PD-L1 positive platelets mediate resistance to immune checkpoint inhibitors in patients with colorectal cancer

Sung H, Ferlay J, Siegel R, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. Cancer J Clin. 2021;71(3):209–49 [PMID: 33538338 https://doi.org/10.3322/caac.21660].

Article  Google Scholar 

Yang L, Yang J, Kleppe A, Danielsen H, Kerr D. Personalizing adjuvant therapy for patients with colorectal cancer. Nat Reviews Clin Oncol. 2024;21(1):67–79 [PMID: 38001356 https://doi.org/10.1038/s41571-023-00834-2].

Article  CAS  Google Scholar 

Llosa N, Luber B, Siegel N, Awan A, Oke T, Zhu Q, Bartlett B, Aulakh L, Thompson E, Jaffee E, Durham J, Sears C, Le D, Diaz L, Pardoll D, Wang H, Housseau F, Anders R. Immunopathologic stratification of Colorectal Cancer for Checkpoint Blockade Immunotherapy. Cancer Immunol Res. 2019;7(10):1574–9 [PMID: 31439614 https://doi.org/10.1158/2326-6066.Cir-18-0927].

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin Z, Sinicrope F. Mismatch repair-deficient Colorectal Cancer: building on checkpoint blockade. J Clin Oncology: Official J Am Soc Clin Oncol. 2022;40(24):2735–50 [PMID: 35649217 https://doi.org/10.1200/jco.21.02691].

Article  CAS  Google Scholar 

Overman M, McDermott R, Leach J, Lonardi S, Lenz H, Morse M, Desai J, Hill A, Axelson M, Moss R, Goldberg M, Cao Z, Ledeine J, Maglinte G, Kopetz S, André T. Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study. Lancet Oncol. 2017;18(9):1182–91 [PMID: 28734759 https://doi.org/10.1016/s1470-2045(17)30422-9].

Article  CAS  PubMed  PubMed Central  Google Scholar 

Walsh L, Quail D. Decoding the tumor microenvironment with spatial technologies. Nat Immunol. 2023;24(12):1982–93 [PMID: 38012408 https://doi.org/10.1038/s41590-023-01678-9].

Article  CAS  PubMed  Google Scholar 

Zou W, Green D. Beggars banquet: metabolism in the tumor immune microenvironment and cancer therapy. Cell Metabol. 2023;35(7):1101–13 [PMID: 37390822 https://doi.org/10.1016/j.cmet.2023.06.003].

Article  CAS  Google Scholar 

Dudiki T, Veleeparambil M, Zhevlakova I, Biswas S, Klein E, Ford P, Podrez E, Byzova T. Mechanism of Tumor-Platelet Communications in Cancer. Circul Res. 2023;132(11):1447–61 [PMID: 37144446 https://doi.org/10.1161/circresaha.122.321861].

Article  CAS  Google Scholar 

Schmied L, Höglund P, Meinke S. Platelet-mediated Protection of Cancer cells from Immune Surveillance - possible implications for Cancer Immunotherapy. Frontiers in immunology 2021;12: 640578 [PMID: 33777033 https://doi.org/10.3389/fimmu.2021.640578

Duan X, Chen H, Zhou X, Liu P, Zhang X, Zhu Q, Zhong L, Zhang W, Zhang S, Zhang X, Chen Y, Zhou Y, Yang C, Feng Q, Zeng Y, Xu M, Xiang T. EBV Infection in epithelial malignancies induces resistance to Antitumor Natural Killer cells via F3-Mediated platelet aggregation. Cancer Res. 2022;82(6):1070–83 [PMID: 35064016 https://doi.org/10.1158/0008-5472.Can-21-2292].

Article  CAS  PubMed  Google Scholar 

Haemmerle M, Stone R, Menter D, Afshar-Kharghan V, Sood A. The platelet lifeline to Cancer: challenges and opportunities. Cancer Cell. 2018;33(6):965–83 [PMID: 29657130 https://doi.org/10.1016/j.ccell.2018.03.002].

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schlesinger M. Role of platelets and platelet receptors in cancer metastasis. J Hematol Oncol. 2018;11(1):125 [PMID: 30305116 https://doi.org/10.1186/s13045-018-0669-2].

Article  CAS  PubMed  PubMed Central  Google Scholar 

Menter D, Bresalier R. An aspirin a day: New Pharmacological developments and Cancer Chemoprevention. Annu Rev Pharmacol Toxicol. 2023;63:165–86 [PMID: 36202092 https://doi.org/10.1146/annurev-pharmtox-052020-023107]

Article  CAS  PubMed  Google Scholar 

Elwood P, Morgan G, Watkins J, Protty M, Mason M, Adams R, Dolwani S, Pickering J, Delon C, Longley M. Aspirin and cancer treatment: systematic reviews and meta-analyses of evidence: for and against. Br J Cancer. 2024;130(1):3–8 [PMID: 38030748 https://doi.org/10.1038/s41416-023-02506-5].

Article  PubMed  Google Scholar 

Elwood P, Protty M, Morgan G, Pickering J, Delon C, Watkins J. Aspirin and cancer: biological mechanisms and clinical outcomes. Open Biology. 2022;12(9):220124 [PMID: 36099932 https://doi.org/10.1098/rsob.220124].

