Shafiani S, Tucker-Heard G, Kariyone A, Takatsu K, Urdahl KB. Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis. J Exp Med. 2010;207:1409–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Urdahl KB. Understanding and overcoming the barriers to T-cell-mediated immunity against tuberculosis. Semin Immunol. 2014;26:578–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bell LCK, Noursadeghi M. Pathogenesis of HIV-1 and Mycobacterium tuberculosis coinfection. Nat Rev Microbiol. 2018;16:80–90.

Article  CAS  PubMed  Google Scholar 

Winchell CG, Nyquist SK, Chao MC, Maiello P, Myers AJ, Hopkins F, et al. CD8+ lymphocytes are critical for early control of tuberculosis in macaques. J Exp Med. 2023;220:e20230707.

Tang H, Wang Y, Chlewicki LK, Zhang Y, Guo J, Liang W, et al. Facilitating T-Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade. Cancer Cell. 2016;29:285–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park JA, Wang L, Cheung NV. Modulating tumor infiltrating myeloid cells to enhance bispecific antibody-driven T-cell infiltration and anti-tumor response. J Hematol Oncol. 2021;14:142.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shaler CR, Horvath C, Lai R, Xing Z. Understanding delayed T-cell priming, lung recruitment, and airway luminal T-cell responses in host defense against pulmonary tuberculosis. Clin Dev Immunol. 2012;2012:628293.

Article  PubMed  PubMed Central  Google Scholar 

Khader SA, Partida-Sanchez S, Bell G, Jelley-Gibbs DM, Swain S, Pearl JE, et al. Interleukin 12p40 is required for dendritic cell migration and T-cell priming after Mycobacterium tuberculosis infection. J Exp Med. 2006;203:1805–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clemmensen HS, Dube JY, McIntosh F, Rosenkrands I, Jungersen G, Aagaard C, et al. In vivo antigen expression regulates CD4 T-cell differentiation and vaccine efficacy against Mycobacterium tuberculosis infection. bioRxiv. 2021. https://www.biorxiv.org/content/10.1101/2021.02.02.429488v1.full.pdf.

Sadek MI, Sada E, Toossi Z, Schwander SK, Rich EA. Chemokines induced by infection of mononuclear phagocytes with mycobacteria and present in lung alveoli during active pulmonary tuberculosis. Am J Respir Cell Mol Biol. 1998;19:513–21.

Article  CAS  PubMed  Google Scholar 

Hao K, Zhou Q, Chen W, Jia W, Zheng J, Kang J, et al. Possible role of the ‘IDO-AhR axis’ in maternal-fetal tolerance. Cell Biol Int. 2013;37:105–8.

Article  CAS  PubMed  Google Scholar 

Shi J, Du T, Wang J, Tang C, Lei M, Yu W, et al. Aryl hydrocarbon receptor is a proviral host factor and a candidate pan-SARS-CoV-2 therapeutic target. Sci Adv. 2023;9:eadf0211.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma Z, Li Z, Mao Y, Ye J, Liu Z, Wang Y, et al. AhR diminishes the efficacy of chemotherapy by suppressing STING dependent type-I interferon in bladder cancer. Nat Commun. 2023;14:5415.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Venkateswaran N, Lafita-Navarro MC, Hao YH, Kilgore JA, Perez-Castro L, Braverman J, et al. MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer. Genes Dev. 2019;33:1236–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiao G, Zhang S, Zhang L, Liu S, Li G, Ou M, et al. Untargeted metabolomics analysis reveals Mycobacterium tuberculosis strain H37Rv specifically induces tryptophan metabolism in human macrophages. BMC Microbiol. 2022;22:249.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lerch S, Schefold JC, Spinetti T. The Role of Kynurenines Produced by Indolamine-2,3-Dioxygenase 1 in Sepsis. Pharmacology. 2022;107:359–67.

