Dysregulation in keratinocytes drives systemic lupus erythematosus onset

Tsokos GC. Autoimmunity and organ damage in systemic lupus erythematosus. Nat Immunol. 2020;21:605–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tian J, Zhang D, Yao X, Huang Y, Lu Q. Global epidemiology of systemic lupus erythematosus: a comprehensive systematic analysis and modeling study. Ann Rheum Dis. 2023;82:351–6.

Article  PubMed  Google Scholar 

Kobayashi T, Naik S, Nagao K. Choreographing Immunity in the Skin Epithelial Barrier. Immunity. 2019;50:552–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kabashima K, Honda T, Ginhoux F, Egawa G. The immunological anatomy of the skin. Nat Rev Immunol. 2019;19:19–30.

Article  CAS  PubMed  Google Scholar 

Pasparakis M, Haase I, Nestle FO. Mechanisms regulating skin immunity and inflammation. Nat Rev Immunol. 2014;14:289–301.

Article  CAS  PubMed  Google Scholar 

Tsujihana K, Tanegashima K, Santo Y, Yamada H, Akazawa S, Nakao R, et al. Circadian protection against bacterial skin infection by epidermal CXCL14-mediated innate immunity. Proc Natl Acad Sci USA. 2022;119:e2116027119.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stull C, Sprow G, Werth VP. Cutaneous Involvement in Systemic Lupus Erythematosus: A Review for the Rheumatologist. J Rheumatol. 2023;50:27–35.

Article  CAS  PubMed  Google Scholar 

Epstein JH, Tuffanelli D, Dubois EL. Light Sensitivity And Lupus Erythematosus. Arch Dermatol. 1965;91:483–5.

Article  CAS  PubMed  Google Scholar 

Sanders CJ, Van Weelden H, Kazzaz GA, Sigurdsson V, Toonstra J, Bruijnzeel-Koomen CA. Photosensitivity in patients with lupus erythematosus: a clinical and photobiological study of 100 patients using a prolonged phototest protocol. Br J Dermatol. 2003;149:131–7.

Article  CAS  PubMed  Google Scholar 

Hile GA, Coit P, Xu B, Victory AM, Gharaee-Kermani M, Estadt SN, et al. Regulation of Photosensitivity by the Hippo Pathway in Lupus Skin. Arthritis Rheumatol. 2023;75:1216–28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Der E, Suryawanshi H, Morozov P, Kustagi M, Goilav B, Ranabothu S, et al. Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways. Nat Immunol. 2019;20:915–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Psarras A, Alase A, Antanaviciute A, Carr IM, Md Yusof MY, Wittmann M, et al. Functionally impaired plasmacytoid dendritic cells and nonhaematopoietic sources of type I interferon characterize human autoimmunity. Nat Commun. 2020;11:6149.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sarkar MK, Hile GA, Tsoi LC, Xing X, Liu J, Liang Y, et al. Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa. Ann Rheum Dis. 2018;77:1653–64.

Article  CAS  PubMed  Google Scholar 

Tsoi LC, Hile GA, Berthier CC, Sarkar MK, Reed TJ, Liu J, et al. Hypersensitive IFN Responses in Lupus Keratinocytes Reveal Key Mechanistic Determinants in Cutaneous Lupus. J Immunol. 2019;202:2121–30.

Article  CAS  PubMed  Google Scholar 

Billi AC, Ma F, Plazyo O, Gharaee-Kermani M, Wasikowski R, Hile GA, et al. Nonlesional lupus skin contributes to inflammatory education of myeloid cells and primes for cutaneous inflammation. Sci Transl Med. 2022;14:eabn2263.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Luo S, Zhan Y, Wang J, Zhao R, Li Y, et al. Increased Expression of PPAR-γ Modulates Monocytes Into a M2-Like Phenotype in SLE Patients: An Implicative Protective Mechanism and Potential Therapeutic Strategy of Systemic Lupus Erythematosus. Front Immunol. 2020;11:579372.

Article  CAS  PubMed  Google Scholar 

Zhao W, Berthier CC, Lewis EE, McCune WJ, Kretzler M, Kaplan MJ. The peroxisome-proliferator activated receptor-γ agonist pioglitazone modulates aberrant T-cell responses in systemic lupus erythematosus. Clin Immunol. 2013;149:119–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hernandez-Quiles M, Broekema MF, Kalkhoven E. PPARgamma in Metabolism, Immunity, and Cancer: Unified and Diverse Mechanisms of Action. Front Endocrinol. 2021;12:624112.

Article  Google Scholar 

Aprahamian TR, Bonegio RG, Weitzner Z, Gharakhanian R, Rifkin IR. Peroxisome proliferator-activated receptor gamma agonists in the prevention and treatment of murine systemic lupus erythematosus. Immunology. 2014;142:363–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hasni S, Temesgen-Oyelakin Y, Davis M, Chu J, Poncio E, Naqi M, et al. Peroxisome proliferator activated receptor-γ agonist pioglitazone improves vascular and metabolic dysfunction in systemic lupus erythematosus. Ann Rheum Dis. 2022;81:1576–84.

Article  CAS  PubMed  Google Scholar 

Sahu RP, DaSilva SC, Rashid B, Martel KC, Jernigan D, Mehta SR, et al. Mice lacking epidermal PPARγ exhibit a marked augmentation in photocarcinogenesis associated with increased UVB-induced apoptosis, inflammation and barrier dysfunction. Int J Cancer. 2012;131:E1055–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hanley K, Jiang Y, Crumrine D, Bass NM, Appel R, Elias PM, et al. Activators of the nuclear hormone receptors PPARalpha and FXR accelerate the development of the fetal epidermal permeability barrier. J Clin Invest. 1997;100:705–12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chong HC, Tan MJ, Philippe V, Tan SH, Tan CK, Ku CW, et al. Regulation of epithelial–mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing. J Cell Biol. 2009;184:817–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Michalik L, Desvergne B, Tan NS, Basu-Modak S, Escher P, Rieusset J, et al. Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice. J Cell Biol. 2001;154:799–814.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nelson WG, Sun TT. The 50- and 58-kdalton keratin classes as molecular markers for stratified squamous epithelia: cell culture studies. J Cell Biol. 1983;97:244–51.

Article  CAS  PubMed  Google Scholar 

Cottle DL, Ursino G, Jones LK, Tham MS, Zylberberg AK, Smyth IM. Topical Aminosalicylic Acid Improves Keratinocyte Differentiation in an Inducible Mouse Model of Harlequin Ichthyosis. Cell Rep Med. 2020;1:100129.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang M, Cao P, Zhao Z, Wang Z, Jia C, Guo Y, et al. An Enhanced Expression Level of CXCR3 on Tfh-like Cells from Lupus Skin Lesions Rather Than Lupus Peripheral Blood. Clin Immunol. 2021;226:108717.

Article  CAS  PubMed  Google Scholar 

Hanaoka H, Nishimoto T, Okazaki Y, Takeuchi T, Kuwana M. A unique thymus-derived regulatory T-cell subset associated with systemic lupus erythematosus. Arthritis Res Ther. 2020;22:88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patel J, Vazquez T, Chin F, Keyes E, Yan D, Diaz D, et al. Multidimensional Immune Profiling of Cutaneous Lupus Erythematosus In Vivo Stratified by Patient Response to Antimalarials. Arthritis Rheumatol. 2022;74:1687–98.

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