Clarke AE, Elliott SJ, St Pierre Y, Soller L, La Vieille S, Ben-Shoshan M. Temporal trends in prevalence of food allergy in Canada. J Allergy Clin Immunol Pract. 2020;8(4):1428–30. e5.

Article  PubMed  Google Scholar 

Gupta RS, Warren CM, Smith BM, Jiang J, Blumenstock JA, Davis MM, et al. Prevalence and severity of Food allergies among US adults. JAMA Netw Open. 2019;2(1):e185630.

Article  PubMed  PubMed Central  Google Scholar 

Peters RL, Krawiec M, Koplin JJ, Santos AF. Update on food allergy. Pediatr Allergy Immunol. 2021;32(4):647–57.

Article  PubMed  PubMed Central  Google Scholar 

Gupta RS, Warren CM, Smith BM, Blumenstock JA, Jiang J, Davis MM et al. The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States. Pediatrics. 2018;142(6).

Lieberman JA, Gupta RS, Knibb RC, Haselkorn T, Tilles S, Mack DP, et al. The global burden of illness of peanut allergy: a comprehensive literature review. Allergy. 2021;76(5):1367–84.

Article  PubMed  Google Scholar 

Ferro MA, Van Lieshout RJ, Ohayon J, Scott JG. Emotional and behavioral problems in adolescents and young adults with food allergy. Allergy. 2016;71(4):532–40.

Article  CAS  PubMed  Google Scholar 

Springston EE, Smith B, Shulruff J, Pongracic J, Holl J, Gupta RS. Variations in quality of life among caregivers of food allergic children. Ann Allergy Asthma Immunol. 2010;105(4):287–94.

Article  PubMed  Google Scholar 

Begin P, Chan ES, Kim H, Wagner M, Cellier MS, Favron-Godbout C, et al. CSACI guidelines for the ethical, evidence-based and patient-oriented clinical practice of oral immunotherapy in IgE-mediated food allergy. Allergy Asthma Clin Immunol. 2020;16:20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pajno GB, Fernandez-Rivas M, Arasi S, Roberts G, Akdis CA, Alvaro-Lozano M, et al. EAACI guidelines on allergen immunotherapy: IgE-mediated food allergy. Allergy. 2018;73(4):799–815.

Article  CAS  PubMed  Google Scholar 

Nurmatov U, Dhami S, Arasi S, Pajno GB, Fernandez-Rivas M, Muraro A, et al. Allergen Immunotherapy for IgE-mediated food allergy: a systematic review and meta-analysis. Allergy. 2017;72(8):1133–47.

Article  CAS  PubMed  Google Scholar 

Burks AW, Jones SM, Wood RA, Fleischer DM, Sicherer SH, Lindblad RW, et al. Oral immunotherapy for treatment of egg allergy in children. N Engl J Med. 2012;367(3):233–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jones SM, Burks AW, Keet C, Vickery BP, Scurlock AM, Wood RA, et al. Long-term treatment with egg oral immunotherapy enhances sustained unresponsiveness that persists after cessation of therapy. J Allergy Clin Immunol. 2016;137(4):1117–e2710.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mack DP, Dribin TE, Turner PJ, Wasserman RL, Hanna MA, Shaker M et al. Preparing patients for oral immunotherapy (PPOINT): International Delphi consensus for procedural preparation and consent. J Allergy Clin Immunol. 2024;153(6):1621–1633

Johansson E, Mersha TB. Genetics of Food Allergy. Immunol Allergy Clin North Am. 2021;41(2):301–19.

Article  PubMed  PubMed Central  Google Scholar 

Nuyttens L, De Vlieger L, Diels M, Schrijvers R, Bullens DMA. The clinical and immunological basis of early food introduction in food allergy prevention. Front Allergy. 2023;4:1111687.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kanchan K, Clay S, Irizar H, Bunyavanich S, Mathias RA. Current insights into the genetics of food allergy. J Allergy Clin Immunol. 2021;147(1):15–28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang C, Wu H, Lu Q. The epigenetics of Food Allergy. Adv Exp Med Biol. 2020;1253:141–52.

