Advances in appetite regulation by the arcuate nucleus

Brandt, C. et al. Food perception primes hepatic ER homeostasis via melanocortin-dependent control of mTOR activation. Cell 175, 1321–1335.e20 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Henschke, S. et al. Food perception promotes phosphorylation of MFFS131 and mitochondrial fragmentation in liver. Science 384, 438–446 (2024).

Article  CAS  PubMed  Google Scholar 

Benevento, M. et al. A brainstem-hypothalamus neuronal circuit reduces feeding upon heat exposure. Nature 628, 826–834 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luquet, S., Perez, F. A., Hnasko, T. S. & Palmiter, R. D. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310, 683–685 (2005).

Article  CAS  PubMed  Google Scholar 

Zhan, C. et al. Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively. J. Neurosci. 33, 3624–3632 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tan, H. L. et al. Leptin-activated hypothalamic BNC2 neurons acutely suppress food intake. Nature (2024).

Cowley, M. A. et al. Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 24, 155–163 (1999).

Article  CAS  PubMed  Google Scholar 

Zhang, S. X. et al. Stochastic neuropeptide signals compete to calibrate the rate of satiation. Nature https://doi.org/10.1038/s41586-024-08164-8 (2024).

Article  PubMed  PubMed Central  Google Scholar 

Beddows, C. A. et al. Pathogenic hypothalamic extracellular matrix promotes metabolic disease. Nature 633, 914–922 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, X. et al. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 135, 61–73 (2008).

Article  CAS  PubMed  PubMed Central  Google Scholar 

留言 (0)

沒有登入
gif