Ahrendsen JT, Nong Y, Huo Y, Steele J, Anderson MP (2023) CD8 cytotoxic T-cell infiltrates and cellular damage in the hypothalamus in human obesity. Acta Neuropathol Commun 11(1):163. https://doi.org/10.1186/s40478-023-01659-x
Article CAS PubMed PubMed Central Google Scholar
Antal B, McMahon LP, Sultan SF, Lithen A, Wexler DJ, Dickerson B, Ratai EM, Mujica-Parodi LR (2022) Type 2 diabetes mellitus accelerates brain aging and cognitive decline: complementary findings from UK Biobank and meta-analyses. eLife 11. https://doi.org/10.7554/eLife.73138
Antila S, Karaman S, Nurmi H, Airavaara M, Voutilainen MH, Mathivet T, Chilov D, Li Z, Koppinen T, Park JH, Fang S, Aspelund A, Saarma M, Eichmann A, Thomas JL, Alitalo K (2017) Development and plasticity of meningeal lymphatic vessels. J Exp Med 214(12):3645–3667. https://doi.org/10.1084/jem.20170391
Article CAS PubMed PubMed Central Google Scholar
Aso Y, Fukushima M, Sagara M, Jojima T, Iijima T, Suzuki K, Momobayashi A, Kasai K, Inukai T (2015) Sitagliptin, a DPP-4 inhibitor, alters the subsets of circulating CD4 + T cells in patients with type 2 diabetes. Diabetes Res Clin Pract 110(3):250–256. https://doi.org/10.1016/j.diabres.2015.10.012
Article CAS PubMed Google Scholar
Baruch K, Ron-Harel N, Gal H, Deczkowska A, Shifrut E, Ndifon W, Mirlas-Neisberg N, Cardon M, Vaknin I, Cahalon L, Berkutzki T, Mattson MP, Gomez-Pinilla F, Friedman N, Schwartz M (2013) CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging. Proc Natl Acad Sci USA 110(6):2264–2269. https://doi.org/10.1073/pnas.1211270110
Article PubMed PubMed Central Google Scholar
Bonifacio E, Ziegler AG, Klingensmith G, Schober E, Bingley PJ, Rottenkolber M, Theil A, Eugster A, Puff R, Peplow C, Buettner F, Lange K, Hasford J, Achenbach P (2015) Effects of high-dose oral insulin on immune responses in children at high risk for type 1 diabetes: the Pre-POINT randomized clinical trial. JAMA 313(15):1541–1549. https://doi.org/10.1001/jama.2015.2928
Article CAS PubMed Google Scholar
Borzouei S, Moghimi H, Zamani A, Behzad M (2021a) Changes in T helper cell-related factors in patients with type 2 diabetes mellitus after empagliflozin therapy. Hum Immunol 82(6):422–428. https://doi.org/10.1016/j.humimm.2021.03.004
Article CAS PubMed Google Scholar
Borzouei S, Mohamadtaheri M, Zamani A, Behzad M (2021b) Reduced frequency and functional potency of CD49d(-) T regulatory cells in patients with newly diagnosed type 2 diabetes mellitus. Immunobiology 226(4):152113. https://doi.org/10.1016/j.imbio.2021.152113
Article CAS PubMed Google Scholar
Brook E, Mamo J, Wong R, Al-Salami H, Falasca M, Lam V, Takechi R (2019) Blood-brain barrier disturbances in diabetes-associated dementia: therapeutic potential for cannabinoids. Pharmacol Res 141:291–297. https://doi.org/10.1016/j.phrs.2019.01.009
Article CAS PubMed Google Scholar
Burgaletto C, Munafò A, Di Benedetto G, De Francisci C, Caraci F, Di Mauro R, Bucolo C, Bernardini R, Cantarella G (2020) The immune system on the TRAIL of Alzheimer’s disease. J Neuroinflamm 17(1):298. https://doi.org/10.1186/s12974-020-01968-1
Byrne T, Cooke J, McNeela E, Bambrick P, Murphy RP, Harrison M (2024) Circulating angiogenic and senescent T lymphocytes in Ageing and Frailty. J Frailty Aging 13(3):203–212. https://doi.org/10.14283/jfa.2024.38
Article CAS PubMed Google Scholar
Cai W, Shi L, Zhao J, Xu F, Dufort C, Ye Q, Yang T, Dai X, Lyu J, Jin C, Pu H, Yu F, Hassan S, Sun Z, Zhang W, Hitchens TK, Shi Y, Thomson AW, Leak RK, Hu X, Chen J (2022) Neuroprotection against ischemic stroke requires a specific class of early responder T cells in mice. J Clin Investig 132(15). https://doi.org/10.1172/jci157678
Campbell JE, Király MA, Atkinson DJ, D’Souza AM, Vranic M, Riddell MC (2010) Regular exercise prevents the development of hyperglucocorticoidemia via adaptations in the brain and adrenal glands in male Zucker diabetic fatty rats. Am J Physiol Regul Integr Comp Physiol 299(1):R168–176. https://doi.org/10.1152/ajpregu.00155.2010
Article CAS PubMed Google Scholar
Castellani G, Croese T, Peralta Ramos JM, Schwartz M (2023) Transforming the understanding of brain immunity. Sci (New York NY) 380(6640):eabo7649. https://doi.org/10.1126/science.abo7649
