Xie J, Teng J, Fan Y, Xie R, Shen A. The short-term effects of air pollutants on hospitalizations for respiratory disease in Hefei. China Int J Biometeorol. 2019;63(3):315–26.
Yang Y, Li X, An X, Zhang L, Li X, Wang L, et al. Continuous exposure of PM2.5 exacerbates ovalbumin-induced asthma in mouse lung via a JAK-STAT6 signaling pathway. Adv Clin Exp Med. 2020;29(7):825–32.
Tiotiu AI, Novakova P, Nedeva D, Chong-Neto HJ, Novakova S, Steiropoulos P, et al. Impact of air pollution on asthma outcomes. MDPI AG. Int J Environ Res Public Health. 2020;17:1–29.
de Haar C, Hassing I, Bol M, Bleumink R, Pieters R. Ultrafine but not fine particulate matter causes airway inflammation and allergic airway sensitization to co-administered antigen in mice. Clin Exp Allergy. 2006;36(11):1469–79.
Zhao YX, Zhang HR, Yang XN, Zhang YH, Feng S, Yu FX, et al. Fine particulate matter-induced exacerbation of allergic asthma via activation of T-cell immunoglobulin and mucin domain 1. Chin Med J (Engl). 2018;131(20):2461–73.
Article CAS PubMed Google Scholar
Instituto Brasileiro de Geografia e Estatística. 2020. https://www.ibge.gov.br. Accessed in 7 Jul 2022.
Instituto Estadual de Meio Ambiente e Recursos Hídricos. Relatório de Qualidade do ar na Grande Vitória. 2019. https://iema.es.gov.br/Media/iema/CQAI/Relatorios_anuais/IEMA_CQAI_Relat%C3%B3rio_Anual_da_Qualidade_do_Ar_2019.pdf. Accessed 7 Jul 2022
Loriato AG, Salvador N, Loriato AAB, Sokolov A, Nascimento AP, Ynoue RY, et al. Inventário de Emissões com Alta Resolução para a Região da Grande Vitória Utilizando o Sistema de Modelagem Integrada WRF-SMOKE-CMAQ. Revista Brasileira de Meteorologia. 2018;33(3):521–36.
Galvão ES, Santos JM, Reis Junior NC, Feroni R de C, Orlando MTD. The mineralogical composition of coarse and fine particulate material, their fate, and sources in an industrialized region of southeastern Brazil. Environ Monit Assess. 2022;194(2):88.
Global Initiative for Asthma (GINA)-Main-Report-2021. Available from: https://ginasthma.org. Accessed in 6 Jul 2022.
dos Santos TM, Righetti RF, Rezende BG, Campos EC, Camargo L do N, Saraiva-Romanholo BM, et al. Effect of anti-IL17 and/or Rho-kinase inhibitor treatments on vascular remodeling induced by chronic allergic pulmonary inflammation. Ther Adv Respir Dis. 2020;14:1753466620962665.
Tiotiu AI, Novakova P, Nedeva D, Chong-Neto HJ, Novakova S, Steiropoulos P, et al. Impact of air pollution on asthma outcomes. Int J Environ Res Public Health. 2020;17(17):6212.
Article CAS PubMed PubMed Central Google Scholar
Inazu M. Functional expression of choline transporters in the blood-brain barrier. Nutrients. 2019;11(10):2265.
Article CAS PubMed PubMed Central Google Scholar
Lima R de F, Prado VF, Prado MAM, Kushmerick C. Quantal release of acetylcholine in mice with reduced levels of the vesicular acetylcholine transporter. J Neurochem. 2010;113(4):943–51.
Maouche K, Medjber K, Zahm JM, Delavoie F, Terryn C, Coraux C, et al. Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure. Proc Natl Acad Sci. 2013;110(10):4099–104.
Article CAS PubMed PubMed Central Google Scholar
Fujii T, Mashimo M, Moriwaki Y, Misawa H, Ono S, Horiguchi K, et al. Expression and function of the cholinergic system in immune cells. Front Immunol. 2017;6:8.
Racké K, Juergens UR, Matthiesen S. Control by cholinergic mechanisms. Eur J Pharmacol. 2006;533(1–3):57–68.
Kawashima K, Yoshikawa K, Fujii YX, Moriwaki Y, Misawa H. Expression and function of genes encoding cholinergic components in murine immune cells. Life Sci. 2007;80(24–25):2314–9.
Article CAS PubMed Google Scholar
Gosens R, Gross N. The mode of action of anticholinergics in asthma. Eur Respir J. 2018;52(4):1701247.
Article PubMed PubMed Central Google Scholar
Pinheiro NM, Miranda CJCP, Santana FR, Bittencourt-Mernak M, Arantes-Costa FM, Olivo C, et al. Effects of VAChT reduction and α7nAChR stimulation by PNU-282987 in lung inflammation in a model of chronic allergic airway inflammation. Eur J Pharmacol. 2020;5:882.
Pinheiro NM, Miranda CJCP, Perini A, Câmara NOS, Costa SKP, Alonso-Vale MIC, et al. Pulmonary inflammation is regulated by the levels of the vesicular acetylcholine transporter. PLoS ONE. 2015;10(3):e0120441.
