Ackerman SD, Garcia C, Piao X, Gutmann DH, Monk KR (2015) The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA. Nat Commun 6:6122

Article  CAS  PubMed  Google Scholar 

Afik R, Zigmond E, Vugman M, Klepfish M, Shimshoni E, Pasmanik-Chor M, Varol C (2016) Tumor macrophages are pivotal constructors of tumor collagenous matrix. J Exp Med 213:2315–2331

Article  CAS  PubMed  PubMed Central  Google Scholar 

Akimov SS, Krylov D, Fleischmana LF, Belkin AM (2000) Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin. J Cell Biol 148:825–838

Article  CAS  PubMed  PubMed Central  Google Scholar 

Al Hasan M, Roy P, Dolan S, Martin PE, Patterson S, Bartholomew C (2020) Adhesion G-protein coupled receptor 56 is required for 3T3-L1 adipogenesis. J Cell Physiol 235:1601–1614

Article  CAS  PubMed  Google Scholar 

Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (2012) A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis. EMBO J 31:1364–1378

Article  PubMed  PubMed Central  Google Scholar 

Belkin AM (2011) Extracellular TG2: emerging functions and regulation. FEBS J 278:4704–4716

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bianconi D, Unseld M, Prager G (2016) Integrins in the spotlight of cancer. Int J Mol Sci 17:2037

Article  PubMed  PubMed Central  Google Scholar 

Bilemjian V, Vlaming MR, Álvarez Freile J, Huls G, De Bruyn M, Bremer E (2022) The novel immune checkpoint GPR56 is expressed on tumor-infiltrating lymphocytes and selectively upregulated upon TCR signaling. Cancers (basel) 14:3164

Article  CAS  PubMed  Google Scholar 

Bornstein P (2009) Matricellular proteins: An overview J Cell Commun Signal 3:163–165.

Cawston TE, and Young DA (2010) Proteinases involved in matrix turnover during cartilage and bone breakdown. Cell Tissue Res 339:221–35.

Chigurupati S, Venkataraman R, Barrera D, Naganathan A, Madan M, Paul L, Chan SL (2010) Receptor channel TRPC6 is a key mediator of Notch-driven glioblastoma growth and invasiveness. Cancer Res 70:418–427

Article  CAS  PubMed  Google Scholar 

Condello S, Prasad M, Atwani R, Matei D (2022) Tissue transglutaminase activates integrin-linked kinase and β-catenin in ovarian cancer. J Biol Chem 298:102242

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dardik R, Inbal A (2006) Complex formation between tissue transglutaminase II (tTG) and vascular endothelial growth factor receptor 2 (VEGFR-2): proposed mechanism for modulation of endothelial cell response to VEGF. Exp Cell Res 312:2973–2982

Article  CAS  PubMed  Google Scholar 

Eckert RL (2019) Transglutaminase 2 takes center stage as a cancer cell survival factor and therapy target. Mol Carcinog 58:837–853

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eckert RL, Kaartinen MT, Nurminskaya M, Belkin AM, Colak G, Johnson GVW, Mehta K (2014) Transglutaminase regulation of cell function. Physiol Rev 94:383–417

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elvidge GP, Glenny L, Appelhoff RJ, Ratcliffe PJ, Ragoussis J, Gleadle JM (2006) Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1α, HIF-2α, and other pathways. J Biol Chem 281:15215–15226

Article  CAS  PubMed  Google Scholar 

Ganesh RA, Sonpatki P, Naik D, John AE, Sathe G, Lakshmikantha A, Sirdeshmukh R (2022) Multi-omics analysis of glioblastoma and glioblastoma cell line: molecular insights into the functional role of GPR56 and TG2 in mesenchymal transition. Front Oncol 12:841890

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ganesh RA, Venkataraman K, Sirdeshmukh R (2020) GPR56: an adhesion GPCR involved in brain development, neurological disorders and cancer. Brain Res 1747:147055

Article  CAS  PubMed  Google Scholar 

Hamada K, Terauchi A, Nakamura K, Higo T, Nukina N, Matsumoto N, Mikoshiba K (2014) Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors. Proc Natl Acad Sci U S A 111:E3966–E3975

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han M-S, Jung Y-K, Kim G-W, Han S (2020) Transglutaminase-2 regulates Wnt and FoxO3a signaling to determine the severity of osteoarthritis. Sci Rep 10:13228

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jechlinger M, Sommer A, Moriggl R, Seither P, Kraut N, Capodiecci P, Grünert S (2006) Autocrine PDGFR signaling promotes mammary cancer metastasis. J Clin Invest 116:1561–1570

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jeong SJ, Luo R, Singer K, Giera S, Kreidberg J, Kiyozumi D, Piao X (2013) GPR56 functions together with α3β1 integrin in regulating cerebral cortical development. PLoS ONE 8:1–9

Article  Google Scholar 

Joseph JV, Conroy S, Pavlov K, Sontakke P, Tomar T, Eggens-Meijer E, Kruyt FAE (2015) Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α–ZEB1 axis. Cancer Lett 359:107–116

Article  CAS  PubMed  Google Scholar 

Kandasamy K, Mohan S, Raju R, Keerthikumar S, Kumar GSS, Venugopal AK, Pandey A (2010) NetPath: a public resource of curated signal transduction pathways. Genome Biol 11, R3.

