Andreotti L, Bussotti A, Cammelli D, Aiello E, Sampognaro S (1983) Connective tissue in aging lung. Gerontology 29:377–387

Article  CAS  PubMed  Google Scholar 

Argyropoulos AJ, Robichaud P, Balimunkwe RM, Fisher GJ, Hammerberg C, Yan Y, Quan T (2016) Alterations of dermal connective tissue collagen in diabetes: molecular basis of aged-appearing skin. PLoS ONE 11:e0153806

Article  PubMed  PubMed Central  Google Scholar 

Ashcroft GS, Horan MA, Ferguson MW (1995) The effects of ageing on cutaneous wound healing in mammals. J Anat 187(Pt 1):1–26

PubMed  PubMed Central  Google Scholar 

Ashcroft GS, Mills SJ, Ashworth JJ (2002) Ageing and wound healing. Biogerontology 3:337–345

Article  CAS  PubMed  Google Scholar 

Bissell MJ, Hines WC (2011) Why don’t we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med 17:320–329

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bissell MJ, Kenny PA, Radisky DC (2005) Microenvironmental regulators of tissue structure and function also regulate tumor induction and progression: the role of extracellular matrix and its degrading enzymes. Cold Spring Harb Symp Quant Biol 70:343–356

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen CC, Lau LF (2009) Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol 41:771–783

Article  CAS  PubMed  Google Scholar 

Chen CC, Chen N, Lau LF (2001) The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts. J Biol Chem 276:10443–10452

Article  CAS  PubMed  Google Scholar 

Dotto GP (2014) Multifocal epithelial tumors and field cancerization: stroma as a primary determinant. J Clin Invest 124:1446–1453

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eaglstein WH (1989) Wound healing and aging. Clin Geriatr Med 5:183–188

Article  CAS  PubMed  Google Scholar 

Fisher GJ, Esmann J, Griffiths CE, Talwar HS, Duell EA, Hammerberg C, Elder JT, Finkel LJ, Karabin GD, Nickoloff BJ et al (1991) Cellular, immunologic and biochemical characterization of topical retinoic acid-treated human skin. J Invest Dermatol 96:699–707

Article  CAS  PubMed  Google Scholar 

Fisher G, Wang Z, Datta S, Varani J, Kang S, Voorhees J (1997) Pathophysiology of premature skin aging induced by ultraviolet light. New Eng J Med 337:1419–1429

Article  CAS  PubMed  Google Scholar 

Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S, Voorhees JJ (2002) Mechanisms of photoaging and chronological skin aging. Arch Dermatol 138:1462–1470

Article  CAS  PubMed  Google Scholar 

Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP (2012) Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell 149:1207–1220

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ingber DE (2008) Can cancer be reversed by engineering the tumor microenvironment? Semin Cancer Biol 18:356–364

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jacob MP (2003) Extracellular matrix remodeling and matrix metalloproteinases in the vascular wall during aging and in pathological conditions. Biomed Pharmacother 57:195–202

Article  CAS  PubMed  Google Scholar 

Jun JI, Lau LF (2010) The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat Cell Biol 12:676–685

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jun JI, Lau LF (2011) Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nat Rev Drug Discov 10:945–963

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kempf T, Zarbock A, Widera C, Butz S, Stadtmann A, Rossaint J, Bolomini-Vittori M, Korf-Klingebiel M, Napp LC, Hansen B et al (2011) GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. Nat Med 17:581–588

Article  CAS  PubMed  Google Scholar 

Lau LF (2011) CCN1/CYR61: the very model of a modern matricellular protein. Cell Mol Life Sci 68:3149–3163

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lau LF (2016) Cell surface receptors for CCN proteins. J Cell Commun Signal 10:121–127

Article  PubMed  PubMed Central  Google Scholar 

Lau L, Lam SC-T (1999a) The CCN family of angiogenic regulators: The integrin connection. Exp Cell Res 248:44–57

Article  CAS  PubMed  Google Scholar 

Lavker RM (1979) Structural alterations in exposed and unexposed aged skin. J Invest Dermatol 73:59–66

Article  CAS  PubMed  Google Scholar 

Perbal B (2004) CCN proteins: multifunctional signalling regulators. Lancet 363:62–64

Article  CAS  PubMed  Google Scholar 

Pickup MW, Mouw JK, Weaver VM (2014) The extracellular matrix modulates the hallmarks of cancer. EMBO Rep 15:1243–1253

Article  CAS  PubMed  PubMed Central  Google Scholar 

Purohit T, Qin Z, Quan C, Lin Z, Quan T (2017) Smad3-dependent CCN2 mediates fibronectin expression in human skin dermal fibroblasts. PLoS ONE 12:e0173191

Article  PubMed  PubMed Central  Google Scholar 

Qin Z, Fisher GJ, Quan T (2013) Cysteine-rich protein 61 (CCN1) domain-specific stimulation of matrix metalloproteinase-1 expression through alphaVbeta3 integrin in human skin fibroblasts. J Biol Chem 288:12386–12394

Article  CAS  PubMed  PubMed Central  Google Scholar 

Quan T, Fisher GJ (2015) Role of age-associated alterations of the dermal extracellular matrix microenvironment in human skin aging: a mini-review. Gerontology 61:427–434

Article  CAS  PubMed  Google Scholar 

Quan T, He T, Kang S, Voorhees JJ, Fisher GJ (2002) Connective tissue growth factor: expression in human skin in vivo and inhibition by ultraviolet irradiation. J Invest Dermatol 118:402–408

Article  CAS  PubMed  Google Scholar 

Quan T, He T, Shao Y, Lin L, Kang S, Voorhees J, Fisher G (2006) Elevated cystein-rich 61 mediates aberrant collagen homeostasis in chronologically aged and photoaged human skin. Amer J Pathol 169:482–490

Article  CAS  Google Scholar 

Quan T, Qin Z, Xu Y, He T, Kang S, Voorhees JJ, Fisher GJ (2010) Ultraviolet irradiation induces CYR61/CCN1, a mediator of collagen homeostasis, through activation of transcription factor AP-1 in human skin fibroblasts. J Invest Dermatol 130:1697–1706

Article  CAS  PubMed  Google Scholar 

Quan T, Xiang Y, Liu Y, Qin Z, Yang Y, Bou-Gharios G, Voorhees JJ, Dlugosz AA, Fisher GJ (2021) Dermal fibroblast CCN1 expression in mice recapitulates human skin dermal aging. J Invest Dermatol 141:1007–1016

Article  CAS  PubMed  Google Scholar 

Thomas DR (2001) Age-related changes in wound healing. Drugs Aging 18:607–620

Article  CAS  PubMed  Google Scholar 

Uitto J, and Bernstein EF (1998) Molecular mechanisms of cutaneous aging: connective tissue alterations in the dermis. In: The journal of investigative dermatology Symposium proceedings/the Society for Investigative Dermatology. Inc [and] European Society for Dermatological Research vol 3, pp 41–44

Vanharanta S, Massague J (2012) Field cancerization: something new under the sun. Cell 149:1179–1181

Article  CAS  PubMed  Google Scholar 

Wlaschek M, Tantcheva-Poor I, Naderi L, Ma W, Schneider LA, Razi-Wolf Z, Schuller J, Scharffetter-Kochanek K (2001) Solar UV irradiation and dermal photoaging. J Photochem Photobiol B 63:41–51

Article  CAS  PubMed  Google Scholar 

Yaar M, Eller MS, Gilchrest BA (2002) Fifty years of skin aging. J Investig Dermatol Symp Proc 7:51–58

Article  PubMed  Google Scholar