aDivision of General Medicine, Columbia University, New York, New York

bDepartment of Cardiology, Boston Children's Hospital

cDepartment of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA

Correspondence to Yiyi Zhang, PhD, Columbia University Medical Center, Division of General Medicine, 622 W. 168th Street, PH9-109A, New York, NY 10032, USA. Tel: +1 212 305 6787; fax: +1 212 305 9349; e-mail: [email protected]