Article  CAS  PubMed  Google Scholar 

Syed A, Garcia MA, Lyu SC, Bucayu R, Kohli A, Ishida S, et al. Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3). J Allergy Clin Immunol. 2014;133(2):500–10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mondoulet L, Dioszeghy V, Busato F, Plaquet C, Dhelft V, Bethune K, et al. Gata3 hypermethylation and Foxp3 hypomethylation are associated with sustained protection and bystander effect following epicutaneous immunotherapy in peanut-sensitized mice. Allergy. 2019;74(1):152–64.

Article  CAS  PubMed  Google Scholar 

He Z, Vadali VG, Szabady RL, Zhang W, Norman JM, Roberts B, et al. Increased diversity of gut microbiota during active oral immunotherapy in peanut-allergic adults. Allergy. 2021;76(3):927–30.

Article  PubMed  Google Scholar 

Shibata R, Itoh N, Nakanishi Y, Kato T, Suda W, Nagao M, et al. Gut microbiota and fecal metabolites in sustained unresponsiveness by oral immunotherapy in school-age children with cow’s milk allergy. Allergol Int. 2024;73(1):126–36.

Article  CAS  PubMed  Google Scholar 

Kanchan K, Shankar G, Huffaker MF, Bahnson HT, Chinthrajah RS, Sanda S, et al. HLA-associated outcomes in peanut oral immunotherapy trials identify mechanistic and clinical determinants of therapeutic success. Front Immunol. 2022;13:941839.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Virkud YV, Styles JN, Kelly RS, Patil SU, Ruiter B, Smith NP et al. Metabolomics of IgE-Mediated Food Allergy and Oral Immunotherapy Outcomes based on Metabolomic Profiling. medRxiv. 2024.

Heinzerling L, Mari A, Bergmann KC, Bresciani M, Burbach G, Darsow U, et al. The skin prick test - European standards. Clin Transl Allergy. 2013;3(1):3.

Article  PubMed  PubMed Central  Google Scholar 

Standards for the diagnosis. And care of patients with chronic obstructive pulmonary disease (COPD) and asthma. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, November 1986. Am Rev Respir Dis. 1987;136(1):225–44.

Google Scholar 

Burris AD, Lomas JM, Jarvinen KM. Is it time to offer peanut oral immunotherapy to toddlers? J Allergy Clin Immunol Pract. 2021;9(3):1357–8.

Article  CAS  PubMed  Google Scholar 

Team RC. R: a language and environment for statistical computing. Austria: R Foundation for Statistical Computing. Vienna; 2013.

Google Scholar 

Warren CM, Jiang J, Gupta RS. Epidemiology and Burden of Food Allergy. Curr Allergy Asthma Rep. 2020;20(2):6.

Article  PubMed  PubMed Central  Google Scholar 

Singer AG, Kosowan L, Soller L, Chan ES, Nankissoor NN, Phung RR, et al. Prevalence of physician-reported Food Allergy in Canadian Children. J Allergy Clin Immunol Pract. 2021;9(1):193–9.

Article  PubMed  Google Scholar 

Sicherer SH, Sampson HA. Food allergy: a review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J Allergy Clin Immunol. 2018;141(1):41–58.

Article  CAS  PubMed  Google Scholar 

Fleischer DM, Chan ES, Venter C, Spergel JM, Abrams EM, Stukus D, et al. A Consensus Approach to the Primary Prevention of Food Allergy through Nutrition: Guidance from the American Academy of Allergy, Asthma, and Immunology; American College of Allergy, Asthma, and Immunology; and the Canadian Society for Allergy and Clinical Immunology. J Allergy Clin Immunol Pract. 2021;9(1):22–43. e4.

Article  CAS  PubMed  Google Scholar 

Brough HA, Nadeau KC, Sindher SB, Alkotob SS, Chan S, Bahnson HT, et al. Epicutaneous sensitization in the development of food allergy: what is the evidence and how can this be prevented? Allergy. 2020;75(9):2185–205.

Article  PubMed  Google Scholar 

Spergel JM. From atopic dermatitis to asthma: the atopic march. Ann Allergy Asthma Immunol. 2010;105(2):99–106. quiz 7–9, 17.

Article  CAS  PubMed  Google Scholar 

Cafarotti A, Giovannini M, Begin P, Brough HA, Arasi S. Management of IgE-mediated food allergy in the 21st century. Clin Experimental Allergy: J Br Soc Allergy Clin Immunol. 2023;53(1):25–38.

Article  CAS