The advance of CCN3 in fibrosis

Abd El Kader T, Kubota S, Janune D, Nishida T, Hattori T, Aoyama E, Perbal B, Kuboki T, Takigawa M (2013) Anti-fibrotic effect of CCN3 accompanied by altered gene expression profile of the CCN family. J Cell Commun Signal 7:11–18

Article  PubMed  Google Scholar 

Akashi S, Nishida T, El-Seoudi A, Takigawa M, Iida S, Kubota S (2018) Metabolic regulation of the CCN family genes by glycolysis in chondrocytes. J Cell Commun Signal 12:245–252

Article  PubMed  Google Scholar 

Betageri KR, Link PA, Haak AJ, Ligresti G, Tschumperlin DJ, Caporarello N (2023) The matricellular protein CCN3 supports lung endothelial homeostasis and function. Am J Physiol Lung Cell Mol Physiol 324:L154-l168

Article  CAS  PubMed  Google Scholar 

Bleau AM, Planque N, Lazar N, Zambelli D, Ori A, Quan T, Fisher G, Scotlandi K, Perbal B (2007) Antiproliferative activity of CCN3: involvement of the C-terminal module and post-translational regulation. J Cell Biochem 101:1475–1491

Article  CAS  PubMed  Google Scholar 

Böhlig L, Metzger R, Rother K, Till H, Engeland K (2008) The CCN3 gene coding for an extracellular adhesion-related protein is transcriptionally activated by the p53 tumor suppressor. Cell Cycle 7:1254–1261

Article  PubMed  Google Scholar 

Borkham-Kamphorst E, van Roeyen CR, Van de Leur E, Floege J, Weiskirchen R (2012a) CCN3/NOV small interfering RNA enhances fibrogenic gene expression in primary hepatic stellate cells and cirrhotic fat storing cell line CFSC. J Cell Commun Signal 6:11–25

Article  PubMed  Google Scholar 

Borkham-Kamphorst E, Huss S, Van de Leur E, Haas U, Weiskirchen R (2012b) Adenoviral CCN3/NOV gene transfer fails to mitigate liver fibrosis in an experimental bile duct ligation model because of hepatocyte apoptosis. Liver Int 32:1342–1353

Article  CAS  PubMed  Google Scholar 

Bradham DM, Igarashi A, Potter RL, Grotendorst GR (1991) Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J Cell Biol 114:1285–1294

Article  CAS  PubMed  Google Scholar 

Chen L, Charrier AL, Leask A, French SW, Brigstock DR (2011) Ethanol-stimulated differentiated functions of human or mouse hepatic stellate cells are mediated by connective tissue growth factor. J Hepatol 55:399–406

Article  CAS  PubMed  Google Scholar 

Chen PC, Liu SC, Lin TH, Lin LW, Wu HC, Tai HC, Wang SW, Tang CH (2021) Prostate cancer-secreted CCN3 uses the GSK3β and β-catenin pathways to enhance osteogenic factor levels in osteoblasts. Environ Toxicol 36:425–432

Article  PubMed  Google Scholar 

Colston JT, de la Rosa SD, Koehler M, Gonzales K, Mestril R, Freeman GL, Bailey SR, Chandrasekar B (2007) Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor. Am J Physiol Heart Circ Physiol 293:H1839–H1846

Article  CAS  PubMed  Google Scholar 

Dobson JR, Taipaleenmäki H, Hu YJ, Hong D, van Wijnen AJ, Stein JL, Stein GS, Lian JB, Pratap J (2014) hsa-mir-30c promotes the invasive phenotype of metastatic breast cancer cells by targeting NOV/CCN3. Cancer Cell Int 14:73

Article  PubMed  PubMed Central  Google Scholar 

Fu CT, Bechberger JF, Ozog MA, Perbal B, Naus CC (2004) CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression. J Biol Chem 279:36943–36950

Article  CAS  PubMed  Google Scholar 

Gellhaus A, Dong X, Propson S, Maass K, Klein-Hitpass L, Kibschull M, Traub O, Willecke K, Perbal B, Lye SJ, Winterhager E (2004) Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells. J Biol Chem 279:36931–36942

Article  CAS  PubMed  Google Scholar 

Gellhaus A, Wotzlaw C, Otto T, Fandrey J, Winterhager E (2010) More insights into the CCN3/Connexin43 interaction complex and its role for signaling. J Cell Biochem 110:129–140

CAS  PubMed  Google Scholar 

Henrot P, Moisan F, Laurent P, Manicki P, Kaulanjan-Checkmodine P, Jolivel V, Rezvani HR, Leroy V, Picard F, Boulon C, Schaeverbeke T, Seneschal J, Lazaro E, Taïeb A, Truchetet ME, Cario M (2020) Decreased CCN3 in systemic sclerosis endothelial cells contributes to impaired angiogenesis. J Invest Dermatol 140:1427-1434.e5