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J, Xia Y, Sun B, Zheng N, Li Y, Pang X, Yang F, Zhao X, Ji Z, Yu H, Chen F, Zhang X, Zhao B, Jin J, Yang S, Cheng Z. Neutrophil extracellular traps induced by the hypoxic microenvironment in gastric cancer augment tumour growth. Cell Communication Signaling: CCS. 2023;21(1):86 [PMID: 37127629 https://doi.org/10.1186/s12964-023-01112-5].

Article  PubMed  PubMed Central  Google Scholar 

Nan H, Hutter C, Lin Y, Jacobs E, Ulrich C, White E, Baron J, Berndt S, Brenner H, Butterbach K, Caan B, Campbell P, Carlson C, Casey G, Chang-Claude J, Chanock S, Cotterchio M, Duggan D, Figueiredo J, Fuchs C, Giovannucci E, Gong J, Haile R, Harrison T, Hayes R, Hoffmeister M, Hopper J, Hudson T, Jenkins M, Jiao S, Lindor N, Lemire M, Le Marchand L, Newcomb P, Ogino S, Pflugeisen B, Potter J, Qu C, Rosse S, Rudolph A, Schoen R, Schumacher F, Seminara D, Slattery M, Thibodeau S, Thomas F, Thornquist M, Warnick G, Zanke B, Gauderman W, Peters U, Hsu L, Chan A. Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants. JAMA. 2015;313(11):1133–42 [PMID: 25781442 https://doi.org/10.1001/jama.2015.1815].

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rachidi S, Metelli A, Riesenberg B, Wu B, Nelson M, Wallace C, Paulos C, Rubinstein M, Garrett-Mayer E, Hennig M, Bearden D, Yang Y, Liu B, Li Z. Platelets subvert T cell immunity against cancer via GARP-TGFβ axis. Sci Immunol. 2017;2(11) [PMID: 28763790 https://doi.org/10.1126/sciimmunol.aai7911].

Bhatia H, Becker R, Leibundgut G, Patel M, Lacaze P, Tonkin A, Narula J, Tsimikas S. Lipoprotein(a), platelet function and cardiovascular disease. Nat Reviews Cardiol. 2023 [PMID: 37938756 https://doi.org/10.1038/s41569-023-00947-2].

Article  Google Scholar 

Bruce I, Kerry R. The effect of chloramphenicol and cycloheximide on platelet aggregation and protein synthesis. Biochem Pharmacol. 1987;36(11):1769–73. [PMID: 3579972 https://doi.org/10.1016/0006-2952(87)90236-x].

Article  CAS  PubMed  Google Scholar 

Rastin F, Javid H, Oryani M, Rezagholinejad N, Afshari A, Karimi-Shahri M. Immunotherapy for colorectal cancer: rational strategies and novel therapeutic progress. Int Immunopharmacol. 2023;126:111055 [PMID: 37992445 https://doi.org/10.1016/j.intimp.2023.111055].

Article  PubMed  Google Scholar 

Ganesh K, Stadler Z, Cercek A, Mendelsohn R, Shia J, Segal N, Diaz L. Immunotherapy in colorectal cancer: rationale, challenges and potential. Nat Reviews Gastroenterol Hepatol. 2019;16(6):361–75 [PMID: 30886395 https://doi.org/10.1038/s41575-019-0126-x].

Article  Google Scholar 

Hinterleitner C, Strähle J, Malenke E, Hinterleitner M, Henning M, Seehawer M, Bilich T, Heitmann J, Lutz M, Mattern S, Scheuermann S, Horger M, Maurer S, Walz J, Fend F, Handgretinger R, Seitz C, Weigelin B, Singer S, Salih H, Borst O, Kopp H, Zender L. Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer. Nat Commun. 2021;12(1):7005 [PMID: 34853305 https://doi.org/10.1038/s41467-021-27303-7].

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang Z, Wu G, Zhang X, Gao J, Meng C, Liu Y, Wei Q, Sun L, Wei P, Bai Z, Yao H, Zhang Z. Current progress and future perspectives of neoadjuvant anti-PD-1/PD-L1 therapy for colorectal cancer. Front Immunol. 2022;13:1001444 [PMID: 36159842 https://doi.org/10.3389/fimmu.2022.1001444].

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang L, Xue R, Pan C. Prognostic and clinicopathological value of PD-L1 in colorectal cancer: a systematic review and meta-analysis. OncoTargets Therapy. 2019;12:3671–82 [PMID: 31190869 https://doi.org/10.2147/ott.S190168].

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu T, Yang Y, Cheng C, Tu Y, Chen Y, Lee M, Tsai K. Phosphofructokinase platelet overexpression accelerated Colorectal Cancer Cell Growth and Motility. J Cancer. 2023;14(6):943–51 [PMID: 37151384 https://doi.org/10.7150/jca.82738].

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee A, Peterson E. Treatment of cancer-associated thrombosis. Blood. 2013;122(14):2310–7 [PMID: 23843493 https://doi.org/10.1182/blood-2013-04-460162].

Article  CAS  PubMed  Google Scholar 

Bick R. Cancer-associated thrombosis. The New England journal of medicine 2003; 349(2): 109–11 [PMID: 12853582 https://doi.org/10.1056/NEJMp030086].

留言 (0)

沒有登入
gif