Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I et al (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74(3):229–263

Article  PubMed  Google Scholar 

Siegel RL, Giaquinto AN, Jemal A (2024) Cancer statistics, 2024. CA Cancer J Clin 74(1):12–49

Article  PubMed  Google Scholar 

Burz C, Pop V, Silaghi C, Lupan I, Samasca G (2024) Prognosis and treatment of gastric cancer: a 2024 update. Cancers (Basel) 16(9):1708

Article  CAS  PubMed  Google Scholar 

Rizzo A, Mollica V, Ricci AD, Maggio I, Massucci M, Rojas Limpe FL et al (2020) Third- and later-line treatment in advanced or metastatic gastric cancer: a systematic review and meta-analysis. Future Oncol 16(2):4409–4418

Article  CAS  PubMed  Google Scholar 

Guan WL, He Y, Xu RH (2023) Gastric cancer treatment: recent progress and future perspectives. J Hematol Oncol 16(1):57

Article  CAS  PubMed  PubMed Central  Google Scholar 

Seeneevassen L, Zaafour A, Sifre E, Genevois C, Nguyen TL, Pobiedonoscew Y et al (2024) Targeting metastasis-initiating cancer stem cells in gastric cancer with leukaemia inhibitory factor. Cell Death Discov 10(1):120

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brandl A, van Sandick JW (2024) Treatment of gastric cancer peritoneal metastases: role of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. British J Surg. https://doi.org/10.1093/bjs/znae149

Article  Google Scholar 

Liongue C, Sobah ML, Ward AC (2023) Signal transducer and activator of transcription proteins at the nexus of immunodeficiency, autoimmunity and cancer. Biomedicines 12(1):45. https://doi.org/10.3390/biomedicines12010045

Article  CAS  PubMed  PubMed Central  Google Scholar 

Loh CY, Arya A, Naema AF, Wong WF, Sethi G, Looi CY (2019) Signal transducer and activator of transcription (STATs) proteins in cancer and inflammation: functions and therapeutic implication. Front Oncol 9:48

Article  PubMed  PubMed Central  Google Scholar 

Bromberg J, Darnell JE Jr (2000) The role of STATs in transcriptional control and their impact on cellular function. Oncogene 19(21):2468–2473

Article  CAS  PubMed  Google Scholar 

Xue C, Yao Q, Gu X, Shi Q, Yuan X, Chu Q et al (2023) Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer. Signal Transduct Target Ther 8(1):204

Article  PubMed  PubMed Central  Google Scholar 

Hu X, Li J, Fu M, Zhao X, Wang W (2021) The JAK/STAT signaling pathway: from bench to clinic. Signal Transduct Target Ther 6(1):402

Article  PubMed  PubMed Central  Google Scholar 

Verhoeven Y, Tilborghs S, Jacobs J, De Waele J, Quatannens D, Deben C et al (2020) The potential and controversy of targeting STAT family members in cancer. Semin Cancer Biol 60:41–56

Article  CAS  PubMed  Google Scholar 

He Z, Zhang X, Wang S, Dai X, Wang Q, Lu Q et al (2023) The predictive value of prognosis and therapeutic response for STAT family in pancreatic cancer. Heliyon 9(5):e16150

Article  CAS  PubMed  PubMed Central  Google Scholar 

Standing D, Feess E, Kodiyalam S, Kuehn M, Hamel Z, Johnson J, Thomas SM, Anant S (2023) The role of STATs in ovarian cancer: exploring their potential for therapy. Cancers 15(9):2485. https://doi.org/10.3390/cancers15092485

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim DY, Cha ST, Ahn DH, Kang HY, Kwon CI, Ko KH et al (2009) STAT3 expression in gastric cancer indicates a poor prognosis. J Gastroenterol Hepatol 24(4):646–651

Article  CAS  PubMed  Google Scholar 

Li X, Pan K, Vieth M, Gerhard M, Li W, Mejías-Luque R (2022) JAK-STAT1 signaling pathway is an early response to helicobacter pylori infection and contributes to immune escape and gastric carcinogenesis. Int J Mol Sci 23(8):4147. https://doi.org/10.3390/ijms23084147

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nishi M, Batsaikhan BE, Yoshikawa K, Higashijima J, Tokunaga T, Takasu C et al (2017) High STAT4 expression indicates better disease-free survival in patients with gastric cancer. Anticancer Res 37(12):6723–6729

CAS  PubMed  Google Scholar 

Oh SC, Sohn BH, Cheong JH, Kim SB, Lee JE, Park KC et al (2018) Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype. Nat Commun 9(1):1777

Article  PubMed  PubMed Central  Google Scholar 

Brasacchio D, Busuttil RA, Noori T, Johnstone RW, Boussioutas A, Trapani JA (2018) Down-regulation of a pro-apoptotic pathway regulated by PCAF/ADA3 in early stage gastric cancer. Cell Death Dis 9(5):442

Article  PubMed  PubMed Central  Google Scholar 

Subhash VV, Yeo MS, Wang L, Tan SH, Wong FY, Thuya WL et al (2018) Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor. Sci Rep 8(1):12248

Article  PubMed  PubMed Central  Google Scholar 

Kim HK, Choi IJ, Kim CG, Kim HS, Oshima A, Yamada Y et al (2012) Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy. Pharmacogen J 12(2):119–127

Article  CAS  Google Scholar 

Forster S, Gretschel S, Jons T, Yashiro M, Kemmner W (2011) THBS4, a novel stromal molecule of diffuse-type gastric adenocarcinomas, identified by transcriptome-wide expression profiling. Mod Pathol 24(10):1390–1403

Article  PubMed  Google Scholar 

Wang G, Hu N, Yang HH, Wang L, Su H, Wang C et al (2013) Comparison of global gene expression of gastric cardia and noncardia cancers from a high-risk population in china. PLoS ONE 8(5):e63826

Article  PubMed  PubMed Central  Google Scholar 

Davis S, Meltzer PS (2007) GEOquery: a bridge between the gene expression omnibus (GEO) and bio conductor. Bioinformatics 23(14):1846–1847

Article  PubMed  Google Scholar 

Leek JT, Johnson WE, Parker HS, Jaffe AE, Storey JD (2012) The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics 28(6):882–883

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giraud AS, Menheniott TR, Judd LM (2012) Targeting STAT3 in gastric cancer. Expert Opin Ther Targets 16(9):889–901

Article  CAS  PubMed  Google Scholar 

Gao S, Chen M, Wei W, Zhang X, Zhang M, Yao Y et al (2019) Crosstalk of mTOR/PKM2 and STAT3/c-Myc signaling pathways regulate the energy metabolism and acidic microenvironment of gastric cancer. J Cell Biochem 120(2):1193–1202

Article  CAS  PubMed  Google Scholar 

Goyal H, Chachoua I, Pecquet C, Vainchenker W, Constantinescu SN (2020) A p53-JAK-STAT connection involved in myeloproliferative neoplasm pathogenesis and progression to secondary acute myeloid leukemia. Blood Rev 42:100712

Article  CAS  PubMed  Google Scholar 

Pencik J, Schlederer M, Gruber W, Unger C, Walker SM, Chalaris A et al (2015) STAT3 regulated ARF expression suppresses prostate cancer metastasis. Nat Commun 6:7736

Article  CAS  PubMed  Google Scholar 

Yin YT, Shi L, Wu C, Zhang MY, Li JX, Zhou YF et al (2024) TRIM29 modulates proteins involved in PTEN/AKT/mTOR and JAK2/STAT3 signaling pathway and suppresses the progression of hepatocellular carcinoma. Med Onc