Article  CAS  PubMed  Google Scholar 

Hoshijima M, Hattori T, Aoyama E, Nishida T, Yamashiro T, Takigawa M (2012) Roles of heterotypic CCN2/CTGF-CCN3/NOV and homotypic CCN2-CCN2 interactions in expression of the differentiated phenotype of chondrocytes. Febs J 279:3584–3597

Article  CAS  PubMed  Google Scholar 

Huang X, Ni B, Mao Z, Xi Y, Chu X, Zhang R, Ma X, You H (2019) NOV/CCN3 induces cartilage protection by inhibiting PI3K/AKT/mTOR pathway. J Cell Mol Med 23:7525–7534

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jia Q, Xue T, Zhang Q, Cheng W, Zhang C, Ma J, Bu Y, Yu S, Liu Q (2017) CCN3 is a therapeutic target relating enhanced stemness and coagulation in hepatocellular carcinoma. Sci Rep 7:13846

Article  PubMed  PubMed Central  Google Scholar 

Joliot V, Martinerie C, Dambrine G, Plassiart G, Brisac M, Crochet J, Perbal B (1992) Proviral rearrangements and overexpression of a new cellular gene (nov) in myeloblastosis-associated virus type 1-induced nephroblastomas. Mol Cell Biol 12:10–21

CAS  PubMed  PubMed Central  Google Scholar 

Jun JI, Lau LF (2011) Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nat Rev Drug Discov 10:945–963

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kawaki H, Kubota S, Suzuki A, Lazar N, Yamada T, Matsumura T, Ohgawara T, Maeda T, Perbal B, Lyons KM, Takigawa M (2008) Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage. J Bone Miner Res 23:1751–1764

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim H, Son S, Shin I (2018a) Role of the CCN protein family in cancer. BMB Rep 51:486–492

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim Y, Yang H, Min JK, Park YJ, Jeong SH, Jang SW, Shim S (2018b) CCN3 secretion is regulated by palmitoylation via ZDHHC22. Biochem Biophys Res Commun 495:2573–2578

Article  CAS  PubMed  Google Scholar 

Koitabashi N, Arai M, Niwano K, Watanabe A, Endoh M, Suguta M, Yokoyama T, Tada H, Toyama T, Adachi H, Naito S, Oshima S, Nishida T, Kubota S, Takigawa M, Kurabayashi M (2008) Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure. Eur J Heart Fail 10:373–379

Article  CAS  PubMed  Google Scholar 

Kubota S, Kawata K, Hattori T, Nishida T (2022) Molecular and genetic interactions between CCN2 and CCN3 behind their Yin–Yang collaboration. Int J Mol Sci 23(11):5887

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kular L, Pakradouni J, Kitabgi P, Laurent M, Martinerie C (2011) The CCN family: a new class of inflammation modulators? Biochimie 93:377–388

Article  CAS  PubMed  Google Scholar 

Lasky JA, Ortiz LA, Tonthat B, Hoyle GW, Corti M, Athas G, Lungarella G, Brody A, Friedman M (1998) Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis. Am J Physiol 275:L365–L371

CAS  PubMed  Google Scholar 

Leask A (2009) Yin and Yang: CCN3 inhibits the pro-fibrotic effects of CCN2. J Cell Commun Signal 3:161–162

Article  PubMed  PubMed Central  Google Scholar 

Leask A (2015) Yin and Yang revisited: CCN3 as an anti-fibrotic therapeutic? J Cell Commun Signal 9:97–98

Article  PubMed  PubMed Central  Google Scholar 

Leask A (2020) Conjunction junction, what’s the function? CCN proteins as targets in fibrosis and cancers. Am J Physiol Cell Physiol 318:C1046-c1054

Article  CAS  PubMed  Google Scholar 

Leask A, Parapuram SK, Shi-Wen X, Abraham DJ (2009) Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease? J Cell Commun Signal 3:89–94

Article  PubMed  PubMed Central  Google Scholar 

Lemaire R, Farina G, Bayle J, Dimarzio M, Pendergrass SA, Milano A, Perbal B, Whitfield ML, Lafyatis R (2010) Antagonistic effect of the matricellular signaling protein CCN3 on TGF-beta- and Wnt-mediated fibrillinogenesis in systemic sclerosis and Marfan syndrome. J Invest Dermatol 130:1514–1523

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li W, Liao X, Ning P, Cao Y, Zhang M, Bu Y, Lv J, Jia Q (2019) Paracrine effects of CCN3 from non-cancerous hepatic cells increase signaling and progression of hepatocellular carcinoma. BMC Cancer 19:395

Article  PubMed  PubMed Central  Google Scholar 

Lin CG, Leu SJ, Chen N, Tebeau CM, Lin SX, Yeung CY, Lau LF (2003) CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family. J Biol Chem 278:24200–24208

Article  CAS  PubMed 

留言 (0)

沒有登入
gif