Polack, F. P. et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N. Engl. J. Med. 383, 2603–2615 (2020).
Article PubMed CAS Google Scholar
Baden, L. R. et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N. Engl. J. Med. 384, 403–416 (2020).
Wouters, O. J. et al. Challenges in ensuring global access to COVID-19 vaccines: production, affordability, allocation, and deployment. Lancet 397, 1023–1034 (2021).
Article PubMed PubMed Central CAS Google Scholar
Sarkar, I., Garg, R. & van Drunen Littel-van den Hurk, S. Selection of adjuvants for vaccines targeting specific pathogens. Expert Rev. Vaccines 18, 505–521 (2019).
Article PubMed PubMed Central CAS Google Scholar
Rossman, H. et al. COVID-19 dynamics after a national immunization program in Israel. Nat. Med. 27, 1055–1061 (2021).
Article PubMed CAS Google Scholar
Tartof, S. Y. et al. Effectiveness of mRNA BNT162b2 COVID-19 vaccine up to 6 months in a large integrated health system in the USA: a retrospective cohort study. Lancet 398, 1407–1416 (2021).
Article PubMed PubMed Central CAS Google Scholar
Pouwels, K. B. et al. Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK. Nat. Med. 21, 2127–2135 (2021).
Planas, D. et al. Considerable escape of SARS-CoV-2 Omicron to antibody neutralization. Nature 602, 671–675 (2021).
Khoury, D. S. et al. Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection. Nat. Med. 27, 1205–1211 (2021).
Article PubMed CAS Google Scholar
Wang, P. et al. Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7. Nature 593, 130–135 (2021).
Article PubMed CAS Google Scholar
Tarke, A. et al. Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals. Cell Rep. Med. 2, 100355 (2021).
Article PubMed PubMed Central CAS Google Scholar
Soresina, A. et al. Two X-linked agammaglobulinemia patients develop pneumonia as COVID-19 manifestation but recover. Pediatr. Allergy Immunol. 31, 565–569 (2020).
Article PubMed PubMed Central CAS Google Scholar
Tan, A. T. et al. Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients. Cell Rep. 34, 108728 (2021).
Article PubMed PubMed Central CAS Google Scholar
Kim, S.-H. & Jang, Y.-S. The development of mucosal vaccines for both mucosal and systemic immune induction and the roles played by adjuvants. Clin. Exp. Vaccin. Res. 6, 15–21 (2017).
Topol, E. J. & Iwasaki, A. Operation Nasal Vaccine—Lightning speed to counter COVID-19. Sci. Immunol. 0, eadd9947 (2022).
Counoupas, C. et al. Mucosal delivery of a multistage subunit vaccine promotes development of lung-resident memory T cells and affords interleukin-17-dependent protection against pulmonary tuberculosis. NPJ Vaccines 5, 105–105 (2020).
Article PubMed PubMed Central CAS Google Scholar
Ferrell, K. C. et al. Intrapulmonary vaccination with delta-inulin adjuvant stimulates non-polarised chemotactic signalling and diverse cellular interaction. Mucosal Immunol. 14, 762–773 (2021).
Article PubMed PubMed Central CAS Google Scholar
Lewis, D. J. et al. Transient facial nerve paralysis (Bell’s palsy) following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin. PLoS One 4, e6999 (2009).
Article PubMed PubMed Central Google Scholar
Minne, A. et al. The delivery site of a monovalent influenza vaccine within the respiratory tract impacts on the immune response. Immunology 122, 316–325 (2007).
Article PubMed PubMed Central CAS Google Scholar
Todoroff, J. et al. Targeting the deep lungs, Poloxamer 407 and a CpG oligonucleotide optimize immune responses to Mycobacterium tuberculosis antigen 85A following pulmonary delivery. Eur. J. Pharm. Biopharm. 84, 40–48 (2013).
Article PubMed CAS Google Scholar
Jeyanathan, M. et al. Aerosol delivery, but not intramuscular injection, of adenovirus-vectored tuberculosis vaccine induces respiratory-mucosal immunity in humans. JCI Insight 7, e155655 (2022).
