Carvacrol alleviates LPS-induced myocardial dysfunction by inhibiting the TLR4/MyD88/NF-κB and NLRP3 inflammasome in cardiomyocytes

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T. JL Vincent, DC Angus. The Third International Consensus definitions for Sepsis and septic shock (Sepsis-3). JAMA. 2016;315:801–10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lv X, Wang H. Pathophysiology of sepsis-induced myocardial dysfunction. Mil Med Res. 2016;3:30.

PubMed  PubMed Central  Google Scholar 

Prescott HC, Angus DC. Enhancing recovery from Sepsis: a review. JAMA. 2018;319:62–75.

Article  PubMed  PubMed Central  Google Scholar 

Hollenberg SM, Singer M. Pathophysiology of sepsis-induced cardiomyopathy. Nat Rev Cardiol. 2021;18:424–34.

Article  PubMed  Google Scholar 

Lin Y, Xu Y, Zhang Z. Sepsis-Induced Myocardial Dysfunction (SIMD): the pathophysiological mechanisms and therapeutic strategies targeting Mitochondria. Inflammation. 2020;43:1184–200.

Article  CAS  PubMed  Google Scholar 

Khosrojerdi A, Soudi S, Hosseini AZ, Khaligh SG, Hashemi SM. The combination of mesenchymal stem cell- and hepatocyte-derived exosomes, along with imipenem, ameliorates inflammatory responses and liver damage in a sepsis mouse model. Life Sci. 2023;326:121813.

Article  CAS  PubMed  Google Scholar 

Avlas O, Fallach R, Shainberg A, Porat E, Hochhauser E. Toll-like receptor 4 stimulation initiates an inflammatory response that decreases cardiomyocyte contractility. Antioxid Redox Signal. 2011;15:1895–909.

Article  CAS  PubMed  Google Scholar 

Li N, Zhou H, Wu H, Wu Q, Duan M, Deng W, Tang Q. STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3. Redox Biol. 2019;24:101215.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maldonado RF, Sá-Correia I, Valvano MA. Lipopolysaccharide modification in Gram-negative bacteria during chronic infection. FEMS Microbiol Rev. 2016;40:480–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kuzmich NN, Sivak KV, Chubarev VN, Porozov YB, Savateeva-Lyubimova TN, Peri F. TLR4 signaling pathway modulators as potential therapeutics in inflammation and Sepsis. Vaccines (Basel). 2017;5.

Faria SS, Costantini S, de Lima VCC, de Andrade VP, Rialland M, Cedric R, Budillon A, Magalhães KG. NLRP3 inflammasome-mediated cytokine production and pyroptosis cell death in breast cancer. J Biomed Sci. 2021;28:26.

An N, Gao Y, Si Z, Zhang H, Wang L, Tian C, Yuan M, Yang X, Li X, Shang H, Xiong X, Xing Y. Regulatory mechanisms of the NLRP3 Inflammasome, a Novel Immune-inflammatory marker in Cardiovascular diseases. Front Immunol. 2019;10:1592.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dai S, Ye B, Chen L, Hong G, Zhao G, Lu Z. Emodin alleviates LPS-induced myocardial injury through inhibition of NLRP3 inflammasome activation. Phytother Res. 2021;35:5203–13.

Article  CAS  PubMed  Google Scholar 

Sharifi-Rad M, Varoni EM, Iriti M, Martorell M, Setzer WN, Del Mar M, Contreras B, Salehi A, Soltani-Nejad S, Rajabi M, Tajbakhsh J. Sharifi-Rad. Carvacrol and human health: a comprehensive review. Phytother Res. 2018;32:1675–87.

Article  CAS  PubMed  Google Scholar 

Boskabady MH, Alitaneh S, Alavinezhad A. Carum copticum L.: a herbal medicine with various pharmacological effects. Biomed Res Int. 2014;2014:569087.

Article  PubMed  PubMed Central  Google Scholar 

Suntres ZE, Coccimiglio J, Alipour M. The bioactivity and toxicological actions of carvacrol. Crit Rev Food Sci Nutr. 2015;55:304–18.

Article  CAS  PubMed  Google Scholar 

Khan F, Khan I, Farooqui A, Ansari IA. Carvacrol Induces Reactive Oxygen Species (ROS)-mediated apoptosis along with cell cycle arrest at G(0)/G(1) in human prostate Cancer cells. Nutr Cancer. 2017;69:1075–87.

Article  CAS  PubMed  Google Scholar 

Khan F, Singh VK, Saeed M, Kausar MA, Ansari IA. Carvacrol Induced Program Cell death and cell cycle arrest in androgen-independent human prostate Cancer cells via inhibition of Notch Signaling. Anticancer Agents Med Chem. 2019;19:1588–608.

