Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71:209–49.

Article  PubMed  Google Scholar 

Cao W, Chen H-D, Yu Y-W, Li N, Chen W-Q. Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020. Chin Med J (Engl). 2021;134:783–91.

Article  PubMed  Google Scholar 

Sterner RC, Sterner RM. CAR-T cell therapy: current limitations and potential strategies. Blood Cancer J 2021 11:4. 2021;11:1–11.

Google Scholar 

Rui R, Zhou L, He S. Cancer immunotherapies: advances and bottlenecks. Front Immunol. 2023;14:1212476.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dougan M, Luoma AM, Dougan SK, Wucherpfennig KW. Understanding and treating the inflammatory adverse events of cancer immunotherapy. Cell. 2021;184:1575–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Imyanitov EN, Iyevleva AG, Levchenko EV. Molecular testing and targeted therapy for non-small cell lung cancer: Current status and perspectives. Crit Rev Oncol Hematol. 2021;157:103194.

Article  PubMed  Google Scholar 

Imyanitov E, Sokolenko A. Integrative Genomic Tests in Clinical Oncology. Int J Mol Sci. 2022;23:13129.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rafikova G, Gilyazova I, Enikeeva K, Pavlov V, Kzhyshkowska J. Prostate Cancer: Genetics, Epigenetics and the Need for Immunological Biomarkers. Int J Mol Sci. 2023;24:12797.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Larionova I, Tuguzbaeva G, Ponomaryova A, Stakheyeva M, Cherdyntseva N, Pavlov V, et al. Tumor-Associated Macrophages in Human Breast, Colorectal, Lung, Ovarian and Prostate Cancers. Front Oncol. 2020;10:566511.

Larionova I, Kazakova E, Patysheva M, Kzhyshkowska J. Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages. Cancers (Basel) 2020;12. https://doi.org/10.3390/cancers12061411.

Kloosterman DJ, Akkari L. Macrophages at the interface of the co-evolving cancer ecosystem. Cell. 2023;186:1627–51.

Article  CAS  PubMed  Google Scholar 

Peng Z-P, Jiang Z-Z, Guo H-F, Zhou M-M, Huang Y-F, Ning W-R, et al. Glycolytic activation of monocytes regulates the accumulation and function of neutrophils in human hepatocellular carcinoma. J Hepatol. 2020;73:906–17.

Article  CAS  PubMed  Google Scholar 

Patysheva M, Frolova A, Larionova I, Afanas’ev S, Tarasova A, Cherdyntseva N, et al. Monocyte programming by cancer therapy. Front Immunol. 2022;13:994319.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Larionova I, Patysheva M, Iamshchikov P, Kazakova E, Kazakova A, Rakina M, et al. PFKFB3 overexpression in monocytes of patients with colon but not rectal cancer programs pro-tumor macrophages and is indicative for higher risk of tumor relapse. Front Immunol. 2023;13:1080501.

Article  PubMed  PubMed Central  Google Scholar 

Patysheva M, Larionova I, Stakheyeva M, Grigoryeva E, Iamshchikov P, Tarabanovskaya N, et al. Effect of Early-Stage Human Breast Carcinoma on Monocyte Programming. Front Oncol 2022;11:800235.

Larionova I, Iamshchikov P, Kazakova A, Rakina M, Menyalo M, Enikeeva K, et al. Platinum-based chemotherapy promotes antigen presenting potential in monocytes of patients with high-grade serous ovarian carcinoma. Front Immunol. 2024;15:1414716.

Article  PubMed  PubMed Central  Google Scholar 

Zhu S, Yi M, Wu Y, Dong B, Wu K. Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies. Exp Hematol Oncol. 2021;10:60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, Li S, Liu F, Yang K. Role of CD68 in tumor immunity and prognosis prediction in pan-cancer. Sci Rep. 2022;12:7844.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Forssell J, Ӧberg A, Henriksson ML, Stenling R, Jung A, Palmqvist R. High Macrophage Infiltration along the Tumor Front Correlates with Improved Survival in Colon Cancer. Clin Cancer Res. 2007;13:1472–9.

Article  CAS  PubMed  Google Scholar 

Li J, Li L, Li Y, Long Y, Zhao Q, Ouyang Y, et al. Tumor-associated macrophage infiltration and prognosis in colorectal cancer: systematic review and meta-analysis. Int J Colorectal Dis. 2020;35:1203–10.

