Ahmetspahic D, Schwarte K, Ambrée O et al (2018) Altered B cell homeostasis in patients with major depressive disorder and normalization of CD5 Surface expression on Regulatory B cells in treatment responders. J Neuroimmune Pharmacol 13:90–99. https://doi.org/10.1007/s11481-017-9763-4

Article  PubMed  Google Scholar 

Ashour ML, Wink M (2011) Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action. J Pharm Pharmacol 63:305–321. https://doi.org/10.1111/j.2042-7158.2010.01170.x

Article  CAS  PubMed  Google Scholar 

Barnes BJ, Adrover JM, Baxter-Stoltzfus A et al (2020) Targeting potential drivers of COVID-19: Neutrophil extracellular traps. J Exp Med 217:e20200652. https://doi.org/10.1084/jem.20200652

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beura S, Chetti P (2021) In-silico strategies for probing chloroquine based inhibitors against SARS-CoV-2. J Biomol Struct Dyn 39:3747–3759. https://doi.org/10.1080/07391102.2020.1772111

Article  CAS  PubMed  Google Scholar 

Bindea G, Mlecnik B, Tosolini M et al (2013) Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity 39:782–795. https://doi.org/10.1016/j.immuni.2013.10.003

Article  CAS  PubMed  Google Scholar 

Chen S, Zhou H, Zhang G et al (2019) Anthocyanins from Lycium Ruthenicum Murr. Ameliorated d-Galactose-Induced memory impairment, oxidative stress, and Neuroinflammation in adult rats. J Agric Food Chem 67:3140–3149. https://doi.org/10.1021/acs.jafc.8b06402

Article  CAS  PubMed  Google Scholar 

Chen S, Tang Y, Gao Y et al (2022) Antidepressant potential of Quercetin and its glycoside derivatives: a Comprehensive Review and Update. Front Pharmacol 13:865376. https://doi.org/10.3389/fphar.2022.865376

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Zhang Y, Wang J et al (2023) Anti-neuroinflammation effects of transcutaneous auricular vagus nerve stimulation against depression-like behaviors via hypothalamic α7nAchR/JAK2/STAT3/NF-κB pathway in rats exposed to chronic unpredictable mild stress. CNS Neurosci Ther 29:2634–2644. https://doi.org/10.1111/cns.14207

Article  CAS  PubMed  PubMed Central  Google Scholar 

Desforges M, Le Coupanec A, Dubeau P et al (2019) Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the Central Nervous System? Viruses 12:14. https://doi.org/10.3390/v12010014

Article  PubMed  PubMed Central  Google Scholar 

Friedman J, Hastie T, Tibshirani R (2010) Regularization paths for generalized Linear models via Coordinate Descent. J Stat Soft 33. https://doi.org/10.18637/jss.v033.i01

Gale SD, Berrett AN, Erickson LD et al (2018) Association between virus exposure and depression in US adults. Psychiatry Res 261:73–79. https://doi.org/10.1016/j.psychres.2017.12.037

Article  PubMed  Google Scholar 

Gammoh O, Qnais EY, Athamneh RY et al (2023) Unraveling the potential of Isorhamnetin as an adjuvant in Depression Treatment with Escitalopram. CIMB 45:7668–7679. https://doi.org/10.3390/cimb45090484

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao J, Cao C, Shi M et al (2023) Kaempferol inhibits SARS-CoV-2 invasion by impairing heptad repeats-mediated viral fusion. Phytomedicine 118:154942. https://doi.org/10.1016/j.phymed.2023.154942

Article  CAS  PubMed  Google Scholar 

Gasmi A, Mujawdiya PK, Lysiuk R et al (2022) Quercetin in the Prevention and Treatment of Coronavirus infections: a focus on SARS-CoV-2. Pharmaceuticals 15:1049. https://doi.org/10.3390/ph15091049

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo L-T, Wang S-Q, Su J et al (2019) Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway. J Neuroinflammation 16:95. https://doi.org/10.1186/s12974-019-1474-8