Article PubMed PubMed Central Google Scholar
Cooper, P. D. & Petrovsky, N. Delta inulin: a novel, immunologically active, stable packing structure comprising β-D-[2 -> 1] poly(fructo-furanosyl) α-D-glucose polymers. Glycobiology 21, 595–606 (2011).
Article PubMed CAS Google Scholar
Kerekes, K. et al. Adjuvant effect of gamma-inulin is mediated by C3 fragments deposited on antigen-presenting cells. J. Leukoc. Biol. 69, 69–74 (2001).
Article PubMed CAS Google Scholar
Honda-Okubo, Y., Saade, F. & Petrovsky, N. Advax™, a polysaccharide adjuvant derived from delta inulin, provides improved influenza vaccine protection through broad-based enhancement of adaptive immune responses. Vaccine 30, 5373–5381 (2012).
Article PubMed PubMed Central CAS Google Scholar
Quan, D. H. et al. Advax adjuvant formulations promote protective immunity against aerosol Mycobacterium tuberculosis in the absence of deleterious inflammation and reactogenicity. Vaccine 39, 1990–1996 (2021).
Article PubMed CAS Google Scholar
Gordon, D. L. et al. Human Phase 1 trial of low-dose inactivated seasonal influenza vaccine formulated with Advax delta inulin adjuvant. Vaccine 34, 3780–3786 (2016).
Article PubMed PubMed Central CAS Google Scholar
Petrovsky, N. & Cooper, P. D. Advax™, a novel microcrystalline polysaccharide particle engineered from delta inulin, provides robust adjuvant potency together with tolerability and safety. Vaccine 33, 5920–5926 (2015).
Article PubMed PubMed Central CAS Google Scholar
Li, L. et al. Immunisation of ferrets and mice with recombinant SARS-CoV-2 spike protein formulated with Advax-SM adjuvant protects against COVID-19 infection. Vaccine 39, 5940–5953 (2021).
Article PubMed PubMed Central CAS Google Scholar
Li, L. et al. Covax-19/Spikogen® vaccine based on recombinant spike protein extracellular domain with Advax-CpG55.2 adjuvant provides single dose protection against SARS-CoV-2 infection in hamsters. Vaccine 40, 3182–3192 (2022).
Article PubMed PubMed Central CAS Google Scholar
Tabarsi, P. et al. Safety and immunogenicity of SpikoGen®, an Advax-CpG55.2-adjuvanted SARS-CoV-2 spike protein vaccine: a phase 2 randomized placebo-controlled trial in both seropositive and seronegative populations. Clin. Microbiol. Infect. 28, 1263–1271 (2022).
Article PubMed PubMed Central CAS Google Scholar
Tabarsi, P. et al. Immunogenicity and safety of SpikoGen®, an adjuvanted recombinant SARS-CoV-2 spike protein vaccine as a homologous and heterologous booster vaccination: a randomized placebo-controlled trial. Immunology 167, 340–353 (2022).
Article PubMed CAS Google Scholar
Zhuang, Z. et al. Mapping and role of T cell response in SARS-CoV-2-infected mice. J. Exp. Med. 218, e20202187 (2021).
Article PubMed PubMed Central CAS Google Scholar
Masopust, D. & Soerens, A. G. Tissue-resident T cells and other resident leukocytes. Annu. Rev. Immunol. 37, 521–546 (2019).
Article PubMed PubMed Central CAS Google Scholar
Zhao, J. et al. Airway memory CD4+ T cells mediate protective immunity against emerging respiratory coronaviruses. Immunity 44, 1379–1391 (2016).
Article PubMed PubMed Central CAS Google Scholar
Flórido, M. et al. Pulmonary immunization with a recombinant influenza A virus vaccine induces lung-resident CD4+ memory T cells that are associated with protection against tuberculosis. Mucosal Immunol. 11, 1743–1752 (2018).
Aegerter, H. et al. Influenza-induced monocyte-derived alveolar macrophages confer p
留言 (0)