Kang SS, Han KS, Ku BM, Lee YK, Hong J, Shin HY, Lee CJ (2010) Caffeine-mediated inhibition of calcium release channel inositol 1,4,5-trisphosphate receptor subtype 3 blocks glioblastoma invasion and extends survival. Cancer Res 70:1173–1183

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ke N, Ma H, Diedrich G, Chionis J, Liu G, Yu D-H, Li Q-X (2008) Biochemical characterization of genetic mutations of GPR56 in patients with bilateral frontoparietal polymicrogyria (BFPP). Biochem Biophys Res Commun 366:314–320

Article  CAS  PubMed  Google Scholar 

Ke N, Sundaram R, Liu G, Chionis J, Fan W, Rogers C, Li QX (2007) Orphan G protein-coupled receptor GPR56 plays a role in cell transformation and tumorigenesis involving the cell adhesion pathway. Mol Cancer Ther 6:1840–1850

Article  CAS  PubMed  Google Scholar 

Kim H-J, Litzenburger BC, Cui X, Delgado DA, Grabiner BC, Lin X, Lee AV (2007) Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-κB and Snail. Mol Cell Biol 27:3165–3175

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim JE, Han JM, Park CR, Shin KJ, Ahn C, Seong JY, Hwang JI (2010) Splicing variants of the orphan G-protein-coupled receptor GPR56 regulate the activity of transcription factors associated with tumorigenesis. J Cancer Res Clin Oncol 136:47–53

Article  CAS  PubMed  Google Scholar 

Kutmon M, van Iersel MP, Bohler A, Kelder T, Nunes N, Pico AR, and Evelo CT (2015) PathVisio 3: An Extendable Pathway Analysis Toolbox PLoS. Comput Biol 11:1–13.

Langenhan T, Piao X, Monk KR (2016) Adhesion G protein-coupled receptors in nervous system development and disease. Nat Rev Neurosci 17:550–561

Article  CAS  PubMed  Google Scholar 

Leclerc C, Haeich J, Aulestia FJ, Kilhoffer M-C, Miller AL, Néant I, Moreau M (2016) Calcium signaling orchestrates glioblastoma development: facts and conjunctures. Biochim Biophys Acta 1863:1447–1459

Article  CAS  PubMed  Google Scholar 

Lee Y, Lee JK, Ahn SH, Lee J, Nam DH (2016) WNT signaling in glioblastoma and therapeutic opportunities. Lab Investig 96:137–150

Article  CAS  PubMed  Google Scholar 

Luo R, Jin Z, Deng Y, Strokes N, Piao X (2012) Disease-associated mutations prevent GPR56-collagen III interaction. PLoS ONE 7:1–7

Google Scholar 

Maina EN, Morris MR, Zatyka M, Raval RR, Banks RE, Richards FM, Maher ER (2005) Identification of novel VHL target genes and relationship to hypoxic response pathways. Oncogene 24:4549–4558

Article  CAS  PubMed  Google Scholar 

Malric L, Monferran S, Gilhodes J, Boyrie S, Dahan P, Skuli N, Lemarié A (2017) Interest of integrins targeting in glioblastoma according to tumor heterogeneity and cancer stem cell paradigm: an update. Oncotarget 8:86947–86968

Article  PubMed  PubMed Central  Google Scholar 

Millar MW, Corson N, Xu L (2018) The adhesion G-protein-coupled receptor, GPR56/ADGRG1, inhibits cell-extracellular matrix signaling to prevent metastatic melanoma growth. Front Oncol 8:1–14

Article  Google Scholar 

Moreno M, Pedrosa L, Paré L, Pineda E, Bejarano L, Martínez J, de la Iglesia N (2017) GPR56/ADGRG1 Inhibits Mesenchymal Differentiation and Radioresistance in Glioblastoma Cell Rep 21:2183–2197

Motaln H, Turnsek T (2015) Cytokines play a key role in communication between Mesenchymal stem cells and brain cancer cells. Protein Pept Lett 22:322–331

Article  CAS  PubMed  Google Scholar 

Murillo MM, Del Castillo G, Sánchez A, Fernández M, Fabregat I (2005) Involvement of EGF receptor and c-Src in the survival signals induced by TGF-β1 in hepatocytes. Oncogene 24:4580–4587