Article  PubMed  Google Scholar 

Gulubova M, Ananiev J, Yovchev Y, Julianov A, Karashmalakov A, Vlaykova T. The density of macrophages in colorectal cancer is inversely correlated to TGF-β1 expression and patients’ survival. J Mol Histol. 2013;44:679–92.

Article  CAS  PubMed  Google Scholar 

Zhou Q, Peng R-Q, Wu X-J, Xia Q, Hou J-H, Ding Y, et al. The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer. J Transl Med. 2010;8:13.

Article  PubMed  PubMed Central  Google Scholar 

Nakayama Y, Nagashima N, Minagawa N, Inoue Y, Katsuki T, Onitsuka K, et al. Relationships between tumor-associated macrophages and clinicopathological factors in patients with colorectal cancer. Anticancer Res. 2002;22:4291–6.

PubMed  Google Scholar 

Cavnar MJ, Turcotte S, Katz SC, Kuk D, Gönen M, Shia J, et al. Tumor-Associated Macrophage Infiltration in Colorectal Cancer Liver Metastases is Associated With Better Outcome. Ann Surg Oncol. 2017;24:1835–42.

Article  PubMed  PubMed Central  Google Scholar 

Majid U, Bergsland CH, Sveen A, Bruun J, Eilertsen IA, Bækkevold ES, et al. The prognostic effect of tumor-associated macrophages in stage I-III colorectal cancer depends on T cell infiltration. Cell Oncol. 2024;47:1267–76.

Article  CAS  Google Scholar 

Esbona K, Yi Y, Saha S, Yu M, Van Doorn RR, Conklin MW, et al. The Presence of Cyclooxygenase 2, Tumor-Associated Macrophages, and Collagen Alignment as Prognostic Markers for Invasive Breast Carcinoma Patients. Am J Pathol. 2018;188:559–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rakaee M, Busund L-TR, Jamaly S, Paulsen E-E, Richardsen E, Andersen S, et al. Prognostic Value of Macrophage Phenotypes in Resectable Non–Small Cell Lung Cancer Assessed by Multiplex Immunohistochemistry. Neoplasia. 2019;21:282–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kazakova E, Iamshchikov P, Larionova I, Kzhyshkowska J. Macrophage scavenger receptors: Tumor support and tumor inhibition. Front Oncol. 2023;12:1096897.

Heng Y, Zhu X, Lin H, jingyu M, Ding X, Tao L, et al. CD206+ tumor-associated macrophages interact with CD4+ tumor-infiltrating lymphocytes and predict adverse patient outcome in human laryngeal squamous cell carcinoma. J Transl Med. 2023;21:167.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang X, Yuwen T, Zhong Y, Li Z-G, Wang X-Y. A new method for predicting the prognosis of colorectal cancer patients through a combination of multiple tumor-associated macrophage markers at the invasive front. Heliyon. 2023;9:e13211.

Article  CAS  PubMed  PubMed Central  Google Scholar 

La Fleur L, Boura VF, Alexeyenko A, Berglund A, Pontén V, Mattsson JSM, et al. Expression of scavenger receptor MARCO defines a targetable tumor-associated macrophage subset in non-small cell lung cancer. Int J Cancer. 2018;143:1741–52.

Article  PubMed  Google Scholar 

Li Z, Maeda D, Yoshida M, Umakoshi M, Nanjo H, Shiraishi K, et al. The intratumoral distribution influences the prognostic impact of CD68- and CD204-positive macrophages in non-small cell lung cancer. Lung Cancer. 2018;123:127–35.

Article  PubMed  Google Scholar 

Riabov V, Yin S, Song B, Avdić A, Schledzewski K, Ovsiy I, et al. Stabilin-1 is expressed in human breast cancer and supports tumor growth in mammary adenocarcinoma mouse model. Oncotarget. 2016;7. https://doi.org/10.18632/oncotarget.8857.

Sumitomo R, Hirai T, Fujita M, Murakami H, Otake Y, Huang C. M2 tumor-associated macrophages promote tumor progression in non-small-cell lung cancer. Exp Ther Med. 2019;18:4490–8.

CAS  PubMed  PubMed Central  Google Scholar 

Wei C, Yang C, Wang S, Shi D, Zhang C, Lin X, et al. Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis. Mol Cancer. 2019;18:64.