Hu Q, Ren H, Ren J, Liu Q, Wu J, Wu X, Li G, Wang G, Gu G, Guo K, et al. Released Mitochondrial DNA Following Intestinal Ischemia Reperfusion Induces the Inflammatory Response and Gut Barrier Dysfunction. Sci Rep. 2018;8(1):7350.

Article  PubMed  PubMed Central  Google Scholar 

Wong YL, Lautenschlager I, Hummitzsch L, Zitta K, Cossais F, Wedel T, Rusch R, Berndt R, Gruenewald M, Weiler N, et al. Effects of different ischemic preconditioning strategies on physiological and cellular mecha-nisms of intestinal ischemia/reperfusion injury: Implication from an isolated perfused rat small intestine model. PLoS ONE. 2021;16(9): e0256957.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li G, Wang S, Fan Z. Oxidative Stress in Intestinal Ischemia-Reperfusion. Front Med (Lausanne). 2021;8: 750731.

Article  PubMed  Google Scholar 

Gharishvandi F, Abdollahi A, Shafaroodi H, Mohammad Jafari R, Pasalar P, Dehpour AR. Involvement of 5-HT1B/1D receptors in the inflammatory response and oxidative stress in intestinal ischemia/reperfusion in rats. Eur J Pharmacol. 2020;882: 173265.

Article  CAS  PubMed  Google Scholar 

Jin C, Fu WL, Zhang DD, Xing WW, Xia WR, Wei Z, Zou MJ, Zhu XM, Xu DG. The protective role of IL-1Ra on intestinal ischemia reperfusion injury by anti-oxidative stress via Nrf2/HO-1 pathway in rat. Biomed J. 2019;42(1):36–45.

Article  PubMed  PubMed Central  Google Scholar 

Wang P, Cui Y, Liu Y, Li Z, Bai H, Zhao Y, Chang YZ. Mitochondrial ferritin alleviates apoptosis by enhancing mitochondrial bioenergetics and stimulating glucose metabolism in cerebral ischemia reperfusion. Redox Biol. 2022;57: 102475.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miyake H, Koike Y, Seo S, Lee C, Li B, Ganji N, Pierro A. The effect of pre- and post-remote ischemic conditioning reduces the injury associated with intestinal ischemia/reperfusion. Pediatr Surg Int. 2020;36(12):1437–42.

Article  PubMed  Google Scholar 

Ucar BI, Ucar G, Saha S, Buttari B, Profumo E, Saso L. Pharmacological Protection against Ische-mia-Reperfusion Injury by Regulating the Nrf2-Keap1-ARE Signaling Pathway. Antioxidants (Basel). 2021;10(6):823.

Article  CAS  PubMed  Google Scholar 

Li G, Zhang Y, Fan Z. Cellular Signal Transduction Pathways Involved in Acute Lung Injury Induced by Intestinal Ischemia-Reperfusion. Oxid Med Cell Longev. 2021;2021:9985701.

PubMed  PubMed Central  Google Scholar 

Sharifi-Rad J, Herrera-Bravo J, Kamiloglu S, Petroni K, Mishra AP, Monserrat-Mesquida M, Sureda A, Martorell M, Aidarbekovna DS, Yessimsiitova Z, et al. Recent advances in the therapeutic potential of emodin for human health. Biomed Pharmacother. 2022;154: 113555.

Article  CAS  PubMed  Google Scholar 

Xing M, Ma X, Wang X, Wang H, Xie M, Zhang Z, Zhou J. Emodin disrupts the Notch1/Nrf2/GPX4 antioxidant system and promotes renal cell ferroptosis. J Appl Toxicol. 2023;43(11):1702–18.

Article  CAS  PubMed  Google Scholar 

Dong X, Fu J, Yin X, Cao S, Li X, Lin L. Huyiligeqi, Ni J: Emodin: A Review of its Pharmacology. Toxicity and Pharmacokinetics Phytother Res. 2016;30(8):1207–18.

Article  CAS  PubMed  Google Scholar 

Leung SW, Lai JH, Wu JC, Tsai YR, Chen YH, Kang SJ, Chiang YH, Chang CF, Chen KY. Neuroprotective Effects of Emodin against Ischemia/Reperfusion Injury through Activating ERK-1/2 Signaling Pathway. Int J Mol Sci. 2020;21(8):2899.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chao HW, Chen YK, Liu JH, Pan HT, Lin HM, Chao HM. Emodin protected against retinal ischemia insulted neurons through the downregulation of protein overexpression of beta-catenin and vascular endothelium factor. BMC Complement Med Ther. 2020;20(1):338.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qian J, Li G, Jin X, Ma C, Cai W, Jiang N, Zheng J. Emodin protects against intestinal and lung injury induced by acute intestinal injury by modulating SP-A and TLR4/NF-kappaB pathway. Biosci Rep. 2020;40(9):BSR20201605.

