Adzhubei, I., Jordan, D. M., & Sunyaev, S. R. (2013). Predicting functional effect of human missense mutations using PolyPhen‐2. Current protocols in human genetics, 76(1), 7.20. 21–27.20. 41.

Aimo, A., Botto, N., Vittorini, S., & Emdin, M. (2019). Polymorphisms in the eNOS gene and the risk of coronary artery disease: Making the case for genome-wide association studies. In: SAGE Publications Sage UK: London, England.

Bae, S.-C., & Lee, Y. H. (2019). Associations between paraoxonase 1 (PON1) polymorphisms and susceptibility and PON1 activity in rheumatoid arthritis patients, and comparison of PON1 activity in patients and controls: a meta-analysis. Clinical rheumatology, 1–9.

Boronat M, Tugores A, Saavedra P, Garay P, Bosch E, Lorenzo D, García-Cantón C (2021) NOS3 rs1799983 and rs2070744 polymorphisms and their association with advanced chronic kidney disease and coronary heart disease in Canarian population with type 2 diabetes. Acta Endocrinol (Bucharest) 17(4):440

Article  CAS  Google Scholar 

Bowden J, Tierney JF, Copas AJ, Burdett S (2011) Quantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised qstatistics. BMC Med Res Methodol 11(1):1–12

Article  Google Scholar 

Carter HE, Schofield D, Shrestha R (2019) Productivity costs of cardiovascular disease mortality across disease types and socioeconomic groups. Open heart 6(1):e000939

Article  PubMed  PubMed Central  Google Scholar 

Collins A, Ke X (2012) Primer1: primer design web service for tetra-primer ARMS-PCR. Open Bioinf J 6:55–58

Article  Google Scholar 

Callo Quinte G, Barros F, Gigante DP, de Oliveira IO, dos Santos Motta JV, Horta BL (2019) Overweight trajectory and cardio metabolic risk factors in young adults. BMC Pediatr 19:1–8

Article  Google Scholar 

Dasseux, J.-L., & Barbaras, R. (2018). Hdl therapy markers. In: Google Patents.

Della-Morte D, Guadagni F, Palmirotta R, Testa G, Caso V, Paciaroni M, Sacco RL (2012) Genetics of ischemic stroke, stroke-related risk factors, stroke precursors and treatments. Pharmacogenomics 13(5):595–613

Article  PubMed  CAS  Google Scholar 

El-Lebedy D (2018) Interaction between endothelial nitric oxide synthase rs1799983, cholesteryl ester-transfer protein rs708272 and angiopoietin-like protein 8 rs2278426 gene variants highly elevates the risk of type 2 diabetes mellitus and cardiovascular disease. Cardiovasc Diabetol 17(1):1–10

Article  Google Scholar 

Fang C, Ren X, Zhou H, Gong ZC, Shen L, Bai J, Zhou HH (2014) Effects of eNOS rs1799983 and ACE rs4646994 polymorphisms on the therapeutic efficacy of salvianolate injection in Chinese patients with coronary heart disease. Clin Exp Pharmacol Physiology 41(8):558–564

Article  CAS  Google Scholar 

Fernández, X. M., & Birney, E. (2010). Ensembl genome browser. Vogel and Motulsky's Human Genetics, 923–939.

Fouda EAAM, Badr EA, Gawesh D, Mahmoud MA (2024) The role of NOS3-rs1799983 and NOS3-rs2070744 SNP in occurrence of avascular necrosis as a post COVID-19 complication. BMC Med Genomics 17(1):217

Article  PubMed  PubMed Central  CAS  Google Scholar 

Han Y, Dorajoo R, Ke T, Ayala B, Chang X, Khor C-C, Liu J (2015) Interaction effects between Paraoxonase 1 variants and cigarette smoking on risk of coronary heart disease in a Singaporean Chinese population. Atherosclerosis 240(1):40–45

Article  PubMed  PubMed Central  CAS  Google Scholar 

Huang, X., Lin, J., & Demner-Fushman, D. (2006). Evaluation of PICO as a knowledge representation for clinical questions. Paper presented at the AMIA annual symposium proceedings.

Humbert R, Adler DA, Disteche CM, Hassett C, Omiecinski CJ, Furlong CE (1993) The molecular basis of the human serum paraoxonase activity polymorphism. Nat Genet 3(1):73–76

Article  PubMed  CAS  Google Scholar 

Jeelani H, Ganie MA, Amin S, Fatima Q, Kawa IA, Manzoor S, Rashid F (2019) Effect of Paraoxonase1 (PON1) gene polymorphisms on PON1 activity, HDL, LDL and MDA levels in women with polycystic ovary syndrome (PCOS): a case-control study. Meta Gene 20:100552

Article  Google Scholar 

Kanai M, Akiyama M, Takahashi A, Matoba N, Momozawa Y, Ikeda M, Matsuda K (2018) Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. Nature genetics 50(3):390

Article  PubMed  CAS  Google Scholar 

Kazmi T, Nagi M, Razzaq S, Hussnain S, Shahid N, Athar U (2022) Burden of noncommunicable diseases in Pakistan. East Mediterr Health J 28(11):798–804

