Genetic links between atopy, allergy, and alopecia areata: insights from a Mendelian randomization study

Zhou C, Li X, Wang C, Zhang J. Alopecia areata: an update on etiopathogenesis, diagnosis, and management. Clin Rev Allergy Immunol. 2021;61:403–23.

Article  PubMed  Google Scholar 

Sy N, Mastacouris N, Strunk A, Garg A. Overall and racial and ethnic subgroup prevalences of alopecia areata, alopecia totalis, and alopecia universalis. JAMA Dermatol. 2023;159:419–23.

Article  PubMed  PubMed Central  Google Scholar 

Lee S, Lee H, Lee CH, Lee W-S. Comorbidities in alopecia areata: a systematic review and meta-analysis. J Am Acad Dermatol. 2019;80:466-477.e16.

Article  PubMed  Google Scholar 

Okhovat J-P, Marks DH, Manatis-Lornell A, Hagigeorges D, Locascio JJ, Senna MM. Association between alopecia areata, anxiety, and depression: a systematic review and meta-analysis. J Am Acad Dermatol. 2023;88:1040–50.

Article  CAS  PubMed  Google Scholar 

Suárez-Fariñas M, Ungar B, Noda S, Shroff A, Mansouri Y, Fuentes-Duculan J, et al. Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing. J Allergy Clin Immunol. 2015;136:1277–87.

Article  PubMed  Google Scholar 

Conic RZ, Miller R, Piliang M, Bergfeld W, Atanaskova MN. Comorbidities in patients with alopecia areata. J Am Acad Dermatol. 2017;76:755–7.

Article  PubMed  Google Scholar 

Barahmani N, Schabath MB, Duvic M, National Alopecia Areata Registry. History of atopy or autoimmunity increases risk of alopecia areata. J Am Acad Dermatol. 2009;61:581–91.

Article  PubMed  Google Scholar 

Zhang X, McElwee KJ. Allergy promotes alopecia areata in a subset of patients. Exp Dermatol. 2020;29:239–42.

Article  PubMed  Google Scholar 

Hernán MA. Methods of public health research—strengthening causal inference from observational data. N Engl J Med. 2021;385:1345–8.

Article  PubMed  Google Scholar 

Skrivankova VW, Richmond RC, Woolf BAR, Davies NM, Swanson SA, VanderWeele TJ, et al. Strengthening the reporting of observational studies in epidemiology using Mendelian randomisation (STROBE-MR): explanation and elaboration. BMJ. 2021;375: n2233.

Article  PubMed  PubMed Central  Google Scholar 

Hu X, Zhao J, Lin Z, Wang Y, Peng H, Zhao H, et al. Mendelian randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics. Proc Natl Acad Sci USA. 2022;119: e2106858119.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sanjuan MA, Sagar D, Kolbeck R. Role of IgE in autoimmunity. J Allergy Clin Immunol. 2016;137:1651–61.

Article  CAS  PubMed  Google Scholar 

Burgess S, O’Donnell CJ, Gill D. Expressing results from a Mendelian randomization analysis: separating results from inferences. JAMA Cardiol. 2021;6:7–8.

PubMed  PubMed Central  Google Scholar 

Davies NM, Holmes MV, Davey SG. Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ. 2018;362: k601.

Article  PubMed  PubMed Central  Google Scholar 

Becker J, Burik CAP, Goldman G, Wang N, Jayashankar H, Bennett M, et al. Resource profile and user guide of the polygenic index repository. Nat Hum Behav. 2021;5:1744–58.

Article  PubMed  PubMed Central  Google Scholar 

Foley CN, Staley JR, Breen PG, Sun BB, Kirk PDW, Burgess S, et al. A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits. Nat Commun. 2021;12:764.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kurki MI, Karjalainen J, Palta P, Sipilä TP, Kristiansson K, Donner KM, et al. FinnGen provides genetic insights from a well-phenotyped isolated population. Nature. 2023;613:508–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sadik A, Dardani C, Pagoni P, Havdahl A, Stergiakouli E, iPSYCH Autism Spectrum Disorder Working Group, et al. Parental inflammatory bowel disease and autism in children. Nat Med. 2022;28:1406–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo S, Au Yeung SL, Zhao JV, Burgess S, Schooling CM. Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction: Mendelian randomisation study in UK Biobank. BMJ. 2019;364: l476.

Article  PubMed  PubMed Central  Google Scholar 

Li P, Wang H, Guo L, Gou X, Chen G, Lin D, et al. Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study. BMC Med. 2022;20:443.

Article  PubMed  PubMed Central  Google Scholar 

Chen X, Hong X, Gao W, Luo S, Cai J, Liu G, et al. Causal relationship between physical activity, leisure sedentary behaviors and COVID-19 risk: a Mendelian randomization study. J Transl Med. 2022;20:216.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kawai VK, Shi M, Feng Q, Chung CP, Liu G, Cox NJ, et al. Pleiotropy in the genetic predisposition to rheumatoid arthritis: a phenome-wide association study and inverse variance-weighted meta-analysis. Arthritis Rheumatol. 2020;72:1483–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Disney-Hogg L, Cornish AJ, Sud A, Law PJ, Kinnersley B, Jacobs DI, et al. Impact of atopy on risk of glioma: a Mendelian randomisation study. BMC Med. 2018;16:42.

Article  PubMed  PubMed Central  Google Scholar 

Verbanck M, Chen C-Y, Neale B, Do R. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet. 2018;50:693–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Long Y, Tang L, Zhou Y, Zhao S, Zhu H. Causal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study. BMC Med. 2023;21:66.

Article  PubMed  PubMed Central  Google Scholar 

Xie B, Sun J, Song X. Hair follicle melanocytes initiate autoimmunity in alopecia areata: a trigger point. Clin Rev Allergy Immunol. 2022;63:417–30.

Article  CAS  PubMed  Google Scholar 

Guttman-Yassky E, Renert-Yuval Y, Bares J, Chima M, Hawkes JE, Gilleaudeau P, et al. Phase 2a randomized clinical trial of dupilumab (anti-IL-4Rα) for alopecia areata patients. Allergy. 2022;77:897–906.

Article  CAS  PubMed  Google Scholar 

Marks DH, Mesinkovska N, Senna MM. Cause or cure? Review of dupilumab and alopecia areata. J Am Acad Dermatol. 2023;88:651–3.

Article  PubMed  Google Scholar 

留言 (0)

沒有登入
gif