Surveying the landscape of emerging osteoanabolic therapies

Black, D. M., Thompson, A. R., Eastell, R. & Bouxsein, M. L. Bone mineral density as a surrogate endpoint for fracture risk reduction in clinical trials of osteoporosis therapies: an update on SABRE. Lancet Diabetes Endocrinol. 12, 371–373 (2024).

Article  PubMed  CAS  Google Scholar 

Jensen, S. B. K. et al. Bone health after exercise alone, GLP-1 receptor agonist treatment, or combination treatment: a secondary analysis of a randomized clinical trial. JAMA Netw. Open 7, e2416775 (2024).

Article  PubMed  PubMed Central  Google Scholar 

Angitia Incorporated. Angitia Biopharmaceuticals presents first-in-human data on AGA2118 for osteoporosis at ASBMR 2024. GlobeNewswire News Room https://www.globenewswire.com/en/news-release/2024/09/30/2955094/0/en/Angitia-Biopharmaceuticals-Presents-First-in-Human-Data-on-AGA2118-for-Osteoporosis-at-ASBMR-2024.html (2024).

Babey, M. E. et al. A maternal brain hormone that builds bone. Nature 632, 357–365 (2024).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li, N. et al. Schnurri-3 inhibition rescues skeletal fragility and vascular skeletal stem cell niche pathology in the OIM model of osteogenesis imperfecta. Bone Res. 12, 46 (2024).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Collins, J. M. et al. YAP and TAZ couple osteoblast precursor mobilization to angiogenesis and mechanoregulation in murine bone development. Dev. Cell 59, 211–227.e5 (2024).

Article  PubMed  CAS  Google Scholar 

Bandyopadhyay, S. et al. Mapping the cellular biogeography of human bone marrow niches using single-cell transcriptomics and proteomic imaging. Cell 187, 3120–3140.e29 (2024).

Article  PubMed  CAS  Google Scholar 

Farr, J. N. et al. Targeting cellular senescence prevents age-related bone loss in mice. Nat. Med. 23, 1072–1079 (2017).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Snyder, P. J. et al. Testosterone treatment and fractures in men with hypogonadism. N. Engl. J. Med. 390, 203–211 (2024).

Article  PubMed  CAS  Google Scholar 

Middelkoop, K. et al. Influence of vitamin D supplementation on bone mineral content, bone turnover markers, and fracture risk in South African schoolchildren: multicenter double-blind randomized placebo-controlled trial (ViDiKids). J. Bone Miner. Res. 39, 211–221 (2024).

Article  PubMed  PubMed Central  Google Scholar 

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