Chatenoud L (2015) Biotherapies targeting T and B cells: from immune suppression to immune tolerance. Curr Opin Pharmacol 23:92–97. https://doi.org/10.1016/j.coph.2015.05.013
Article CAS PubMed Google Scholar
Chen X, Holtzman DM (2022) Emerging roles of innate and adaptive immunity in Alzheimer’s disease. Immunity 55(12):2236–2254. https://doi.org/10.1016/j.immuni.2022.10.016
Article CAS PubMed PubMed Central Google Scholar
Chen Y, Man-Tak Chu J, Liu JX, Duan YJ, Liang ZK, Zou X, Wei M, Xin WJ, Xu T, Tin-Chun Wong G, Feng X (2025) Double negative T cells promote surgery-induced neuroinflammation, microglial engulfment and cognitive dysfunction via the IL-17/CEBPβ/C3 pathway in adult mice. Brain Behav Immun 123:965–981. https://doi.org/10.1016/j.bbi.2024.10.029
Article CAS PubMed Google Scholar
Chi H, Pepper M, Thomas PG (2024) Principles and therapeutic applications of adaptive immunity. Cell 187(9):2052–2078. https://doi.org/10.1016/j.cell.2024.03.037
Article CAS PubMed PubMed Central Google Scholar
Chiou HC, Lin MW, Hsiao PJ, Chen CL, Chiao S, Lin TY, Chen YC, Wu DC, Lin MH (2019) Dulaglutide modulates the development of tissue-infiltrating Th1/Th17 cells and the pathogenicity of encephalitogenic Th1 cells in the Central Nervous System. Int J Mol Sci 20(7). https://doi.org/10.3390/ijms20071584
Ciccocioppo F, Bologna G, Ercolino E, Pierdomenico L, Simeone P, Lanuti P, Pieragostino D, Del Boccio P, Marchisio M, Miscia S (2020) Neurodegenerative diseases as proteinopathies-driven immune disorders. Neural Regeneration Res 15(5):850–856. https://doi.org/10.4103/1673-5374.268971
Cifuentes-Mendiola SE, Solis-Suarez DL, Martínez-Dávalos A, Godínez-Victoria M, García-Hernández AL (2022) CD4(+) T-cell activation of bone marrow causes bone fragility and insulin resistance in type 2 diabetes. Bone 155:116292. https://doi.org/10.1016/j.bone.2021.116292
Article CAS PubMed Google Scholar
Cooper MD (2015) The early history of B cells. Nat Rev Immunol 15(3):191–197. https://doi.org/10.1038/nri3801
Article CAS PubMed Google Scholar
Copp G, Robb KP, Viswanathan S (2023) Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success. Cell Mol Immunol 20(6):626–650. https://doi.org/10.1038/s41423-023-01020-1
Article CAS PubMed PubMed Central Google Scholar
Cukierman-Yaffe T, Gerstein HC, Colhoun HM, Diaz R, García-Pérez L-E, Lakshmanan M, Bethel A, Xavier D, Probstfield J, Riddle MC, Rydén L, Atisso CM, Hall S, Rao-Melacini P, Basile J, Cushman WC, Franek E, Keltai M, Lanas F, Leiter LA, Lopez-Jaramillo P, Pirags V, Pogosova N, Raubenheimer PJ, Shaw JE, Sheu WHH, Temelkova-Kurktschiev T (2020) Effect of dulaglutide on cognitive impairment in type 2 diabetes: an exploratory analysis of the REWIND trial. Lancet Neurol 19(7):582–590. https://doi.org/10.1016/S1474-4422(20)30173-3
Article CAS PubMed Google Scholar
Dansokho C, Ait Ahmed D, Aid S, Toly-Ndour C, Chaigneau T, Calle V, Cagnard N, Holzenberger M, Piaggio E, Aucouturier P, Dorothée G (2016) Regulatory T cells delay disease progression in Alzheimer-like pathology. Brain 139(Pt 4):1237–1251. https://doi.org/10.1093/brain/awv408
Davanzo GG, Castro G, Monteiro LB, Castelucci BG, Jaccomo VH, da Silva FC, Marques AM, Francelin C, de Campos BB, de Aguiar CF, Joazeiro PP, Consonni SR, Farias ADS, Moraes-Vieira PM (2023) Obesity increases blood-brain barrier permeability and aggravates the mouse model of multiple sclerosis. Multiple Scler Relat Disorders 72:104605. https://doi.org/10.1016/j.msard.2023.104605
de Boer SA, Reijrink M, Abdulahad WH, Hoekstra ES, Slart R, Heerspink HJL, Westra J, Mulder DJ (2020) Angiogenic T cells are decreased in people with type 2 diabetes mellitus and recruited by the dipeptidyl peptidase-4 inhibitor linagliptin: a subanalysis from a randomized, placebo-controlled trial (RELEASE study). Diabetes Obes Metab 22(7):1220–1225. https://doi.org/10.1111/dom.14024
Article CAS PubMed PubMed Central Google Scholar
DeFuria J, Belkina AC, Jagannathan-Bogdan M, Snyder-Cappione J, Carr JD, Nersesova YR, Markham D, Strissel KJ, Watkins AA, Zhu M, Allen J, Bouchard J, Toraldo G, Jasuja R, Obin MS, McDonnell ME, Apovian C, Denis GV, Nikolajczyk BS (2013) B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile. Proc Natl Acad Sci USA 110(13):5133–5138. https://doi.org/10.1073/pnas.1215840110
留言 (0)