Alterations of the IKZF1-IKZF2 tandem in immune cells of schizophrenia patients regulate associated phenotypes

Aguilar R, Campo JJ, Chicuecue S, Cisteró P, Català A, Luis L, Ubillos I, Galatas B, Aide P, Guinovart C, Moncunill G, Dobaño C. Changing plasma cytokine, chemokine and growth factor profiles upon differing malaria transmission intensities. Malar J. 2019;18:406. https://doi.org/10.1186/s12936-019-3038-x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahmad SF, Nadeem A, Ansari MA, Bakheet SA, AL-Ayadhi LY, Attia SM. Downregulation in Helios transcription factor signaling is associated with immune dysfunction in blood leukocytes of autistic children. Prog Neuro-Psychopharmacol Biol Psychiatry. 2018;85:98–104. https://doi.org/10.1016/j.pnpbp.2018.04.011.

Article  CAS  Google Scholar 

Alberro A, Iparraguirre L, Fernandes A, Otaegui D. Extracellular vesicles in blood: sources, effects, and applications. Int J Mol Sci. 2021;22:8163. https://doi.org/10.3390/ijms22158163.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alhosaini K, Ansari MA, Nadeem A, Attia SM, Bakheet SA, Al-Ayadhi LY, Mahmood HM, Al-Mazroua HA, Ahmad SF. Dysregulation of Ki-67 expression in T cells of children with autism spectrum disorder. Children. 2021;8:116. https://doi.org/10.3390/children8020116.

Article  PubMed  PubMed Central  Google Scholar 

Alsiö JM, Tarchini B, Cayouette M, Livesey FJ. Ikaros promotes early-born neuronal fates in the cerebral cortex. Proc Natl Acad Sci. 2013. https://doi.org/10.1073/pnas.1215707110.

Article  PubMed  PubMed Central  Google Scholar 

Ballasch I, García-García E, Vila C, Pérez-González A, Sancho-Balsells A, Fernández J, Soto D, Puigdellívol M, Gasull X, Alberch J, Rodríguez MJ, Canals JM, Giralt A. Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration. Brain Behav Immun. 2023;109:144–61. https://doi.org/10.1016/j.bbi.2023.01.016.

Article  CAS  PubMed  Google Scholar 

Brito V, Montalban E, Sancho-Balsells A, Pupak A, Flotta F, Masana M, Ginés S, Alberch J, Martin C, Girault J-A, Giralt A. Hippocampal Egr1 -dependent neuronal ensembles negatively regulate motor learning. J Neurosci. 2022;42:5346–60. https://doi.org/10.1523/JNEUROSCI.2258-21.2022.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brombacher TM, Berkiks I, Pillay S, Scibiorek M, Moses BO, Brombacher F. IL-4R alpha deficiency influences hippocampal-BDNF signaling pathway to impair reference memory. Sci Rep. 2020;10:16506. https://doi.org/10.1038/s41598-020-73574-3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Busse S, Busse M, Schiltz K, Bielau H, Gos T, Brisch R, Mawrin C, Schmitt A, Jordan W, Müller UJ, Bernstein H-G, Bogerts B, Steiner J. Different distribution patterns of lymphocytes and microglia in the hippocampus of patients with residual versus paranoid schizophrenia: further evidence for disease course-related immune alterations? Brain Behav Immun. 2012;26:1273–9. https://doi.org/10.1016/j.bbi.2012.08.005.

Article  CAS  PubMed  Google Scholar 

Cai Q, Dierich A, Oulad-Abdelghani M, Chan S, Kastner P. Helios deficiency has minimal impact on T cell development and function. J Immunol. 2009;183:2303–11. https://doi.org/10.4049/jimmunol.0901407.

Article  CAS  PubMed  Google Scholar 

Cattane N, Minelli A, Milanesi E, Maj C, Bignotti S, Bortolomasi M, Chiavetto LB, Gennarelli M. Altered gene expression in schizophrenia: findings from transcriptional signatures in fibroblasts and blood. PLoS ONE. 2015;10: e0116686. https://doi.org/10.1371/journal.pone.0116686.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chaudhry IB, Husain MO, Khoso AB, Husain MI, Buch MH, Kiran T, Fu B, Bassett P, Qurashi I, ur Rahman R, Baig S, Kazmi A, Corsi-Zuelli F, Haddad PM, Deakin B, Husain N. A randomised clinical trial of methotrexate points to possible efficacy and adaptive immune dysfunction in psychosis. Transl Psychiatry. 2020;10:415. https://doi.org/10.1038/s41398-020-01095-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cho J, Nelson TE, Bajova H, Gruol DL. Chronic CXCL10 alters neuronal properties in rat hippocampal culture. J Neuroimmunol. 2009;207:92–100. https://doi.org/10.1016/j.jneuroim.2008.12.007.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Consortium A.W.G. of T.P.G. Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. Mol Autism. 2017;8:21. https://doi.org/10.1186/s13229-017-0137-9.

