Afferni C, Buccione C, Andreone S, Galdiero MR, Varricchi G, Marone G, Mattei F, Schiavoni G (2018) The pleiotropic immunomodulatory functions of IL-33 and its implications in Tumor Immunity. Front Immunol 9:2601

Article  PubMed  PubMed Central  Google Scholar 

Akimoto M, Susa T, Okudaira N, Koshikawa N, Hisaki H, Iizuka M, Okinaga H, Takenaga K, Okazaki T, Tamamori-Adachi M (2023) Hypoxia induces downregulation of the tumor-suppressive sST2 in Colorectal cancer cells via the HIF-nuclear IL-33-GATA3 pathway. Proc Natl Acad Sci U S A 120:e2218033120

Article  CAS  PubMed  Google Scholar 

Alam A, Levanduski E, Denz P, Villavicencio HS, Bhatta M, Alhorebi L, Zhang Y, Gomez EC, Morreale B, Senchanthisai S et al (2022) Fungal mycobiome drives IL-33 secretion and type 2 immunity in Pancreatic cancer. Cancer Cell 40:153–167e111

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ali S, Mohs A, Thomas M, Klare J, Ross R, Schmitz ML, Martin MU (2011) The dual function cytokine IL-33 interacts with the transcription factor NF-kappaB to dampen NF-kappaB-stimulated gene transcription. J Immunol 187:1609–1616

Article  CAS  PubMed  Google Scholar 

Arend WP, Palmer G, Gabay C (2008) IL-1, IL-18, and IL-33 families of cytokines. Immunol Rev 223:20–38

Article  CAS  PubMed  Google Scholar 

Ashton AW, Dhanjal HK, Rossner B, Mahmood H, Patel VI, Nadim M, Lota M, Shahid F, Li Z, Joyce D et al (2022) Acetylation of nuclear receptors in health and Disease: an update. Febs j. https://doi.org/10.1111/febs.16695

Article  PubMed  Google Scholar 

Bessa J, Meyer CA, de Vera Mudry MC, Schlicht S, Smith SH, Iglesias A, Cote-Sierra J (2014) Altered subcellular localization of IL-33 leads to non-resolving lethal inflammation. J Autoimmun 55:33–41

Article  CAS  PubMed  Google Scholar 

Borgia F, Custurone P, Li Pomi F, Vaccaro M, Alessandrello C, Gangemi S (2022) IL-33 and IL-37: a possible Axis in skin and allergic Diseases. Int J Mol Sci 24

Carriere V, Roussel L, Ortega N, Lacorre DA, Americh L, Aguilar L, Bouche G, Girard JP (2007) IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo. Proc Natl Acad Sci U S A 104:282–287

Article  CAS  PubMed  Google Scholar 

Cayrol C, Girard JP (2009) The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. Proc Natl Acad Sci U S A 106:9021–9026

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cayrol C, Girard JP (2018) Interleukin-33 (IL-33): a nuclear cytokine from the IL-1 family. Immunol Rev 281:154–168

Article  CAS  PubMed  Google Scholar 

Cayrol C, Duval A, Schmitt P, Roga S, Camus M, Stella A, Burlet-Schiltz O, Gonzalez-de-Peredo A, Girard JP (2018) Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33. Nat Immunol 19:375–385

Article  CAS  PubMed  Google Scholar 

Chatterjee A, Azevedo-Martins JM, Stachler MD (2023) Interleukin-33 as a potential therapeutic target in gastric Cancer patients: current insights. Onco Targets Ther 16:675–687

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen YL, Gutowska-Owsiak D, Hardman CS, Westmoreland M, MacKenzie T, Cifuentes L, Waithe D, Lloyd-Lavery A, Marquette A, Londei M et al (2019) Proof-of-concept clinical trial of etokimab shows a key role for IL-33 in atopic dermatitis pathogenesis. Sci Transl Med 11

Chinthrajah S, Cao S, Liu C, Lyu SC, Sindher SB, Long A, Sampath V, Petroni D, Londei M, Nadeau KC (2019) Phase 2a randomized, placebo-controlled study of anti-IL-33 in peanut allergy. JCI Insight 4

Choi YS, Park JA, Kim J, Rho SS, Park H, Kim YM, Kwon YG (2012) Nuclear IL-33 is a transcriptional regulator of NF-κB p65 and induces endothelial cell activation. Biochem Biophys Res Commun 421:305–311

Article  CAS  PubMed  Google Scholar 

Chung YH, Qian Q, Huang HY, Chiu WT, Yang CS, Tzeng SF (2021) The Nuclear function of IL-33 in desensitization to DNA damaging Agent and Change of Glioma Nuclear structure. Front Cell Neurosci 15:713336

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clerman A, Noor Z, Fishelevich R, Lockatell V, Hampton BS, Shah NG, Salcedo MV, Todd NW, Atamas SP, Luzina IG (2017) The full-length interleukin-33 (FLIL33)-importin-5 interaction does not regulate nuclear localization of FLIL33 but controls its intracellular degradation. J Biol Chem 292:21653–21661

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dai X, Utsunomiya R, Shiraishi K, Mori H, Muto J, Murakami M, Sayama K (2021) Nuclear IL-33 plays an important role in the suppression of FLG, LOR, Keratin 1, and Keratin 10 by IL-4 and IL-13 in human keratinocytes. J Invest Dermatol 141:2646–2655 e2646

