jonard, S. & Robin, G. Role of anti-Müllerian hormone in the pathogenesis of polycystic ovary syndrome. Front. Endocrinol. 11, 641 (2020).

Article  Google Scholar 

Cassar, S. et al. Insulin resistance in polycystic ovary syndrome: a systematic review and meta-analysis of euglycaemic-hyperinsulinaemic clamp studies. Hum. Reprod. 31, 2619–2631 (2016).

Article  CAS  PubMed  Google Scholar 

Tosi, F., Bonora, E. & Moghetti, P. Insulin resistance in a large cohort of women with polycystic ovary syndrome: a comparison between euglycaemic-hyperinsulinaemic clamp and surrogate indexes. Hum. Reprod. 32, 2515–2521 (2017).

Article  CAS  PubMed  Google Scholar 

Diamanti-Kandarakis, E. & Dunaif, A. Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocr. Rev. 33, 981–1030 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao, H., Zhang, J., Cheng, X., Nie, X. & He, B. Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment. J. Ovarian Res. 16, 9 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Angelidi, A. M., Filippaios, A. & Mantzoros, C. S. Severe insulin resistance syndromes. J. Clin. Invest. 131, e142245 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lungu, A. O., Zadeh, E. S., Goodling, A., Cochran, E. & Gorden, P. Insulin resistance is a sufficient basis for hyperandrogenism in lipodystrophic women with polycystic ovarian syndrome. J. Clin. Endocrinol. Metab. 97, 563–567 (2012).

Article  CAS  PubMed  Google Scholar 

Malek, M. et al. Treatment of type B insulin resistance: a novel approach to reduce insulin receptor autoantibodies. J. Clin. Endocrinol. Metab. 95, 3641–3647 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Long, C. et al. Prevalence of polycystic ovary syndrome in patients with type 2 diabetes: a systematic review and meta-analysis. Front. Endocrinol. 13, 980405 (2022).

Article  Google Scholar 

Bayona, A. et al. Prevalence of PCOS and related hyperandrogenic traits in premenopausal women with type 1 diabetes: a systematic review and meta-analysis. Hum. Reprod. Update 28, 501–517 (2022).

Article  CAS  PubMed  Google Scholar 

Kataoka, J. et al. Prevalence of polycystic ovary syndrome in women with severe obesity – effects of a structured weight loss programme. Clin. Endocrinol. 91, 750–758 (2019).

Article  CAS  Google Scholar 

Teede, H. et al. International evidence-based guideline for the assessment and management of polycystic ovary syndrome 2023. Monash.edu www.monash.edu/__data/assets/pdf_file/0003/3379521/Evidence-Based-Guidelines-2023.pdf (2023).

Brothers, K. J. et al. Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor. Cell Metab. 12, 295–305 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu, C. et al. High-fat and high-sucrose diet impairs female reproduction by altering ovarian transcriptomic and metabolic signatures. J. Transl. Med. 22, 145 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu, S. et al. Obesity-induced infertility and hyperandrogenism are corrected by deletion of the insulin receptor in the ovarian theca cell. Diabetes 63, 1270–1282 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Franks, S., Stark, J. & Hardy, K. Follicle dynamics and anovulation in polycystic ovary syndrome. Hum. Reprod. Update 14, 367–378 (2008).

Article  CAS  PubMed  Google Scholar 

Barber, T. M. et al. Global adiposity rather than abnormal regional fat distribution characterizes women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 93, 999–1004 (2008).

Article  CAS  PubMed  Google Scholar 

Mannerås-Holm, L. et al. Adipose tissue has aberrant morphology and function in PCOS: enlarged adipocytes and low serum adiponectin, but not circulating sex steroids, are strongly associated with insulin resistance. J. Clin. Endocrinol. Metab. 96, E304–E311 (2011).

Article  PubMed  Google Scholar 

Zhu, S. et al. Imaging-based body fat distribution in polycystic ovary syndrome: a systematic review and meta-analysis. Front. Endocrinol. 12, 697223 (2021).

Article  Google Scholar 

Bril, F. et al. Adipose tissue dysfunction in polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 109, 10–24 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Ezeh, U., Chen, I. Y. D., Chen, Y. H. & Azziz, R. Adipocyte expression of glucose transporter 1 and 4 in PCOS: relationship to insulin-mediated and non-insulin-mediated whole-body glucose uptake. Clin. Endocrinol. 90, 542–552 (2019).

Article  CAS  Google Scholar 

Ezeh, U. et al. Alterations in plasma non-esterified fatty acid (NEFA) kinetics and relationship with insulin resistance in polycystic ovary syndrome. Hum. Reprod. 34, 335–344 (2019).

Article  CAS  PubMed  Google Scholar 

Ezeh, U., Chen, I. Y. D., Chen, Y. H. & Azziz, R. Adipocyte insulin resistance in PCOS: relationship with GLUT-4 expression and whole-body glucose disposal and β-cell function. J. Clin. Endocrinol. Metab. 105, e2408–e2420 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Dumesic, D. A. et al. Adipose insulin resistance in normal-weight women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 104, 2171–2183 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Echiburú, B. et al. Enlarged adipocytes in subcutaneous adipose tissue associated to hyperandrogenism and visceral adipose tissue volume in women with polycystic ovary syndrome. Steroids 130, 15–21 (2018).

Article  PubMed  Google Scholar 

Chazenbalk, G. et al. Androgens inhibit adipogenesis during human adipose stem cell commitment to preadipocyte formation. Stero

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