Gregersen H, Liao D, Drewes AM, Drewes AM, Zhao J (2016) Ravages of diabetes on gastrointestinal sensory-motor function: implications for pathophysiology and treatment. Curr Gastroenterol Rep 18(2):6. https://doi.org/10.1007/s11894-015-0481-x

Article  PubMed  Google Scholar 

Travagli RA, Anselmi L (2016) Vagal neurocircuitry and its influence on gastric motility. Nat Rev Gastroenterol Hepatol 13(7):389–401. https://doi.org/10.1038/nrgastro.2016.76

Article  PubMed  PubMed Central  CAS  Google Scholar 

Klinge MW, Borghammer P, Lund S et al (2020) Enteric cholinergic neuropathy in patients with diabetes: non-invasive assessment with positron emission tomography. Neurogastroenterol Motil 32(1):e13731. https://doi.org/10.1111/nmo.13731

Article  PubMed  CAS  Google Scholar 

Sellin JH, Chang EB (2008) Therapy Insight: gastrointestinal complications of diabetes–pathophysiology and management. Nat Clin Pract Gastroenterol Hepatol 5(3):162–171. https://doi.org/10.1038/ncpgasthep1054

Article  PubMed  Google Scholar 

Sangnes DA, Sandvik Bergmann E, Moss RM, Engjom T, Søfteland E (2021) Pancreatic exocrine insufficiency in diabetes is associated with autonomic dysfunction. Scand J Gastroenterol 56(10):1222–1228. https://doi.org/10.1080/00365521.2021.1957496

Article  PubMed  CAS  Google Scholar 

Pazzi P, Scagliarini R, Gamberini S, Pezzoli A (2000) Review article: gall-bladder motor function in diabetes mellitus. Aliment Pharmacol Ther 14(Suppl 2):62–65. https://doi.org/10.1046/j.1365-2036.2000.014s2062.x

Article  PubMed  Google Scholar 

Phillips LK, Deane AM, Jones KL, Rayner CK, Horowitz M (2015) Gastric emptying and glycaemia in health and diabetes mellitus. Nat Rev Endocrinol 11(2):112–128. https://doi.org/10.1038/nrendo.2014.202

Article  PubMed  CAS  Google Scholar 

Bharucha AE, Kudva YC, Prichard DO (2019) Diabetic Gastroparesis. Endocr Rev 40(5):1318–1352. https://doi.org/10.1210/er.2018-00161

Article  PubMed  PubMed Central  Google Scholar 

Kornum DS, Brock C, Okdahl T et al (2024) Diabetic gastroenteropathy: associations between gastrointestinal symptoms, motility, and extraintestinal autonomic measures. Neurogastroenterol Motil e14956. https://doi.org/10.1111/nmo.14956

Bytzer P, Talley NJ, Leemon M, Young LJ, Jones MP, Horowitz M (2001) Prevalence of gastrointestinal symptoms associated with diabetes mellitus: a population-based survey of 15,000 adults. Arch Intern Med 161(16):1989–1996. https://doi.org/10.1001/archinte.161.16.1989

Article  PubMed  CAS  Google Scholar 

Gaede P, Lund-Andersen H, Parving HH, Pedersen O (2008) Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med 358(6):580–591. https://doi.org/10.1056/NEJMoa0706245

Article  PubMed  CAS  Google Scholar 

Muroi K, Miyahara R, Funasaka K et al (2020) Comparison of high-resolution manometry in patients complaining of dysphagia among patients with or without diabetes mellitus. Digestion 102(4):554–562. https://doi.org/10.1159/000510081

Gustafsson RJ, Littorin B, Berntorp K et al (2011) Esophageal dysmotility is more common than gastroparesis in diabetes mellitus and is associated with retinopathy. Rev Diabet Stud 8(2):268–275. https://doi.org/10.1900/rds.2011.8.268

Article  PubMed  PubMed Central  Google Scholar 

Kinekawa F, Kubo F, Matsuda K et al (2008) Esophageal function worsens with long duration of diabetes. J Gastroenterol 43(5):338–344. https://doi.org/10.1007/s00535-008-2169-6

Article  PubMed  Google Scholar 

Zhao J, Gregersen H (2016) Diabetes-induced mechanophysiological changes in the esophagus. Ann N Y Acad Sci 1380(1):139–154. https://doi.org/10.1111/nyas.13180

Article  PubMed  Google Scholar 

Frøkjaer JB, Brock C, Brun J et al (2012) Esophageal distension parameters as potential biomarkers of impaired gastrointestinal function in diabetes patients. Neurogastroenterol Motil 24(11):1016-e1544. https://doi.org/10.1111/j.1365-2982.2012.01966.x