Article PubMed PubMed Central Google Scholar
Prado VF, Martins-Silva C, de Castro BM, Lima RF, Barros DM, Amaral E, et al. Mice deficient for the vesicular acetylcholine transporter are myasthenic and have deficits in object and social recognition. Neuron. 2006;51(5):601–12.
Article CAS PubMed Google Scholar
Santana FPR, Pinheiro NM, Bittencourt-Mernak MI, Perini A, Yoshizaki K, Macchione M, et al. Vesicular acetylcholine transport deficiency potentiates some inflammatory responses induced by diesel exhaust particles. Ecotoxicol Environ Saf. 2019;167:494–504.
Article CAS PubMed Google Scholar
Hopke PK, Xie Y, Raunemaa T, Biegalski S, Landsberger S, Maenhaut W, et al. Characterization of the gent stacked filter unit PM 10 sampler. Aerosol Sci Technol. 1997;27(6):726–35.
de Miranda RM, de Fatima Andrade M, Fornaro A, Astolfo R, de Andre PA, Saldiva P. Urban air pollution: a representative survey of PM2.5 mass concentrations in six Brazilian cities. Air Qual Atmos Health. 2012;5(1):63–77.
Prado CM, Leick-Maldonado EA, Arata V, Kasahara DI, Martins MA, Tibério IFLC. Neurokinins and inflammatory cell iNOS expression in guinea pigs with chronic allergic airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2005;288(4):L741–8.
Article CAS PubMed Google Scholar
Leick-maldonado EA, Kay FU, Leonhardt MC, Kasahara DI, Prado CM, Fernandes FT, et al. Comparison of glucocorticoid and cysteinyl leukotriene receptor antagonist treatments in an experimental model of chronic airway inflammation in guinea-pigs. Clin Exp Allergy. 2004;34(1):145–52.
Article CAS PubMed Google Scholar
Hantos Z, Daroczy B, Suki B, Nagy S, Fredberg JJ. Input impedance and peripheral inhomogeneity of dog lungs. J Appl Physiol. 1992;72(1):168–78.
Article CAS PubMed Google Scholar
Martins-Olivera BT, Almeida-Reis R, Theodoro-Júnior OA, Oliva LV, Neto dos Santos Nunes N, Olivo CR, et al. The plantderived Bauhinia bauhinioides kallikrein proteinase inhibitor (rBbKI) attenuates elastase-induced emphysema in mice. Mediators Inflamm. 2016:1–12.
Santos TM dos, Righetti RF, Camargo L do N, Saraiva-Romanholo BM, Aristoteles LRCRB, de Souza FCR, et al. Effect of Anti-IL17 Antibody Treatment Alone and in Combination With Rho-Kinase Inhibitor in a Murine Model of Asthma. Front Physiol. 2018;9:1183.
Camargo L, Righetti RF, Aristóteles LRCRB, Santos TM, Souza FCR, Fukuzaki S, et al. Effects of anti-IL17 on inflammation, remodeling, and oxidative stress in an experimental model of asthma exacerbated by LPS. In: Airway Cell Biology and Immunopathology. European Respiratory Society; 2018. p. PA983.
Righetti RF, Pigati PA da S, Possa SS, Habrum FC, Xisto DG, Antunes MA, et al. Effects of Rho-kinase inhibition in lung tissue with chronic inflammation. Respir Physiol Neurobiol. 2014;192:134–46.
Article CAS PubMed Google Scholar
Santana FPR, Ricardo-da-Silva FY, Fantozzi ET, Pinheiro NM, Tibério IFLC, Moreira LFP, et al. Lung edema and mortality induced by intestinal ischemia and reperfusion is regulated by VAChT Levels in female mice. Inflammation. 2021;44(4):1553–64.
Article CAS PubMed Google Scholar
Pinheiro NM, Banzato R, Tibério I, Prado MAM, Prado VF, Hamouda AK, et al. Acute lung injury in cholinergic-deficient mice supports anti-inflammatory role of α7 nicotinic acetylcholine receptor. Int J Mol Sci. 2021;22(14):7552.
Bezemer GFG, Bauer SM, Oberdörster G, Breysse PN, Pieters RHH, Georas SN, et al. Activation of pulmonary dendritic cells and th2-type inflammatory responses on instillation of engineered, environmental diesel emission source or ambient air pollutant particles in vivo. J Innate Immun. 2011;3(2):150–66.
Article CAS PubMed Google Scholar
Glencross DA, Ho TR, Camiña N, Hawrylowicz CM, Pfeffer PE. Air pollution and its effects on the immune system. Free Radic Biol Med. 2020;151:56–68.
Article CAS PubMed Google Scholar
Gour N, Sudini K, Khalil SM, Rule AM, Lees P, Gabrielson E, et al. Unique pulmonary immunotoxicological effects of urban PM are not recapitulated solely by carbon black, diesel exhaust or coal fly ash. Environ Res. 2018;161:304–13.
Article CAS PubMed Google Scholar
Huang KL, Liu SY, Chou CCK, Lee YH, Cheng TJ. The effect of size-segregated ambient particulate matter on Th1/Th2-like immune responses in mice. PLoS ONE. 2017;12(2):e0173158.
Article PubMed PubMed Central Google Scholar
Gori S, Vermeulen M, Remes-Lenicov F, Jancic C, Scordo W, Ceballos A, et al. Acetylcholine polarizes dendritic cells toward a Th2-promoting profile. Allergy. 2017;72(2):221–31.
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