Meliambro K, He JC, Campbell KN. Podocyte-targeted therapies—progress and future directions. Nat Rev Nephrol. 2024. https://doi.org/10.1038/s41581-024-00843-z.
Boddu R, et al. Unique sex- and age-dependent effects in protective pathways in acute kidney injury. Am J Physiol Renal Physiol. 2017;313(3):F740–55.
Article CAS PubMed PubMed Central Google Scholar
Hosszu A, Fekete A, Szabo AJ. Sex differences in renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2020;319(2):F149–54.
Article CAS PubMed Google Scholar
Rinn JL, et al. Major molecular differences between mammalian sexes are involved in drug metabolism and renal function. Dev Cell. 2004;6(6):791–800.
Article CAS PubMed Google Scholar
Curtis LM. Sex and Gender Differences in AKI. Kidney360. 2024;5(1):160–7.
Carrero JJ, Hecking M, Chesnaye NC, Jager KJ. Sex and gender disparities in the epidemiology and outcomes of chronic kidney disease. Nat Rev Nephrol. 2018;14(3):151–64.
Chesnaye NC, Carrero JJ, Hecking M, Jager KJ. Differences in the epidemiology, management and outcomes of kidney disease in men and women. Nat Rev Nephrol. 2024;20(1):7–20.
Garcia GG, et al. Sex and gender differences in chronic kidney disease and access to care around the globe. Semin Nephrol. 2022;42(2):101–13.
Clotet-Freixas S, et al. Sex differences in kidney metabolism may reflect sex-dependent outcomes in human diabetic kidney disease. Sci Transl Med. 2024;16(737):eabm2090.
Article CAS PubMed Google Scholar
Mazure CM, Jones DP. Twenty years and still counting: including women as participants and studying sex and gender in biomedical research. BMC Womens Health. 2015;15:94.
Article PubMed PubMed Central Google Scholar
Bond KM, McCarthy MM, Rubin JB, Swanson KR. Molecular omics resources should require sex annotation: a call for action. Nat Methods. 2021;18(6):585–8.
Article CAS PubMed PubMed Central Google Scholar
NIH Policy on Sex as a Biological Variable. https://orwh.od.nih.gov/sex-gender/nih-policy-sex-biological-variable. Accessed 20 Nov 2022.
Our priorities-Gender and Diversity. https://www.scienceeurope.org/our-priorities/gender-and-diversity/. Accessed 15 Dec 2022.
Gender equality. https://ec.europa.eu/research/participants/docs/h2020-funding-guide/cross-cutting-issues/gender_en.htm. Accessed 20 Dec 2022.
Sex, gender and diversity in the life sciences. https://www.dfg.de/en/research_funding/principles_dfg_funding/diversity_dimensions/lw/index.html. Accessed 20 Dec 2022.
Bairey Merz CN, et al. Sex and the kidneys: current understanding and research opportunities. Nat Rev Nephrol. 2019;15(12):776–83.
Fantus D, Rogers NM, Grahammer F, Huber TB, Thomson AW. Roles of mTOR complexes in the kidney: implications for renal disease and transplantation. Nat Rev Nephrol. 2016;12(10):587–609.
Article CAS PubMed PubMed Central Google Scholar
Vollenbroker B, et al. mTOR regulates expression of slit diaphragm proteins and cytoskeleton structure in podocytes. Am J Physiol Renal Physiol. 2009;296(2):F418–26.
Zha D, Wu X. Nutrient sensing, signaling transduction, and autophagy in podocyte injury: implications for kidney disease. J Nephrol. 2023;36(1):17–29.
Puelles VG, et al. mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans. JCI Insight. 2019;4(18):e99271. https://insight.jci.org/articles/view/99271
Article PubMed PubMed Central Google Scholar
Ganesh SK, Subathra DC. Molecular and therapeutic insights of rapamycin: a multi-faceted drug from Streptomyces hygroscopicus. Mol Biol Rep. 2023;50(4):3815–33.
Article CAS PubMed PubMed Central Google Scholar
Weichhart T. mTOR as regulator of lifespan, aging, and cellular senescence: a mini-review. Gerontology. 2018;64(2):127–34.
Article CAS PubMed Google Scholar
Papadopoli D, et al. AmTOR as a central regulator of lifespan and aging. F1000Res. 2019;8:998.
Mota-Martorell N, Jove M, Pamplona R. mTOR complex 1 content and regulation is adapted to animal longevity. Int J Mol Sci. 2022;23(15):8747.
Article CAS PubMed PubMed Central Google Scholar
Lee DJW, Hodzic Kuerec A, Maier AB. Targeting ageing with rapamycin and its derivatives in humans: a systematic review. Lancet Healthy Longev. 2024;5(2):e152–62.
Sharp ZD, Strong R. Rapamycin, the only drug that has been consistently demonstrated to increase mammalian longevity. An update Exp Gerontol. 2023;176: 112166.
Article CAS PubMed Google Scholar
Juricic P, et al. Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy. Nat Aging. 2022;2(9):824–36.
Article CAS PubMed PubMed Central Google Scholar
Konopka AR, Lamming DW, Investigators RP, Investigators E. Blazing a trail for the clinical use of rapamycin as a geroprotecTOR. Geroscience. 2023;45(5):2769–83.
Article PubMed PubMed Central Google Scholar
Gurgen D, et al. Sex-specific mTOR signaling determines sexual dimorphism in myocardial adaptation in normotensive DOCA-salt model. Hypertension. 2013;61(3):730–6.
Gui Y, Dai C. mTOR signaling in kidney diseases. Kidney360. 2020;1(11):1319–27.
Article PubMed PubMed Central Google Scholar
Boerries M, et al. Molecular fingerprinting of the podocyte reveals novel gene and protein regulatory networks. Kidney Int. 2013;83(6):1052–64.
Article CAS PubMed Google Scholar
Percie du Sert N, et al. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PLoS Biol. 2020;18(7): e3000410.
Article CAS PubMed PubMed Central Google Scholar
Hohne M, et al. Single-nephron proteomes connect morphology and function in proteinuric kidney disease. Kidney Int. 2018;93(6):1308–19.
Dittmayer C, Volcker E, Wacker I, Schroder RR, Bachmann S. Modern field emission scanning electron microscopy provides new perspectives for imaging kidney ultrastructure. Kidney Int. 2018;94(3):625–31.
Fritsche-Guenther R, Bauer A, Gloaguen Y, Lorenz M, Kirwan JA. Modified protocol of harvesting, extraction, and normalization approaches for gas chromatography mass spectrometry-based metabolomics analysis of adherent cells grown under high fetal calf serum conditions. Metabolites. 2019;10(1):2.
留言 (0)