Article  PubMed  Google Scholar 

Frøkjær JB, Due Andersen S, Ejskjær N et al (2007) Gut sensations in diabetic autonomic neuropathy. Pain 131(3):320–329. https://doi.org/10.1016/j.pain.2007.04.009

Article  PubMed  Google Scholar 

Brock C, Graversen C, Frokjaer JB, Softeland E, Valeriani M, Drewes AM (2013) Peripheral and central nervous contribution to gastrointestinal symptoms in diabetic patients with autonomic neuropathy. Eur J Pain (London, England) 17(6):820–831. https://doi.org/10.1002/j.1532-2149.2012.00254.x

Article  CAS  Google Scholar 

Monreal-Robles R, Remes-Troche JM (2017) Diabetes and the esophagus. Curr Treat Options Gastroenterol 15(4):475–489. https://doi.org/10.1007/s11938-017-0153-z

Article  PubMed  Google Scholar 

Sun XM, Tan JC, Zhu Y, Lin L (2015) Association between diabetes mellitus and gastroesophageal reflux disease: a meta-analysis. World J Gastroenterol 21(10):3085–3092. https://doi.org/10.3748/wjg.v21.i10.3085

Article  PubMed  PubMed Central  Google Scholar 

Wilson JA, Vela MF (2008) New esophageal function testing (impedance, Bravo pH monitoring, and high-resolution manometry): clinical relevance. Curr Gastroenterol Rep 10(3):222–230. https://doi.org/10.1007/s11894-008-0047-2

Article  PubMed  Google Scholar 

Horváth VJ, Izbéki F, Lengyel C, Kempler P, Várkonyi T (2014) Diabetic gastroparesis: functional/morphologic background, diagnosis, and treatment options. Curr Diab Rep 14(9):527. https://doi.org/10.1007/s11892-014-0527-8

Article  PubMed  CAS  Google Scholar 

Horowitz M, O’Donovan D, Jones KL, Feinle C, Rayner CK, Samsom M (2002) Gastric emptying in diabetes: clinical significance and treatment. Diabet Med 19(3):177–194. https://doi.org/10.1046/j.1464-5491.2002.00658.x

Article  PubMed  CAS  Google Scholar 

Du YT, Rayner CK, Jones KL, Talley NJ, Horowitz M (2018) Gastrointestinal symptoms in diabetes: prevalence, assessment, pathogenesis, and management. Diabetes Care 41(3):627–637. https://doi.org/10.2337/dc17-1536

Article  PubMed  CAS  Google Scholar 

Chedid V, Brandler J, Vijayvargiya P, Park SY, Szarka LA, Camilleri M (2019) Characterization of upper gastrointestinal symptoms, gastric motor functions, and associations in patients with diabetes at a referral center. Am J Gastroenterol 114(1):143–154. https://doi.org/10.1038/s41395-018-0234-1

Article  PubMed  Google Scholar 

Ricci JA, Siddique R, Stewart WF, Sandler RS, Sloan S, Farup CE (2000) Upper gastrointestinal symptoms in a U.S. national sample of adults with diabetes. Scand J Gastroenterol 35(2):152–159. https://doi.org/10.1080/003655200750024317

Article  PubMed  CAS  Google Scholar 

Wu T, Rayner CK, Young RL, Horowitz M (2013) Gut motility and enteroendocrine secretion. Curr Opin Pharmacol 13(6):928–934. https://doi.org/10.1016/j.coph.2013.09.002

Article  PubMed  CAS  Google Scholar 

Brock C, Liao D, Wegeberg AM, Mohr Drewes A (2021) The antroduodenal transition time is prolonged in adults with type 1 diabetes. Neurogastroenterol Motil 33(11):e14144. https://doi.org/10.1111/nmo.14144

Article  PubMed  CAS  Google Scholar 

Kumar A, Attaluri A, Hashmi S, Schulze KS, Rao SS (2008) Visceral hypersensitivity and impaired accommodation in refractory diabetic gastroparesis. Neurogastroenterol Motil 20(6):635–642. https://doi.org/10.1111/j.1365-2982.2008.01081.x

Article  PubMed  CAS  Google Scholar 

Debourdeau A, Gonzalez JM, Mathias F, Prost C, Barthet M, Vitton V (2024) Gastric volumetry for the assessment of fundic compliance and visceral hypersensitivity in patients with gastroparesis: a retrospective comparative study. Scand J Gastroenterol 59(3):254–259. https://doi.org/10.1080/00365521.2023.2279928

Article  PubMed  Google Scholar 

Harsch IA, Koebnick C, Tasi AM, Hahn EG, Konturek PC (2009) Ghrelin and obestatin levels in type 2 diabetic patients with and without delayed gastric emptying. Dig Dis Sci 54(10):2161–2166. https://doi.org/10.1007/s10620-008-0622-2