Adams CM, Mitra R, Xiao Y, Michener P, Palazzo J, Chao A, et al. Targeted MDM2 degradation reveals a new vulnerability for p53-Inactivated triple-negative breast Cancer. Cancer Discov. 2023;13(5):1210–29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adema V, Palomo L, Walter W, Mallo M, Hutter S, La Framboise T, et al. Pathophysiologic and clinical implications of molecular profiles resultant from deletion 5q. EBioMedicine. 2022;80:104059.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bartlett A, O’Malley RC, Huang SC, Galli M, Nery JR, Gallavotti A, Ecker JR. Mapping genome-wide transcription-factor binding sites using DAP-seq. Nat Protoc. 2017;12(8):1659–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bergemann AD, Johnson EM. The HeLa pur factor binds single-stranded DNA at a specific element conserved in gene flanking regions and origins of DNA replication. Mol Cell Biol. 1992;12(3):1257–65.

CAS  PubMed  PubMed Central  Google Scholar 

Biancon G, Joshi P, Zimmer JT, Hunck T, Gao Y, Lessard MD, et al. Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies. Mol Cell. 2022;82(6):1107–22. e7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blue SM, Yee BA, Pratt GA, Mueller JR, Park SS, Shishkin AA, et al. Transcriptome-wide identification of RNA-binding protein binding sites using seCLIP-seq. Nat Protoc. 2022;17(5):1223–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bossemeyer D. The glycine-rich sequence of protein kinases: a multifunctional element. Trends Biochem Sci. 1994;19(5):201–5.

Article  CAS  PubMed  Google Scholar 

Chen NN, Khalili K. Transcriptional regulation of human JC Polyomavirus promoters by cellular proteins YB-1 and pur alpha in glial cells. J Virol. 1995;69(9):5843–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen F, Zhang W, Xu S, Zhang H, Chen L, Chen C, et al. Discovery and validation of PURA as a transcription target of 20(S)-protopanaxadiol: implications for the treatment of cognitive dysfunction. J Ginseng Res. 2023;47(5):662–71.

Article  PubMed  PubMed Central  Google Scholar 

Chepenik LG, Tretiakova AP, Krachmarov CP, Johnson EM, Khalili K. The single-stranded DNA binding protein, Pur-alpha, binds HIV-1 TAR RNA and activates HIV-1 transcription. Gene. 1998;210(1):37–44.

Article  CAS  PubMed  Google Scholar 

Dai C, Dehm SM, Sharifi N. Targeting the Androgen Signaling Axis in prostate Cancer. J Clin Oncol. 2023;41(26):4267–78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Danan C, Manickavel S, Hafner M. PAR-CLIP: a method for transcriptome-wide identification of RNA binding protein Interaction sites. Methods Mol Biol. 2016;1358:153–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Darbinian N, Gallia GL, King J, Del Valle L, Johnson EM, Khalili K. Growth inhibition of glioblastoma cells by human pur(alpha). J Cell Physiol. 2001;189(3):334–40.

Article  CAS  PubMed  Google Scholar 

Darbinian N, White MK, Khalili K. Regulation of the pur-alpha promoter by E2F-1. J Cell Biochem. 2006;99(4):1052–63.

Article  CAS  PubMed  Google Scholar 

Gallia GL, Darbinian N, Tretiakova A, Ansari SA, Rappaport J, Brady J, et al. Association of HIV-1 Tat with the cellular protein, puralpha, is mediated by RNA. Proc Natl Acad Sci U S A. 1999;96(20):11572–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gallia GL, Johnson EM, Khalili K. Puralpha: a multifunctional single-stranded DNA- and RNA-binding protein. Nucleic Acids Res. 2000;28(17):3197–205.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gallia GL, Darbinian N, Jaffe N, Khalili K. Single-stranded nucleic acid-binding protein, pur alpha, interacts with RNA homologous to 18S ribosomal RNA and inhibits translation in vitro. J Cell Biochem. 2001;83(3):355–63.

Article  CAS  PubMed  Google Scholar 

Gao J, Tian L, Sun Y, Li W, Zhao L, Sun Y, et al. PURalpha mediates epithelial-mesenchymal transition to promote esophageal squamous cell carcinoma progression by regulating Snail2. Cancer Lett. 2021;498:98–110.

Article  CAS  PubMed  Google Scholar 

Gupta M, Sueblinvong V, Raman J, Jeevanandam V, Gupta MP. Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure. J Biol Chem. 2003;278(45):44935–48.

Article  CAS  PubMed  Google Scholar 

Haas S, Thatikunta P, Steplewski A, Johnson EM, Khalili K, Amini S. A 39-kD DNA-binding protein from mouse brain stimulates transcription of myelin basic protein gene in oligodendrocytic cells. J Cell Biol. 1995;130(5):1171–9.

Article  CAS  PubMed  Google Scholar 

Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–74.

Article  CAS  PubMed  Google Scholar 

Hariharan S, Kelm RJ Jr., Strauch AR. The Puralpha/Purbeta single-strand DNA-binding proteins attenuate smooth-muscle actin gene transactivation in myofibroblasts. J Cell Physiol. 2014;229(9):1256–71.

Article  CAS  PubMed  Google Scholar 

Henley MJ, Koehler AN. Advances in targeting ‘undruggable’ transcription factors with small molecules. Nat Rev Drug Discov. 2021;20(9):669–88.

Article  CAS  PubMed  Google Scholar 

Inoue T, Leman ES, Yeater DB, Getzenberg RH. The potential role of purine-rich element binding protein (PUR) alpha as a novel treatment target for hormone-refractory prostate cancer. Prostate. 2008;68(10):1048–56.

Article  CAS  PubMed  Google Scholar 

Jeong DY, Lee KS, Choi JY, Chung MJ, Min YW, Kim HK, et al. Surgically resected esophageal squamous cell carcinoma: patient survival and clinicopathological prognostic factors. Sci Rep. 2020;10(1):5077.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ji J, Tsika GL, Rindt H, Schreiber KL, McCarthy JJ, Kelm RJ Jr., Tsika R. Puralpha and Purbeta collaborate with Sp3 to negatively regulate beta-myosin heavy chain gene expression during skeletal muscle inactivity. Mol Cell Biol. 2007;27(4):1531–43.

Article  CAS  PubMed  Google Scholar 

Johnson EM, Chen PL, Krachmarov CP, Barr SM, Kanovsky M, Ma ZW, Lee WH. Association of human pur alpha with the retinoblastoma protein, rb, regulates binding to the single-stranded DNA pur alpha recognition element. J Biol Chem. 1995;270(41):24352–60.

Article  CAS  PubMed  Google Scholar 

Johnson EM, Daniel DC, Gordon J. The pur protein family: genetic and structural features in development and disease. J Cell Physiol. 2013;228(5):930–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaya-Okur HS, Janssens DH, Henikoff JG, Ahmad K, Henikoff S. Efficient low-cost chromatin profiling with CUT&Tag. Nat Protoc. 2020;15(10):3264–83.

Article  CAS