Article  CAS  PubMed  Google Scholar 

Liu SD, Song MH, Yun W, Lee JH, Kim HB, Cho JH. Effect of carvacrol essential oils on immune response and inflammation-related genes expression in broilers challenged by lipopolysaccharide. Poult Sci. 2019;98:2026–33.

Article  CAS  PubMed  Google Scholar 

Guan X, Li X, Yang X, Yan J, Shi P, Ba L, Cao Y, Wang P. The neuroprotective effects of carvacrol on ischemia/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation. Life Sci. 2019;235:116795.

Article  CAS  PubMed  Google Scholar 

De Vincenzi M, Stammati A, De Vincenzi A, Silano M. Constituents of aromatic plants: carvacrol. Fitoterapia. 2004;75:801–4.

Article  PubMed  Google Scholar 

Zhao W, Deng C, Han Q, Xu H, Chen Y. Carvacrol may alleviate vascular inflammation in diabetic db/db mice. Int J Mol Med. 2020;46:977–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Ba L, Huang W, Liu Y, Pan H, Mingyao E, Shi P, Wang Y, Li S, Qi H, Sun H, Cao Y. Role of carvacrol in cardioprotection against myocardial ischemia/reperfusion injury in rats through activation of MAPK/ERK and Akt/eNOS signaling pathways. Eur J Pharmacol. 2017;796:90–100.

Article  CAS  PubMed  Google Scholar 

Yu W, Liu Q, Zhu S. Carvacrol protects against acute myocardial infarction of rats via anti-oxidative and anti-apoptotic pathways. Biol Pharm Bull. 2013;36:579–84.

Article  CAS  PubMed  Google Scholar 

Jafarinezhad Z, Rafati A, Ketabchi F, Noorafshan A, Karbalay-Doust S. Cardioprotective effects of curcumin and carvacrol in doxorubicin-treated rats: stereological study. Food Sci Nutr. 2019;7:3581–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

El-Sayed SM el, Mansour AM, Abdul-Hameed MS. Thymol and Carvacrol Prevent Doxorubicin-Induced cardiotoxicity by abrogation of oxidative stress, inflammation, and apoptosis in rats. J Biochem Mol Toxicol. 2016;30:37–44.

Marconi GD, Della Rocca Y, Fonticoli L, Guarnieri S, Carradori S, Rajan TS, Pizzicannella J, Diomede F. The Beneficial Effect of Carvacrol in HL-1 cardiomyocytes treated with LPS-G: anti-inflammatory pathway investigations. Antioxid (Basel). 2022;11.

Ning L, Rong J, Zhang Z, Xu Y. Therapeutic approaches targeting renin-angiotensin system in sepsis and its complications. Pharmacol Res. 2021;167:105409.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Liang X, Bao X, Xiao W, Chen G. Toll-like receptor 4 (TLR4) inhibitors: current research and prospective. Eur J Med Chem. 2022;235:114291.

Article  CAS  PubMed  Google Scholar 

Saljoughian S, Roohinejad S, Bekhit AEA, Greiner R, Omidizadeh A, Nikmaram N, Khaneghah AM. The effects of food essential oils on cardiovascular diseases: a review. Crit Rev Food Sci Nutr. 2018;58:1688–705.

Article  CAS  PubMed  Google Scholar 

Riaz M, Al Kury LT, Atzaz N, Alattar A, Alshaman R, Shah FA, Li S. Carvacrol alleviates Hyperuricemia-Induced oxidative stress and inflammation by modulating the NLRP3/NF-κB Pathwayt. Drug Des Devel Ther. 2022;16:1159–70.

Article  PubMed  PubMed Central  Google Scholar 

Wijesundara NM, Lee SF, Cheng Z, Davidson R, Rupasinghe HPV. Carvacrol exhibits rapid bactericidal activity against Streptococcus pyogenes through cell membrane damage. Sci Rep. 2021;11:1487.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wijesundara NM, Lee SF, Davidson R, Cheng Z, Rupasinghe HPV. Carvacrol suppresses inflammatory biomarkers production by Lipoteichoic Acid- and peptidoglycan-stimulated human tonsil epithelial cells. Nutrients. 2022;14.

Yan C, Kuang W, Jin L, Wang R, Niu L, Xie C, Ding J, Liao Y, Wang L, Wan H, Ma G. Carvacrol protects mice against LPS-induced sepsis and attenuates inflammatory response in macrophages by modulating the ERK1/2 pathway. Sci Rep. 2023;13:12809.

Article  CAS 

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