Article  PubMed  Google Scholar 

Kelley LA, Mezulis S, Yates CM, Wass MN, Sternberg MJ (2015) The Phyre2 web portal for protein modeling, prediction and analysis. Nat Protoc 10(6):845–858

Article  PubMed  PubMed Central  CAS  Google Scholar 

Khatami M, Ratki FM, Tajfar S, Akrami F (2017) Relationship of the MTHFD1 (rs2236225), eNOS (rs1799983), CBS (rs2850144) and ACE (rs4343) gene polymorphisms in a population of Iranian pediatric patients with congenital heart defects. Kaohsiung J Med Sci 33(9):442–448

Article  PubMed  Google Scholar 

Kokubo Y, Padmanabhan S, Iwashima Y, Yamagishi K, Goto A (2019) Gene and environmental interactions according to the components of lifestyle modifications in hypertension guidelines. Environ Health Prev Med 24(1):19

Article  PubMed  PubMed Central  Google Scholar 

Li X, Lin Y, Zhang R (2019) Associations between endothelial nitric oxide synthase gene polymorphisms and the risk of coronary artery disease: A systematic review and meta-analysis of 132 case-control studies. Eur J Prev Cardiol 26(2):160–170

Article  PubMed  Google Scholar 

Liu T, Zhang X, Zhang J, Liang Z, Cai W, Huang M, Han Y (2014) Association between PON1 rs662 polymorphism and coronary artery disease. Eur J clin nutr 68(9):1029–1035

Article  PubMed  CAS  Google Scholar 

Lo CK-L, Mertz D, Loeb M (2014) Newcastle-Ottawa Scale: comparing reviewers’ to authors’ assessments. BMC Med Res Methodol 14:1–5

Article  Google Scholar 

Luo Z, Jia A, Lu Z, Muhammad I, Adenrele A, Song Y (2019) Associations of the NOS3 rs1799983 polymorphism with circulating nitric oxide and lipid levels: a systematic review and meta-analysis. Postgrad Med J 95(1125):361–371

Article  PubMed  CAS  Google Scholar 

Mackness B, Mackness MI, Arrol S, Turkie W, Durrington PN (1997) Effect of the molecular polymorphisms of human paraoxonase (PON1) on the rate of hydrolysis of paraoxon. Br J Pharmacol 122(2):265

Article  PubMed  PubMed Central  CAS  Google Scholar 

Maculewicz E, Pabin A, Kowalczuk K, Dziuda Ł, Białek A (2022) Endogenous risk factors of cardiovascular diseases (CVDs) in military professionals with a special emphasis on military pilots. J Clin Med 11(15):4314

Article  PubMed  PubMed Central  Google Scholar 

Menezes PMN, Brito MC, de Paiva GO, dos Santos CO, de Oliveira LM, de Araújo Ribeiro LA, Silva FS (2018) Relaxant effect of Lippia origanoides essential oil in guinea-pig trachea smooth muscle involves potassium channels and soluble guanylyl cyclase. J ethnopharmacol 220:16–25

Article  PubMed  CAS  Google Scholar 

Munshi R, Panchal F, Chaurasia A, Rajadhyaksha G (2018) Association between Paraoxonase 1 (PON1) gene polymorphisms and PON1 enzyme activity in indian patients with coronary artery disease (CAD). Current Pharmacogenomics Personal Med (Formerly Current Pharmacogenomics) 16(3):219–229

Article  CAS  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Brennan SE (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Int J surg 88:105906

Article  PubMed  Google Scholar 

Pawlik A, Błaszczyk H, Rać M, Maciejewska-Skrendo A, Safranow K, Dziedziejko V (2020) NOS3 gene rs1799983 and rs2070744 polymorphisms in patients with unstable angina. J Vasc Res 57(3):136–142

Article  PubMed  CAS  Google Scholar 

Rasheed K, Hussain S, Alam M (2019) Awareness of coronary artery disease risk factors among patients at a tertiary care hospital in Rawalpindi Pakistan. Pak J Public Health 9(1):12–14

Article  Google Scholar 

Raza ST, Singh SP, Rizvi S, Zaidi A, Srivastava S, Hussain A, Mahdi F (2021) Association of eNOS (G894T, rs1799983) and KCNJ11 (E23K, rs5219) gene polymorphism with coronary artery disease in North Indian population. Afr Health Sci 21(3):1163–1171

Article  PubMed  PubMed Central  Google Scholar 

Severino P, D’Amato A, Prosperi S, Magnocavallo M, Mariani MV, Netti L, Maestrini V (2021) Potential role of eNOS genetic variants in ischemic heart disease susceptibility and clinical presentation. J Cardiovasc Dev Dis 8(9):116

PubMed  PubMed Central  CAS  Google Scholar 

Shyu H-Y, Chen M-H, Hsieh Y-H, Shieh J-C, Yen L-R, Wang H-W, Cheng C-W (2017) Association of eNOS and Cav-1 gene polymorphisms with susceptibility risk of large artery atherosclerotic stroke. PLoS ONE 12(3):e0174110

Article  PubMed  PubMed Central