Article  CAS  PubMed  Google Scholar 

Dai X, Muto J, Shiraishi K, Utsunomiya R, Mori H, Murakami M, Sayama K (2022) TSLP Impairs Epidermal Barrier Integrity by stimulating the formation of Nuclear IL-33/Phosphorylated STAT3 complex in human keratinocytes. J Invest Dermatol 142:2100–2108 e2105

Article  CAS  PubMed  Google Scholar 

De Boeck A, Ahn BY, D’Mello C, Lun X, Menon SV, Alshehri MM, Szulzewsky F, Shen Y, Khan L, Dang NH et al (2020) Glioma-derived IL-33 orchestrates an inflammatory Brain Tumor microenvironment that accelerates glioma progression. Nat Commun 11:4997

Article  PubMed  PubMed Central  Google Scholar 

Dominguez D, Ye C, Geng Z, Chen S, Fan J, Qin L, Long A, Wang L, Zhang Z, Zhang Y et al (2017) Exogenous IL-33 restores dendritic cell activation and maturation in established Cancer. J Immunol 198:1365–1375

Article  CAS  PubMed  Google Scholar 

Duan S, Wang J, Lou X, Chen D, Shi P, Jiang H, Wang Z, Li W, Qian F (2023) A novel anti-IL-33 antibody recognizes an epitope FVLHN of IL-33 and has a therapeutic effect on inflammatory Diseases. Int Immunopharmacol 122:110578

Article  CAS  PubMed  Google Scholar 

Dwyer GK, D’Cruz LM, Turnquist HR (2022) Emerging functions of IL-33 in Homeostasis and Immunity. Annu Rev Immunol 40:15–43

Article  PubMed  Google Scholar 

England E, Rees DG, Scott IC, Carmen S, Chan DTY, Chaillan Huntington CE, Houslay KF, Erngren T, Penney M, Majithiya JB et al (2023) Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction. Sci Rep 13:9825

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan M, Yang K, Wang X, Chen L, Gill PS, Ha T, Liu L, Lewis NH, Williams DL, Li C (2023) Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after Myocardial Infarction. Sci Adv 9:eadc9465

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gadina M, Jefferies CA (2007) IL-33: a sheep in wolf’s clothing? Sci STKE 2007: pe31

Garbern JC, Williams J, Kristl AC, Malick A, Rachmin I, Gaeta B, Ahmed N, Vujic A, Libby P, Lee RT (2019) Dysregulation of IL-33/ST2 signaling and myocardial periarteriolar fibrosis. J Mol Cell Cardiol 128:179–186

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gatti F, Mia S, Hammarström C, Frerker N, Fosby B, Wang J, Pietka W, Sundnes O, Hol J, Kasprzycka M et al (2021) Nuclear IL-33 restrains the early conversion of fibroblasts to an extracellular matrix-secreting phenotype. Sci Rep 11:108

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gordon ED, Simpson LJ, Rios CL, Ringel L, Lachowicz-Scroggins ME, Peters MC, Wesolowska-Andersen A, Gonzalez JR, MacLeod HJ, Christian LS et al (2016) Alternative splicing of interleukin-33 and type 2 inflammation in Asthma. Proc Natl Acad Sci U S A 113: 8765–8770

Guertin DA, Wellen KE (2023) Acetyl-CoA metabolism in cancer. Nat Rev Cancer 23:156–172

Article  CAS  PubMed  Google Scholar 

Hagihara H, Shoji H, Otabi H, Toyoda A, Katoh K, Namihira M, Miyakawa T (2021) Protein lactylation induced by neural excitation. Cell Rep 37:109820

Article  CAS  PubMed  Google Scholar 

Haraldsen G, Balogh J, Pollheimer J, Sponheim J, Kuchler AM (2009) Interleukin-33 - cytokine of dual function or novel alarmin? Trends Immunol 30:227–233

Article  CAS  PubMed  Google Scholar 

Hatzioannou A, Banos A, Sakelaropoulos T, Fedonidis C, Vidali MS, Kohne M, Handler K, Boon L, Henriques A, Koliaraki V et al (2020) An intrinsic role of IL-33 in T(reg) cell-mediated Tumor immunoevasion. Nat Immunol 21:75–85

Article  CAS  PubMed  Google Scholar 

Heinrich B, Gertz EM, Schäffer AA, Craig A, Ruf B, Subramanyam V, McVey JC, Diggs LP, Heinrich S, Rosato U et al (2022) The tumour microenvironment shapes innate lymphoid cells in patients with hepatocellular carcinoma. Gut 71:1161–1175

Article  CAS  PubMed  Google Scholar 

Henning NJ, Boike L, Spradlin JN, Ward CC, Liu G, Zhang E, Belcher BP, Brittain SM, Hesse MJ, Dovala D et al (2022) Deubiquitinase-targeting chimeras for targeted protein stabilization. Nat Chem Biol 18:412–421

Article  CAS  PubMed  PubMed Central  Google Scholar 

Holgado A, Liu Z, Aidarova A, Mueller C, Haegman M, Driege Y, Kreike M, Scott CL, Afonina IS, Beyaert R (2023) A20 is a master switch of IL-33 signaling in macrophages and determines IL-33-induced lung immunity. J Allergy Clin Immunol 152:244–256e244

Article  CAS  PubMed  Google Scholar 

Iijima K, Kobayashi T, Matsumoto K, Ohara K, Kita H, Drake LY (2021) Transient IL-33 upregulation in neonatal mouse lung promotes acute but not chronic type 2 immune responses induced by allergen later in life. PLoS ONE 16:e0252199

Article  CAS