Broadening horizons: molecular mechanisms and disease implications of endothelial-to-mesenchymal transition

Pober JS, Sessa WC. Evolving functions of endothelial cells in inflammation. Nat Rev Immunol. 2007;7:803–15.

Article  CAS  PubMed  Google Scholar 

Sturtzel C. Endothelial cells. Adv Exp Med Biol. 2017;1003:71–91.

Article  CAS  PubMed  Google Scholar 

Vestweber D. Relevance of endothelial junctions in leukocyte extravasation and vascular permeability. Ann N Y Acad Sci. 2012;1257:184–92.

Article  CAS  PubMed  Google Scholar 

Qian C, Yang C, Tang Y, Zheng W, Zhou Y, Zhang S, Song M, Cheng P, Wei Z, Zhong C, et al. Pharmacological manipulation of Ezh2 with salvianolic acid B results in tumor vascular normalization and synergizes with cisplatin and T cell-mediated immunotherapy. Pharmacol Res. 2022;182:106333.

Article  CAS  PubMed  Google Scholar 

von Gise A, Pu WT. Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease. Circ Res. 2012;110:1628–45.

Article  Google Scholar 

Ciszewski WM, Wawro ME, Sacewicz-Hofman I, Sobierajska K. Cytoskeleton reorganization in EndMT-The role in Cancer and Fibrotic diseases. Int J Mol Sci 2021, 22.

Sharma V, Dogra N, Saikia UN, Khullar M. Transcriptional regulation of endothelial-to-mesenchymal transition in cardiac fibrosis: role of myocardin-related transcription factor A and activating transcription factor 3. Can J Physiol Pharmacol. 2017;95:1263–70.

Article  CAS  PubMed  Google Scholar 

Carew RM, Wang B, Kantharidis P. The role of EMT in renal fibrosis. Cell Tissue Res. 2012;347:103–16.

Article  CAS  PubMed  Google Scholar 

Zeisberg EM, Tarnavski O, Zeisberg M, Dorfman AL, McMullen JR, Gustafsson E, Chandraker A, Yuan X, Pu WT, Roberts AB, et al. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med. 2007;13:952–61.

Article  CAS  PubMed  Google Scholar 

Hulshoff MS, Del Monte-Nieto G, Kovacic J, Krenning G. Non-coding RNA in endothelial-to-mesenchymal transition. Cardiovasc Res. 2019;115:1716–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu Z, Wang J, Pan T, Li X, Tao C, Wu Y, Wang X, Zhang Z, Liu Y, Zhang W, et al. The exosome-transmitted lncRNA LOC100132249 induces endothelial dysfunction in Diabetic Retinopathy. Diabetes. 2023;72:1307–19.

Article  PubMed  Google Scholar 

Frid MG, Kale VA, Stenmark KR. Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation - in vitro analysis. Circul Res. 2002;90:1189–96.

Article  CAS  Google Scholar 

Yoshimatsu Y, Watabe T. Emerging roles of inflammation-mediated endothelial-mesenchymal transition in health and disease. Inflamm Regen. 2022;42:9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ranchoux B, Antigny F, Rucker-Martin C, Hautefort A, Pechoux C, Bogaard HJ, Dorfmuller P, Remy S, Lecerf F, Plante S, et al. Endothelial-to-mesenchymal transition in pulmonary hypertension. Circulation. 2015;131:1006–18.

Article  CAS  PubMed  Google Scholar 

Ranchoux B, Harvey LD, Ayon RJ, Babicheva A, Bonnet S, Chan SY, Yuan JX, Perez VJ. Endothelial dysfunction in pulmonary arterial hypertension: an evolving landscape (2017 Grover Conference Series). Pulm Circ. 2018;8:2045893217752912.

Article  PubMed  Google Scholar 

Pinto MT, Covas DT, Kashima S, Rodrigues CO. Endothelial mesenchymal transition: comparative analysis of different induction methods. Biol Proced Online. 2016;18:10.

Article  PubMed  PubMed Central  Google Scholar 

Nickel J, Ten Dijke P, Mueller TD. TGF-beta family co-receptor function and signaling. Acta Biochim Biophys Sin (Shanghai). 2018;50:12–36.