Article  CAS  Google Scholar 

Corsi-Zuelli F, Deakin B, de Lima MHF, Qureshi O, Barnes NM, Upthegrove R, Louzada-Junior P, Del-Ben CM. T regulatory cells as a potential therapeutic target in psychosis? Current challenges and future perspectives. Brain Behav Immun Heal. 2021;17:100330. https://doi.org/10.1016/j.bbih.2021.100330.

Article  CAS  Google Scholar 

Craddock RM, Lockstone HE, Rider DA, Wayland MT, Harris LJW, McKenna PJ, Bahn S. Altered T-cell function in schizophrenia: a cellular model to investigate molecular disease mechanisms. PLoS ONE. 2007;2: e692. https://doi.org/10.1371/journal.pone.0000692.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davis J, Eyre H, Jacka FN, Dodd S, Dean O, McEwen S, Debnath M, McGrath J, Maes M, Amminger P, McGorry PD, Pantelis C, Berk M. A review of vulnerability and risks for schizophrenia: beyond the two hit hypothesis. Neurosci Biobehav Rev. 2016;65:185–94. https://doi.org/10.1016/j.neubiorev.2016.03.017.

Article  PubMed  PubMed Central  Google Scholar 

de Pins B, Cifuentes-Díaz C, Thamila Farah A, López-Molina L, Montalban E, Sancho-Balsells A, López A, Ginés S, Delgado-García JM, Alberch J, Gruart A, Girault J-A, Giralt A. Conditional BDNF delivery from astrocytes rescues memory deficits, spine density and synaptic properties in the 5xFAD mouse model of Alzheimer disease. J Neurosci. 2019. https://doi.org/10.1523/JNEUROSCI.2121-18.2019.

Article  PubMed  PubMed Central  Google Scholar 

Domenici E, Willé DR, Tozzi F, Prokopenko I, Miller S, McKeown A, Brittain C, Rujescu D, Giegling I, Turck CW, Holsboer F, Bullmore ET, Middleton L, Merlo-Pich E, Alexander RC, Muglia P. Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collections. PLoS ONE. 2010;5: e9166. https://doi.org/10.1371/journal.pone.0009166.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ermakov EA, Melamud MM, Buneva VN, Ivanova SA. Immune system abnormalities in schizophrenia: an integrative view and translational perspectives. Front Psychiatry. 2022. https://doi.org/10.3389/fpsyt.2022.880568.

Article  PubMed  PubMed Central  Google Scholar 

Fila-Danilow A, Kucia K, Kowalczyk M, Owczarek A, Paul-Samojedny M, Borkowska P, Suchanek R, Kowalski J. Association study of interleukin-4 polymorphisms with paranoid schizophrenia in the Polish population: a critical approach. Mol Biol Rep. 2012;39:7941–7. https://doi.org/10.1007/s11033-012-1639-3.

Article  CAS  PubMed  Google Scholar 

Frydecka D, Krzystek-Korpacka M, Lubeiro A, Stramecki F, Stańczykiewicz B, Beszłej JA, Piotrowski P, Kotowicz K, Szewczuk-Bogusławska M, Pawlak-Adamska E, Misiak B. Profiling inflammatory signatures of schizophrenia: a cross-sectional and meta-analysis study. Brain Behav Immun. 2018;71:28–36. https://doi.org/10.1016/j.bbi.2018.05.002.

Article  PubMed  Google Scholar 

Furney SJ, Simmons A, Breen G, Pedroso I, Lunnon K, Proitsi P, Hodges A, Powell J, Wahlund L-O, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Spenger C, Lathrop M, Shen L, Kim S, Saykin AJ, Weiner MW, Lovestone S. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer’s disease. Mol Psychiatry. 2011;16:1130–8. https://doi.org/10.1038/mp.2010.123.

Article  CAS  PubMed  Google Scholar 

Gadani SP, Cronk JC, Norris GT, Kipnis J. IL-4 in the brain: a cytokine to remember. J Immunol. 2012;189:4213–9. https://doi.org/10.4049/jimmunol.1202246.

Article  CAS  PubMed  Google Scholar 

Gao Y, Li J, Cai G, Wang Y, Yang W, Li Y, Zhao X, Li R, Gao Y, Tuo W, Baldwin RL, Li C, Fang L, Liu GE. Single-cell transcriptomic and chromatin accessibility analyses of dairy cattle peripheral blood mononuclear cells and their responses to lipopolysaccharide. BMC Genom. 2022;23:338. https://doi.org/10.1186/s12864-022-08562-0.

Article  CAS 

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