The dual role of PTPN22 in immune modulation and transplantation tolerance

Wu J, Katrekar A, Honigberg LA, Smith AM, Conn MT, Tang J, et al. Identification of substrates of human protein-tyrosine phosphatase PTPN22. J Biol Chem. 2006;281:11002–10.

Article  CAS  PubMed  Google Scholar 

Kocher A. The treatment of hypothyroidism by thyroid transplantation. Br Med J. 1923;2:560–1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Binti S, Linder AG, Edeen PT, Fay DS. A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in C. elegans. PLoS Genet. 2024. https://doi.org/10.1371/journal.pgen.1011219.

Article  PubMed  PubMed Central  Google Scholar 

Brownlie RJ, Zamoyska R, Salmond RJ. Regulation of autoimmune and anti-tumour T-cell responses by PTPN22. Immunology. 2018;154:377–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu X, Sun JP, He Y, Guo X, Liu S, Zhou B, et al. Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases. Proc Natl Acad Sci U S A. 2007;104:19767–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ivashkiv LB. PTPN22 in autoimmunity: different cell and different way. Immunity. 2013;39:91–3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Shaked I, Stanford SM, Zhou W, Curtsinger JM, Mikulski Z, et al. The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity. 2013;39:111–22.

Article  CAS  PubMed  Google Scholar 

Spalinger MR, Lang S, Vavricka SR, Fried M, Rogler G, Scharl M. Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy. PLoS ONE. 2013;8:e72384.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhuang C, Yang S, Gonzalez CG, Ainsworth RI, Li S, Kobayashi MT, et al. A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling. J Biol Chem. 2024;300:107393.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hasegawa K, Martin F, Huang G, Tumas D, Diehl L, Chan AC. PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells. Science. 2004;303:685–9.

Article  CAS  PubMed  Google Scholar 

Bai B, Li T, Zhao J, Zhao Y, Zhang X, Wang T, et al. The tyrosine phosphatase activity of PTPN22 is involved in T Cell development via the regulation of TCR expression. Int J Mol Sci. 2023. https://doi.org/10.3390/ijms241914505.

Article  PubMed  PubMed Central  Google Scholar 

Jassim BA, Lin J, Zhang ZY. PTPN22: structure, function, and developments in inhibitor discovery with applications for immunotherapy. Expert Opin Drug Discov. 2022;17:825–37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Armitage LH, Wallet MA, Mathews CE. Influence of PTPN22 allotypes on innate and adaptive immune function in health and disease. Front Immunol. 2021. https://doi.org/10.3389/fimmu.2021.636618.

Article  PubMed  PubMed Central  Google Scholar 

Ho WJ, Croessmann S, Lin J, Phyo ZH, Charmsaz S, Danilova L, et al. Systemic inhibition of PTPN22 augments anticancer immunity. J Clin Invest. 2021. https://doi.org/10.1172/JCI146950.

Article  PubMed  PubMed Central  Google Scholar 

Ho WJ, Lin J, Danilova L, Phyo Z, Charmsaz S, Mohan A, et al. Abstract 3398: PTPN22 is a systemic target for augmenting antitumor immunity. Cancer Res. 2020;80:3398.

Article  Google Scholar 

Budding K, van Setten J, van de Graaf EA, van Rossum OA, Kardol-Hoefnagel T, Kwakkel-van Erp JM, et al. The autoimmune-associated single nucleotide polymorphism within PTPN22 correlates with clinical outcome after lung transplantation. Front Immunol. 2019. https://doi.org/10.3389/fimmu.2018.03105.

Article  PubMed  PubMed Central  Google Scholar 

Beyza G, Ali OG. Tissue-specific immunity for transplantable endocrine glands in the context of HLA Expression. In: Sevim G, editor. Human Leukocyte Antigens Rijeka. NY: IntechOpen; 2023.

Google Scholar 

留言 (0)

沒有登入
gif