Article  CAS  PubMed  Google Scholar 

Liu Y, Liang X, Dong W, Fang Y, Lv J, Zhang T, et al. Tumor-Repopulating Cells Induce PD-1 Expression in CD8(+) T Cells by Transferring Kynurenine and AhR Activation. Cancer Cell. 2018;33:480–94.e7.

Article  CAS  PubMed  Google Scholar 

Campesato LF, Budhu S, Tchaicha J, Weng CH, Gigoux M, Cohen IJ, et al. Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine. Nat Commun. 2020;11:4011.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fong W, Li Q, Ji F, Liang W, Lau HCH, Kang X, et al. Lactobacillus gallinarum-derived metabolites boost anti-PD1 efficacy in colorectal cancer by inhibiting regulatory T cells through modulating IDO1/Kyn/AHR axis. Gut. 2023;72:2272–85.

Article  CAS  PubMed  Google Scholar 

Collins JM, Siddiqa A, Jones DP, Liu K, Kempker RR, Nizam A, et al. Tryptophan catabolism reflects disease activity in human tuberculosis. JCI Insight. 2020;5:e137131.

Gautam US, Foreman TW, Bucsan AN, Veatch AV, Alvarez X, Adekambi T, et al. In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis. Proc Natl Acad Sci USA. 2018;115:E62–e71.

Article  CAS  PubMed  Google Scholar 

Garrido-Martin EM, Mellows TWP, Clarke J, Ganesan AP, Wood O, Cazaly A, et al. M1(hot) tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer. J Immunother Cancer. 2020;8:e000778.

Wu D, Wang G, Wen S, Liu X, He Q. ARID5A stabilizes Indoleamine 2,3-dioxygenase expression and enhances CAR T-cell exhaustion in colorectal cancer. Transl Oncol. 2024;42:101900.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Herrera MT, Guzmán-Beltrán S, Bobadilla K, Santos-Mendoza T, Flores-Valdez MA, Gutiérrez-González LH, et al. Human Pulmonary Tuberculosis: Understanding the Immune Response in the Bronchoalveolar System. Biomolecules. 2022;12:1148.

Hiroi M, Ohmori Y. Constitutive nuclear factor kappaB activity is required to elicit interferon-gamma-induced expression of chemokine CXC ligand 9 (CXCL9) and CXCL10 in human tumor cell lines. Biochem J. 2003;376:393–402.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hiroi M, Ohmori Y. The transcriptional coactivator CREB-binding protein cooperates with STAT1 and NF-kappa B for synergistic transcriptional activation of the CXC ligand 9/monokine induced by interferon-gamma gene. J Biol Chem. 2003;278:651–60.

Article  CAS  PubMed  Google Scholar 

Clarke DL, Clifford RL, Jindarat S, Proud D, Pang L, Belvisi M, et al. TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein. J Biol Chem. 2010;285:29101–10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Au KK, Le Page C, Ren R, Meunier L, Clément I, Tyrishkin K, et al. STAT1-associated intratumoural T(H)1 immunity predicts chemotherapy resistance in high-grade serous ovarian cancer. J Pathol Clin Res. 2016;2:259–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sadik A, Somarribas Patterson LF, Öztürk S, Mohapatra SR, Panitz V, Secker PF, et al. IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression. Cell. 2020;182:1252–70.e34.

Article  CAS  PubMed  Google Scholar 

Goudot C, Coillard A, Villani AC, Gueguen P, Cros A, Sarkizova S, et al. Aryl Hydrocarbon Receptor Controls Monocyte Differentiation into Dendritic Cells versus Macrophages. Immunity. 2017;47:582–96.e6.

Article  CAS  PubMed  Google Scholar 

Mascanfroni ID, Takenaka MC, Yeste A, Patel B, Wu Y, Kenison JE, et al. Metabolic control of type 1 regulatory T-cell differentiation by AHR and HIF1-α. Nat Med. 2015;21:638–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang T, Song J, Gao J, Cheng J, Xie H, Zhang L, et al. Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR/STAT3/IL-6 signaling. Nat Commun. 2022;13:3489.

Article  CAS  PubMed  PubMed Central