Article  PubMed  PubMed Central  Google Scholar 

Hadni H, Elhallaouia M (2022) In silico design of EGFRL858R/T790M/C797S inhibitors via 3D-QSAR, molecular docking, ADMET properties and molecular dynamics simulations

Hamdorf M, Imhof T, Bailey-Elkin B et al (2023) The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm. J Mol Cell Biology mjad 062. https://doi.org/10.1093/jmcb/mjad062

Hoang TN, Pino M, Boddapati AK et al (2021) Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques. Cell 184:460–475e21. https://doi.org/10.1016/j.cell.2020.11.007

Article  CAS  PubMed  Google Scholar 

Ishak S, Aris S, Halim K et al (2017) Molecular Dynamic Simulation of Space and Earth-grown crystal structures of Thermostable T1 lipase Geobacillus zalihae revealed a better structure. Molecules 22:1574. https://doi.org/10.3390/molecules22101574

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khorram M, Tarahhomi A, Van Der Lee A, Excoffier G (2023) Structural, Hirshfeld surface and molecular docking studies of a new organotin(IV)-phosphoric triamide complex and an amidophosphoric acid ester proposed as possible SARS-CoV-2 and Monkeypox inhibitors. Heliyon 9:e17358. https://doi.org/10.1016/j.heliyon.2023.e17358

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kokkosis AG, Madeira MM, Hage Z et al (2024) Chronic psychosocial stress triggers microglial-/macrophage‐induced inflammatory responses leading to neuronal dysfunction and depressive‐related behavior. Glia 72:111–132. https://doi.org/10.1002/glia.24464

Article  CAS  PubMed  Google Scholar 

Krieger E, Vriend G (2014) YASARA View—molecular graphics for all devices—from smartphones to workstations. Bioinformatics 30:2981–2982. https://doi.org/10.1093/bioinformatics/btu426

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lan Z, Yao W, Xie Y et al (2024) Oral troxerutin alleviates Depression symptoms in mice by modulating gut microbiota and Microbial Metabolism. Mol Nutr Food Res 68:2300603. https://doi.org/10.1002/mnfr.202300603

Article  CAS  Google Scholar 

Leite Dantas R, Freff J, Ambrée O et al (2021) Dendritic cells: neglected modulators of Peripheral Immune responses and neuroinflammation in Mood disorders? Cells 10:941. https://doi.org/10.3390/cells10040941

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li H-Y, Wang J, Liang L-F et al (2022) Sirtuin 3 plays a critical role in the antidepressant- and anxiolytic-like effects of Kaempferol. Antioxidants 11:1886. https://doi.org/10.3390/antiox11101886

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin C-H, Chang H-J, Lin M-W et al (2024) Inhibitory efficacy of Main Components of Scutellaria baicalensis on the Interaction between Spike protein of SARS-CoV-2 and human angiotensin-converting enzyme II. IJMS 25:2935. https://doi.org/10.3390/ijms25052935

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Q, He H, Yang J et al (2020) Changes in the global burden of depression from 1990 to 2017: findings from the Global Burden of Disease study. J Psychiatric Res 126:134–140. https://doi.org/10.1016/j.jpsychires.2019.08.002

Article  Google Scholar 

Luo Y, Ali T, Liu Z et al (2023) EPO prevents neuroinflammation and relieves depression via JAK/STAT signaling. Life Sci 333:122102. https://doi.org/10.1016/j.lfs.2023.122102

Article  CAS  PubMed  Google Scholar 

Lyra E, Silva NM, Barros-Aragão FGQ, De Felice FG, Ferreira ST (2022) Inflammation at the crossroads of COVID-19, cognitive deficits and depression. Neuropharmacology 209:109023. https://doi.org/10.1016/j.neuropharm.2022.109023

Article  CAS  Google Scholar 

Mangan MSJ, Olhava EJ, Roush WR et al (2018) Targeting the NLRP3 inflammasome in inflammatory diseases. Nat Rev Drug Discov 17:588–606. https://doi.org/10.1038/nrd.2018.97

Article  CAS