Article  CAS  PubMed  Google Scholar 

Wu M, Wu S, Chen W, Li YP. The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease. Cell Res. 2024;34:101–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan J, Bao H, Fan YJ, Jiang ZL, Qi YX, Han Y. Platelet-derived microvesicles promote endothelial progenitor cell proliferation in intimal injury by delivering TGF-beta1. FEBS J. 2020;287:5196–217.

Article  CAS  PubMed  Google Scholar 

Bischoff J. Endothelial-to-mesenchymal transition. Circ Res. 2019;124:1163–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Song S, Zhang M, Yi Z, Zhang H, Shen T, Yu X, Zhang C, Zheng X, Yu L, Ma C, et al. The role of PDGF-B/TGF-beta1/neprilysin network in regulating endothelial-to-mesenchymal transition in pulmonary artery remodeling. Cell Signal. 2016;28:1489–501.

Article  CAS  PubMed  Google Scholar 

Medici D, Potenta S, Kalluri R. Transforming growth factor-beta2 promotes snail-mediated endothelial-mesenchymal transition through convergence of smad-dependent and smad-independent signalling. Biochem J. 2011;437:515–20.

Article  CAS  PubMed  Google Scholar 

Xu H, Huo R, Li H, Jiao Y, Weng J, Wang J, Yan Z, Zhang J, Zhao S, He Q, et al. KRAS mutation-induced EndMT of brain arteriovenous malformation is mediated through the TGF-beta/BMP-SMAD4 pathway. Stroke Vasc Neurol. 2023;8:197–206.

Article  PubMed  Google Scholar 

Perez L, Munoz-Durango N, Riedel CA, Echeverria C, Kalergis AM, Cabello-Verrugio C, Simon F. Endothelial-to-mesenchymal transition: cytokine-mediated pathways that determine endothelial fibrosis under inflammatory conditions. Cytokine Growth Factor Rev. 2017;33:41–54.

Article  CAS  PubMed  Google Scholar 

Rieder F, Kessler SP, West GA, Bhilocha S, de la Motte C, Sadler TM, Gopalan B, Stylianou E, Fiocchi C. Inflammation-induced endothelial-to-mesenchymal transition: a novel mechanism of intestinal fibrosis. Am J Pathol. 2011;179:2660–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sanchez-Duffhues G, Garcia de Vinuesa A, van de Pol V, Geerts ME, de Vries MR, Janson SG, van Dam H, Lindeman JH, Goumans MJ. Ten Dijke P: inflammation induces endothelial-to-mesenchymal transition and promotes vascular calcification through downregulation of BMPR2. J Pathol. 2019;247:333–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao T, Jiang Y, Li D, Sun X, Zhang Y, Qin L, Tellides G, Taylor HS, Huang Y. H19/TET1 axis promotes TGF-beta signaling linked to endothelial-to-mesenchymal transition. FASEB J. 2020;34:8625–40.

Article  CAS  PubMed  Google Scholar 

Adjuto-Saccone M, Soubeyran P, Garcia J, Audebert S, Camoin L, Rubis M, Roques J, Binetruy B, Iovanna JL, Tournaire R. TNF-alpha induces endothelial-mesenchymal transition promoting stromal development of pancreatic adenocarcinoma. Cell Death Dis. 2021;12:649.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yoshimatsu Y, Wakabayashi I, Kimuro S, Takahashi N, Takahashi K, Kobayashi M, Maishi N, Podyma-Inoue KA, Hida K, Miyazono K, Watabe T. TNF-alpha enhances TGF-beta-induced endothelial-to-mesenchymal transition via TGF-beta signal augmentation. Cancer Sci. 2020;111:2385–99.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yoshimatsu Y, Kimuro S, Pauty J, Takagaki K, Nomiyama S, Inagawa A, Maeda K, Podyma-Inoue KA, Kajiya K, Matsunaga YT, Watabe T. TGF-beta and TNF-alpha cooperatively induce mesenchymal transition of lymphatic endothelial cells via activation of activin signals. PLoS ONE. 2020;15:e0232356.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liguori TTA, Liguori GR, Moreira LFP, Harmsen MC. Adipose tissue-derived stromal cells’ conditioned medium modulates endothelial-mesenchymal transition induced by IL-1beta/TGF-beta2 but does not restore endothelial function. Cell Prolif. 2019;52:e12629.

留言 (0)

沒有登入
gif