Article  PubMed  PubMed Central  Google Scholar 

Shariati M, Meric-Bernstam F. Targeting AKT for cancer therapy. Expert Opin Investig Drugs. 2019;28(11):977–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang M, Zhang J, Gong N. Role of the PI3K/Akt signaling pathway in liver ischemia reperfusion injury: a narrative review. Ann Palliat Med. 2022;11(2):806–17.

Article  CAS  PubMed  Google Scholar 

Liu C, Chen K, Wang H, Zhang Y, Duan X, Xue Y, He H, Huang Y, Chen Z, Ren H, et al. Gastrin Attenuates Renal Ischemia/Reperfusion Injury by a PI3K/Akt/Bad-Mediated Anti-apoptosis Signaling. Front Pharmacol. 2020;11: 540479.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zou Z, Wang Z. Liraglutide attenuates intestinal ischemia/reperfusion injury via NF-kappaB and PI3K/Akt pathways in mice. Life Sci. 2022;309: 121045.

Article  CAS  PubMed  Google Scholar 

Chen R, Zhang YY, Lan JN, Liu HM, Li W, Wu Y, Leng Y, Tang LH, Hou JB, Sun Q, et al. Ischemic Post-conditioning Alleviates Intestinal Ischemia-Reperfusion Injury by Enhancing Autophagy and Suppressing Oxidative Stress through the Akt/GSK-3beta/Nrf2 Pathway in Mice. Oxid Med Cell Longev. 2020;2020:6954764.

PubMed  PubMed Central  Google Scholar 

Ryter SW. Heme oxygenase-1 /carbon monoxide as modulators of autophagy and inflammation. Arch Bio-chem Biophys. 2019;678: 108186.

Article  CAS  Google Scholar 

Tebay LE, Robertson H, Durant ST, Vitale SR, Penning TM, Dinkova-Kostova AT, Hayes JD. Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease. Free Radic Biol Med. 2015;88(Pt B):108–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sougiannis AT, Enos RT, VanderVeen BN, Velazquez KT, Kelly B, McDonald S, Cotham W, Chatzistamou I, Nagarkatti M, Fan D, et al. Safety of natural anthraquinone emodin: an assessment in mice. BMC Pharmacol Toxicol. 2021;22(1):9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arosio B, Gagliano N, Fusaro LMP, Parmeggiani L, Tagliabue J, Galetti P, De Castri D, Moscheni C, Annoni G. Aloe-Emodin Quinone Pretreatment Reduces Acute Liver Injury Induced by Carbon Tetrachloride. Pharmacol Toxicol. 2008;87(5):229–33.

Article  Google Scholar 

Lai C, Chen Q, Ding Y, Liu H, Tang Z. Emodin protected against synaptic impairment and oxidative stress induced by fluoride in SH-SY5Y cells by modulating ERK1/2/Nrf2/HO-1 pathway. Environ Toxicol. 2020;35(9):922–9.

Article  CAS  PubMed  Google Scholar 

Wang X, Yang S, Li Y, Jin X, Lu J, Wu M. Role of emodin in atherosclerosis and other cardiovascular diseases: Pharmacological effects, mechanisms, and potential therapeutic target as a phytochemical. Biomed Phar-macother. 2023;161: 114539.

Article  CAS  Google Scholar 

Chiu Chu-Jeng, McArdle AH, Brown Rea, et al. Intestinal Mucosal Lesion in Low-Flow States I. A Morphological, Hemodynamic, and Metabolic Reappraisal. Arch Surg. 1970;101(4):478–83.

Article  CAS  PubMed  Google Scholar 

Santana FPR, Ricardo-da-Silva FY, Fantozzi ET, Pinheiro NM, Tiberio I, Moreira LFP, Prado MAM, Prado VF, Tavares-de-Lima W, Prado CM, et al. Lung Edema and Mortality Induced by Intestinal Ischemia and Reperfusion Is Regulated by VAChT Levels in Female Mice. Inflammation. 2021;44(4):1553–64.

Article  CAS  PubMed  Google Scholar 

Bala M, Catena F, Kashuk J, De Simone B, Gomes CA, Weber D, Sartelli M, Coccolini F, Kluger Y, Abu-Zidan FM, et al. Acute mesenteric ischemia: updated guidelines of the World Society of Emergency Surgery. World J Emerg Surg. 2022;17(1):54.

Article  PubMed  PubMed Central